Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to improve the health, nutrition, and growth performance. The present disclosure further relates to methods of modulating the microbial species present in the gastrointestinal tract of an animal. Such modulation includes, for example, modulating the level or function of microbial species.

Abstract: The invention is related to an inducible promoter for improved and regulated gene expression, useful in synthetic biology and metabolic engineering. In particular, the present invention relates to a nucleotide sequence comprising the regulatory regions of an erythritol- and erythrulose-inducible promoter in yeast and uses thereof in an expression system thus allowing an improved and regulated gene expression and production of gene product.

Abstract: A cowl for a turbomachine nozzle, the cowl having a plurality of repeated patterns disposed circumferentially at a trailing edge, each pattern being asymmetrical about a midplane of the pattern containing a longitudinal axis of the cowl, and each pattern having a first portion inclined radially towards the inside of the cowl and a second portion inclined radially towards the outside of the cowl.

Abstract: The present invention provides a burner (10) for a heater for combustion of a hydrocarbon liquid. The burner (10) comprises a combustion chamber having a combustion zone (17) for combusting the hydrocarbon liquid and at least one tank portion (13, 15) for containing an amount of the hydrocarbon liquid. The or each tank portion (13, 15) is positioned adjacent the combustion zone (17) and arranged to feed the hydrocarbon liquid into the combustion zone (17). The or each tank portion (13, 15) is at least in part filled with a filling material having a plurality of portions that pass through the interior of the or each tank portion (13, 15).

Abstract: A cowl for a turbomachine nozzle, the cowl having a plurality of repeated patterns disposed circumferentially at a trailing edge, each pattern being asymmetrical about a midplane of the pattern containing a longitudinal axis of the cowl, and each pattern having a first portion inclined radially towards the inside of the cowl and a second portion inclined radially towards the outside of the cowl.