Patents by Inventor Stacey L. Halum

Stacey L. Halum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-DIMENSIONAL (3D) TISSUE-ENGINEERED MUSCLE FOR TISSUE RESTORATION
    Publication number: 20230365923
    Abstract: The present disclosure provides solid collagen constructs and tissue compositions, wherein a polymerizable collagen solution or suspension is extruded in the presence or absence of cells to formed an aligned architecture comprising solid collagen constructs such as those made with fibrillar collagen. Methods of using and of manufacturing solid collagen constructs and tissue compositions, where the component collagen is solid fibrillar collagen and cells are preferentially aligned, are also provided.
    Type: Application
    Filed: July 12, 2023
    Publication date: November 16, 2023
    Inventors: Sherry L. Voytik-Harbin, Stacey L. Halum, Sarah Brookes, Hongji Zhang
  • 3-dimensional (3D) tissue-engineered muscle for tissue restoration
    Patent number: 11739291
    Abstract: The present disclosure provides solid collagen constructs and tissue compositions, wherein a polymerizable collagen solution or suspension is extruded in the presence or absence of cells to formed an aligned architecture comprising solid collagen constructs such as those made with fibrillar collagen. Methods of using and of manufacturing solid collagen constructs and tissue compositions, where the component collagen is solid fibrillar collagen and cells are preferentially aligned, are also provided.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: August 29, 2023
    Assignee: Purdue Research Foundation
    Inventors: Sherry L. Voytik-Harbin, Stacey L. Halum, Sarah Brookes, Hongji Zhang
  • PRIMED MUSCLE PROGENITOR CELLS AND USES THEREOF
    Publication number: 20220110980
    Abstract: This invention relates to a method for repairing and reconstructing a damaged or non-functional muscle, in particular to a method and a tool kit using in vitro primed motor endplate-expressing muscle progenitor cells (MPCs) to promote innervation of the damaged or non-functional muscle using an agent without any genetic manipulation. This method is particularly useful for repairing or reconstructing damaged or non-functional head and neck muscles, and urinary detrusor bladder muscle.
    Type: Application
    Filed: December 16, 2021
    Publication date: April 14, 2022
    Applicant: Purdue Research Foundation
    Inventor: Stacey L Halum
  • Primed muscle progenitor cells and uses thereof
    Patent number: 11235005
    Abstract: This invention relates to a method for repairing and reconstructing a damaged or non-functional muscle, in particular to a method and a tool kit using in vitro primed motor endplate-expressing muscle progenitor cells (MPCs) to promote innervation of the damaged or non-functional muscle using an agent without any genetic manipulation. This method is particularly useful for repairing or reconstructing damaged or non-functional head and neck muscles, and urinary detrusor bladder muscle.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: February 1, 2022
    Assignee: Purdue Research Foundation
    Inventor: Stacey L. Halum
  • 3-DIMENSIONIAL (3D) TISSUE-ENGINEERED MUSCLE FOR TISSUE RESTORATION
    Publication number: 20200190466
    Abstract: The present disclosure provides solid collagen constructs and tissue compositions, wherein a polymerizable collagen solution or suspension is extruded in the presence or absence of cells to formed an aligned architecture comprising solid collagen constructs such as those made with fibrillar collagen. Methods of using and of manufacturing solid collagen constructs and tissue compositions, where the component collagen is solid fibrillar collagen and cells are preferentially aligned, are also provided.
    Type: Application
    Filed: April 25, 2018
    Publication date: June 18, 2020
    Applicant: Purdue Research Foundation
    Inventors: Sherry L. Voytik-Harbin, Stacey L. Halum, Sarah Brookes, Hongji Zhang
  • PRIMED MUSCLE PROGENITOR CELLS AND USES THEREOF
    Publication number: 20180311281
    Abstract: This invention relates to a method for repairing and reconstructing a damaged or non-functional muscle, in particular to a method and a tool kit using in vitro primed motor endplate-expressing muscle progenitor cells (MPCs) to promote innervation of the damaged or non-functional muscle using an agent without any genetic manipulation. This method is particularly useful for repairing or reconstructing damaged or non-functional head and neck muscles, and urinary detrusor bladder muscle.
    Type: Application
    Filed: April 27, 2018
    Publication date: November 1, 2018
    Applicant: Purdue Research Foundation
    Inventor: Stacey L. Halum
  • MUSCLE STEM CELL THERAPY FOR TREATMENT OF DYSPHAGIA
    Publication number: 20140120067
    Abstract: Described herein is a method for the treatment of dysphagia, comprising administering a therapeutically effective dose of an isolated muscle-derived stem cell population into a muscle involved in swallowing, such as tongue, pharynx, palate, and strap muscles.
    Type: Application
    Filed: October 31, 2013
    Publication date: May 1, 2014
    Applicant: Indiana University Research and Technology Corporation
    Inventor: Stacey L. Halum