Abstract: Provided are novel antibodies and antigen-binding fragments thereof that bind interleukin-18 receptor beta (IL-18R?), along with conjugates thereof, nucleic acids encoding the same, compositions comprising the same, and methods of producing and using the same, including in the treatment of various diseases and conditions, such as inflammatory bowel disease, and other immune-mediated diseases, autoimmune diseases, inflammatory diseases, cancers, and infectious diseases.

Abstract: Methods and systems for virtual on-set communication are provided. In one aspect, a method includes receiving, from a device of a first user, an input indicating that the first user is ready to start working on a project associated with the first user. The method also includes identifying, based on the project associated with the first user, a second set of users associated with the project. The method also includes generating a session identifier for a communication channel between the first user and one or more users of the second set of users. The method also includes generating messages for the communication channel, wherein the messages include a link to the communication channel. The method also includes transmitting the messages to the one or more users of the second set of users.