Patents by Inventor Stacy E. Ferguson

Stacy E. Ferguson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Expression of Xenogenous (Human) Immunoglobulins in cloned, transgenic ungulates
    Publication number: 20110067122
    Abstract: The present invention relates to the production of a transgenic ungulate which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. This is effected by inactivation of the IgM heavy chain expression and, optionally, by inactivation of the Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of non-bovine antibodies, preferably human antibodies.
    Type: Application
    Filed: February 9, 2009
    Publication date: March 17, 2011
    Applicant: Kyowa Hakko Kirin Co., Ltd.
    Inventors: James M. Robl, Richard A. Goldsby, Stacy E. Ferguson, Yoshimi Kuroiwa, Kazuma Tomizuka, Isao Ishida, Barbara A. Osborne
  • Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates
    Patent number: 7491867
    Abstract: The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. This is effected by inactivation of the IgM heavy chain expression and, optionally, by inactivation of the Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of non-bovine antibodies, preferably human antibodies.
    Type: Grant
    Filed: December 1, 2005
    Date of Patent: February 17, 2009
    Assignee: Kyowa Hakko Kirin Co., Ltd.
    Inventors: James M. Robl, Richard A. Goldsby, Stacy E. Ferguson, Yoshimi Kuroiwa, Kazuma Tomizuka, Isao Ishida, Barbara A. Osborne
  • Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin
    Patent number: 7074983
    Abstract: The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. This is effected by inactivation of the IgM heavy chain expression and, optionally, by inactivation of the Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of non-bovine antibodies, preferably human antibodies.
    Type: Grant
    Filed: November 16, 2001
    Date of Patent: July 11, 2006
    Assignees: Kirin Beer Kabushiki Kaisha, Hematech, LLC
    Inventors: James M. Robl, Richard A. Goldsby, Stacy E. Ferguson, Yoshimi Kuroiwa, Kazuma Tomizuka, Isao Ishida, Barbara A. Osborne
  • Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates
    Publication number: 20030037347
    Abstract: The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and the expression of xenogenous antibodies, preferably human antibodies. This is effected by inactivation of the IgM heavy chain expression and, optionally, by inactivation of the Ig light chain expression, and by the further introduction of an artificial chromosome which results in the expression of non-bovine antibodies, preferably human antibodies.
    Type: Application
    Filed: November 16, 2001
    Publication date: February 20, 2003
    Inventors: James M. Robl, Richard A. Goldsby, Stacy E. Ferguson, Yoshimi Kuroiwa, Kazuma Tomizuka, Isao Ishida