Patents by Inventor Stacey M. Gifford

Stacey M. Gifford has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190331561
    Abstract: Techniques for phosphoprotein detection, quantification, and purification using a chip-based pillar array are provided. In one aspect, a method for purifying a protein sample includes: introducing a mixture including the protein sample and an antibody to a nanoDLD array having a plurality of pillars separated by a gap g, wherein the antibody and proteins in the protein sample form antibody-protein complexes having a size that is greater than a size threshold of the nanoDLD array created by the gap g which permits size-based separation of the antibody-protein complexes as the mixture flows through the nanoDLD array; and collecting a purified protein sample containing the antibody-protein complexes from the nanoDLD array. A lab-on-a-chip (LOC) device including the nanoDLD array is also provided.
    Type: Application
    Filed: July 9, 2019
    Publication date: October 31, 2019
    Inventors: Stacey M. Gifford, Gustavo A. Stolovitzky, Benjamin H. Wunsch
  • Patent number: 10386276
    Abstract: Techniques for phosphoprotein detection, quantification, and purification using a chip-based pillar array are provided. In one aspect, a method for purifying a protein sample includes: introducing a mixture including the protein sample and an antibody to a nanoDLD array having a plurality of pillars separated by a gap g, wherein the antibody and proteins in the protein sample form antibody-protein complexes having a size that is greater than a size threshold of the nanoDLD array created by the gap g which permits size-based separation of the antibody-protein complexes as the mixture flows through the nanoDLD array; and collecting a purified protein sample containing the antibody-protein complexes from the nanoDLD array. A lab-on-a-chip (LOC) device including the nanoDLD array is also provided.
    Type: Grant
    Filed: September 20, 2016
    Date of Patent: August 20, 2019
    Assignee: International Business Machines Corporation
    Inventors: Stacey M. Gifford, Gustavo A. Stolovitzky, Benjamin H. Wunsch
  • Publication number: 20190226953
    Abstract: Microscale and/or mesoscale condenser arrays that can facilitate microfluidic separation and/or purification of mesoscale and/or nanoscale particles and methods of operation are described herein. An apparatus comprises a condenser array comprising pillars arranged in a plurality of columns, wherein a pillar gap greater than or equal to about 0.5 micrometers is located between a first pillar of the pillars in a first column of the columns and a second pillar of the plurality of pillars in the first column, and wherein the first pillar is adjacent to the second pillar. The first ratio can be characterized by Dx/Dy is less than or equal to a first defined value, wherein Dx represents a first distance across the lattice in a first direction, wherein Dy represents a second distance across the lattice in a second direction, and wherein the first direction is orthogonal to the second direction.
    Type: Application
    Filed: January 19, 2018
    Publication date: July 25, 2019
    Inventors: Benjamin H. Wunsch, Joshua T. Smith, Sung-Cheol Kim, Stacey M. Gifford
  • Publication number: 20190224677
    Abstract: Microfluid chips that comprise one or more microscale and/or mesoscale condenser arrays, which can facilitate particle purification and/or fractionation, are described herein. In one embodiment, an apparatus can comprise a layer of a microfluidic chip. The layer can comprise an inlet that can receive fluid, an outlet that can output a purified version of the fluid, and a condenser array coupled between and in fluid communication with the inlet and the outlet. The condenser array can comprise a plurality of pillars arranged in a plurality of columns. Also, a pillar gap sized to facilitate a throughput rate of the fluid of greater than or equal to about 1.0 nanoliter per hour can be located between a first pillar of the plurality of pillars in a first column of the plurality of columns and a second pillar of the plurality of pillars in the first column.
    Type: Application
    Filed: January 19, 2018
    Publication date: July 25, 2019
    Inventors: Joshua T. Smith, Stacey M. Gifford, Sung-Cheol Kim, Benjamin H. Wunsch
  • Patent number: 10349653
    Abstract: The present disclosure relates to methods for forming an antimicrobial nanostructure and antimicrobial articles. The methods may include: providing a master template of a layout of the antimicrobial nanostructure on a silicon substrate, depositing a silicon nitride layer on a top surface of the silicon substrate, forming a patterned lithographic resist mask layer on a top surface of the silicon nitride layer, generating certain silicon pillars according to the patterned lithographic resist mask using a resist and reactive ion etching, forming certain lateral silicon nanospikes on the silicon pillars by performing metal assisted chemical etching (MacEtch), and removing the silicon nitride layer and bonding a top cover glass on the silicon pillars to form the antimicrobial nanostructure having lateral silicon nanospikes.
    Type: Grant
    Filed: October 17, 2018
    Date of Patent: July 16, 2019
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Stacey M. Gifford, Huan Hu, Pablo Meyer Rojas, Joshua T. Smith
  • Publication number: 20190200608
    Abstract: The method comprises contacting a silicon substrate with a silver salt and an acid for a time effective to produce spikes having a first end disposed on the silicon substrate and a second end extending away from the silicon substrate. The spikes have a second end diameter of about 10 nm to about 200 nm, a height of about 100 nm to 10 micrometers, and a density of about 10 to 100 per square microns. The nanostructures provide antimicrobial properties and can be transferred to the surface of various materials such as polymers.
    Type: Application
    Filed: March 11, 2019
    Publication date: July 4, 2019
    Inventors: STACEY M. GIFFORD, HUAN HU, PABLO M. ROJAS, GUSTAVO A. STOLOVITZKY
  • Publication number: 20190153516
    Abstract: A technique relates to separation of a mixture. A nano-deterministic lateral displacement (nanoDLD) array is configured to separate the mixture in a fluid. A feedback system is configured to control a velocity of the fluid through the nanoDLD array. The feedback system is configured to control the velocity of the fluid to separate one or more entities in the mixture.
    Type: Application
    Filed: January 22, 2019
    Publication date: May 23, 2019
    Inventors: Stacey M. Gifford, Joshua T. Smith, Benjamin H. Wunsch
  • Patent number: 10292384
    Abstract: The method comprises contacting a silicon substrate with a silver salt and an acid for a time effective to produce spikes having a first end disposed on the silicon substrate and a second end extending away from the silicon substrate. The spikes have a second end diameter of about 10 nm to about 200 nm, a height of about 100 nm to 10 micrometers, and a density of about 10 to 100 per square microns. The nanostructures provide antimicrobial properties and can be transferred to the surface of various materials such as polymers.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: May 21, 2019
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Stacey M. Gifford, Huan Hu, Pablo M. Rojas, Gustavo A. Stolovitzky
  • Publication number: 20190107539
    Abstract: Techniques for detection of virus-antibody nanocomplexes using a chip-based pillar array are provided. In one aspect, a method for virus detection is provided. The method includes the steps of: collecting a fluid sample from a virus-bearing source; contacting the fluid sample with an antibody that binds to viruses to form a sample-antibody mixture, wherein the antibody is labeled with a fluorescent tag; separating particles including any antibody-virus complexes, if present, from the sample-antibody mixture using an assay nanopillar array; and detecting the antibody-virus complexes, if present, in the particles from the separating step using fluorescence. A virus detection chip device and a chip-based immunoassay method are also provided.
    Type: Application
    Filed: December 10, 2018
    Publication date: April 11, 2019
    Inventors: Yann Astier, Stacey M. Gifford, Benjamin H. Wunsch
  • Patent number: 10251390
    Abstract: The present disclosure relates to methods for forming an antimicrobial nanostructure and antimicrobial articles. The methods may include: providing a master template of a layout of the antimicrobial nanostructure on a silicon substrate, depositing a silicon nitride layer on a top surface of the silicon substrate, forming a patterned lithographic resist mask layer on a top surface of the silicon nitride layer, generating certain silicon pillars according to the patterned lithographic resist mask using a resist and reactive ion etching, forming certain lateral silicon nanospikes on the silicon pillars by performing metal assisted chemical etching (MacEtch), and removing the silicon nitride layer and bonding a top cover glass on the silicon pillars to form the antimicrobial nanostructure having lateral silicon nanospikes.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: April 9, 2019
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Stacey M. Gifford, Huan Hu, Pablo Meyer Rojas, Joshua T. Smith
  • Patent number: 10253350
    Abstract: A technique relates to separation of a mixture. A nano-deterministic lateral displacement (nanoDLD) array is configured to separate the mixture in a fluid. A feedback system is configured to control a velocity of the fluid through the nanoDLD array. The feedback system is configured to control the velocity of the fluid to separate one or more entities in the mixture.
    Type: Grant
    Filed: September 20, 2016
    Date of Patent: April 9, 2019
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Stacey M. Gifford, Joshua T. Smith, Benjamin H. Wunsch
  • Publication number: 20190045777
    Abstract: The present disclosure relates to methods for forming an antimicrobial nanostructure and antimicrobial articles. The methods may include: providing a master template of a layout of the antimicrobial nanostructure on a silicon substrate, depositing a silicon nitride layer on a top surface of the silicon substrate, forming a patterned lithographic resist mask layer on a top surface of the silicon nitride layer, generating certain silicon pillars according to the patterned lithographic resist mask using a resist and reactive ion etching, forming certain lateral silicon nanospikes on the silicon pillars by performing metal assisted chemical etching (MacEtch), and removing the silicon nitride layer and bonding a top cover glass on the silicon pillars to form the antimicrobial nanostructure having lateral silicon nanospikes.
    Type: Application
    Filed: October 17, 2018
    Publication date: February 14, 2019
    Inventors: STACEY M. GIFFORD, HUAN HU, PABLO MEYER ROJAS, JOSHUA T. SMITH
  • Patent number: 10156568
    Abstract: Techniques for detection of virus-antibody nanocomplexes using a chip-based pillar array are provided. In one aspect, a method for virus detection is provided. The method includes the steps of: collecting a fluid sample from a virus-bearing source; contacting the fluid sample with an antibody that binds to viruses to form a sample-antibody mixture, wherein the antibody is labeled with a fluorescent tag; separating particles including any antibody-virus complexes, if present, from the sample-antibody mixture using an assay nanopillar array; and detecting the antibody-virus complexes, if present, in the particles from the separating step using fluorescence. A virus detection chip device and a chip-based immunoassay method are also provided.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: December 18, 2018
    Assignee: International Business Machines Corporation
    Inventors: Yann Astier, Stacey M. Gifford, Benjamin H. Wunsch
  • Publication number: 20180272048
    Abstract: Aspects include methods of fabricating antibacterial surfaces for medical implant devices including patterning a photoresist layer on a silicon substrate and etching the silicon to generate a plurality of nanopillars. Aspects also include removing the photoresist layer from the structure and coating the plurality of nanopillars with a biocompatible film. Aspects also include a system for preventing bacterial infection associated with medical implants including a thin silicon film including a plurality of nanopillars.
    Type: Application
    Filed: March 21, 2018
    Publication date: September 27, 2018
    Inventors: Stacey M. Gifford, Huan Hu, Emily R. Kinser, Roy R. Yu, Sufi Zafar
  • Publication number: 20180272046
    Abstract: Aspects include methods of fabricating antibacterial surfaces for medical implant devices including patterning a photoresist layer on a silicon substrate and etching the silicon to generate a plurality of nanopillars. Aspects also include removing the photoresist layer from the structure and coating the plurality of nanopillars with a biocompatible film. Aspects also include a system for preventing bacterial infection associated with medical implants including a thin silicon film including a plurality of nanopillars.
    Type: Application
    Filed: March 21, 2018
    Publication date: September 27, 2018
    Inventors: Stacey M. Gifford, Huan Hu, Emily R. Kinser, Roy R. Yu, Sufi Zafar
  • Publication number: 20180272047
    Abstract: Aspects include methods of fabricating antibacterial surfaces for medical implant devices including patterning a photoresist layer on a silicon substrate and etching the silicon to generate a plurality of nanopillars. Aspects also include removing the photoresist layer from the structure and coating the plurality of nanopillars with a biocompatible film. Aspects also include a system for preventing bacterial infection associated with medical implants including a thin silicon film including a plurality of nanopillars.
    Type: Application
    Filed: March 21, 2018
    Publication date: September 27, 2018
    Inventors: Stacey M. Gifford, Huan Hu, Emily R. Kinser, Roy R. Yu, Sufi Zafar
  • Publication number: 20180272045
    Abstract: Aspects include methods of fabricating antibacterial surfaces for medical implant devices including patterning a photoresist layer on a silicon substrate and etching the silicon to generate a plurality of nanopillars. Aspects also include removing the photoresist layer from the structure and coating the plurality of nanopillars with a biocompatible film. Aspects also include a system for preventing bacterial infection associated with medical implants including a thin silicon film including a plurality of nanopillars.
    Type: Application
    Filed: March 21, 2017
    Publication date: September 27, 2018
    Inventors: Stacey M. Gifford, Huan Hu, Emily R. Kinser, Roy R. Yu, Sufi Zafar
  • Publication number: 20180089739
    Abstract: Systems, methods, and computer-readable media are described for predicting consumer response to a stimulus based on olfactory characteristics of the stimulus. An intrinsic factor score associated with a product can be determined based on an intrinsic attribute of the stimulus, and optionally, further based on data indicative of historical consumer response to olfactory characteristics of the stimulus. A social factor score associated with a user can also be determined using available olfactory preference data associated with the user and/or data representative of one or more social signals indicative of a predicted response of the user to olfactory characteristics of the stimulus. A collaborative filtering technique can be employed to determine a recommendation score for the stimulus using the intrinsic factor score and the social factor score. The recommendation score can be compared to a threshold value to determine whether to recommend the stimulus to the user.
    Type: Application
    Filed: September 28, 2016
    Publication date: March 29, 2018
    Inventors: Guillermo Cecchi, Amit Dhurandhar, Stacey M. Gifford, Raquel Norel, Pablo Meyer Rojas, Kahn Rhrissorrakrai, Bo Zhang
  • Publication number: 20180080060
    Abstract: A technique relates to separation of a mixture. A nano-deterministic lateral displacement (nanoDLD) array is configured to separate the mixture in a fluid. A feedback system is configured to control a velocity of the fluid through the nanoDLD array. The feedback system is configured to control the velocity of the fluid to separate one or more entities in the mixture.
    Type: Application
    Filed: September 20, 2016
    Publication date: March 22, 2018
    Inventors: Stacey M. Gifford, Joshua T. Smith, Benjamin H. Wunsch
  • Publication number: 20180080857
    Abstract: Techniques for phosphoprotein detection, quantification, and purification using a chip-based pillar array are provided. In one aspect, a method for purifying a protein sample includes: introducing a mixture including the protein sample and an antibody to a nanoDLD array having a plurality of pillars separated by a gap g, wherein the antibody and proteins in the protein sample form antibody-protein complexes having a size that is greater than a size threshold of the nanoDLD array created by the gap g which permits size-based separation of the antibody-protein complexes as the mixture flows through the nanoDLD array; and collecting a purified protein sample containing the antibody-protein complexes from the nanoDLD array. A lab-on-a-chip (LOC) device including the nanoDLD array is also provided.
    Type: Application
    Filed: September 20, 2016
    Publication date: March 22, 2018
    Inventors: Stacey M. Gifford, Gustavo A. Stolovitzky, Benjamin H. Wunsch