Patents by Inventor Stacy W. Remiszewski

Stacy W. Remiszewski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Deacetylase inhibitors
    Patent number: 7067551
    Abstract: The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties.
    Type: Grant
    Filed: November 9, 2004
    Date of Patent: June 27, 2006
    Assignee: Novartis AG
    Inventors: Stacy W Remiszewski, Kenneth W Bair, Richard W Versace, Lawrence B Perez, Michael A Green, Lidia C Sambucetti, Sushil Sharma
  • N-substituted urea inhibitors of farnesyl-protein transferase
    Patent number: 6699872
    Abstract: Novel halo-N-substituted urea compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel halo-N-substituted urea compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.
    Type: Grant
    Filed: November 1, 2001
    Date of Patent: March 2, 2004
    Assignee: Schering Corporation
    Inventors: Stacy W. Remiszewski, Alan K. Mallams
  • Compounds for the inhibition of farnesyl protein transferase
    Patent number: 6576639
    Abstract: Novel compounds, such as: are disclosed. Also disclosed are methods for inhibiting the abnormal growth of cells, for inhibiting farnesyl protein transferase and for treating cancers using the novel compounds.
    Type: Grant
    Filed: March 8, 2000
    Date of Patent: June 10, 2003
    Assignee: Schering Corporation
    Inventors: Ronald J. Doll, Joseph M. Kelly, Alan K. Mallams, F. George Njoroge, Stacy W. Remiszewski, Arthur G. Taveras
  • Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
    Publication number: 20030055065
    Abstract: A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of Formula 1.
    Type: Application
    Filed: December 20, 2001
    Publication date: March 20, 2003
    Inventors: W. Robert Bishop, Ronald J. Doll, Alan K. Mallams, F. George Njoroge, Joanne M. Petrin, John J. Piwinski, Ronald L. Wolin, Arthur G. Taveras, Stacy W. Remiszewski
  • Deacetylase inhibitors
    Publication number: 20030018062
    Abstract: The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties.
    Type: Application
    Filed: August 31, 2001
    Publication date: January 23, 2003
    Inventors: Stacy W. Remiszewski, Kenneth W. Bair, Richard W. Versace, Lawrence B. Perez, Michael A. Green, Lidia C. Sambucetti, Sushil Sharma
  • Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
    Patent number: 6492381
    Abstract: A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a compound of Formula 1.0 Also disclosed are novel compounds of the formulas: and Also disclosed are processes for making 3-substituted compounds of the Formulas 1.1, 1.2 and 1.3. Further disclosed are novel compounds which are intermediates in the processes for making the 3-substituted compounds of Formulas 1.1, 1.2, and 1.3.
    Type: Grant
    Filed: May 16, 2000
    Date of Patent: December 10, 2002
    Assignee: Schering Corp.
    Inventors: W. Robert Bishop, Ronald J. Doll, Alan K. Mallams, F. George Njoroge, Joanne M. Petrin, John J. Piwinski, Ronald L. Wolin, Arthur G. Taveras, Stacy W. Remiszewski
  • Novel N-substituted urea inhibitors of farnesyl-protein transferase
    Publication number: 20020119981
    Abstract: Novel halo-N-substituted urea compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel halo-N-substituted urea compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.
    Type: Application
    Filed: November 1, 2001
    Publication date: August 29, 2002
    Inventors: Stacy W. Remiszewski, Alan K. Mallams
  • Compounds useful for inhibition of farnesyl protein transferase
    Patent number: 6410541
    Abstract: Novel compounds of the formula: are disclosed. In Formula 1.0 a represents N or NO, R1 and R3 are halo, R2 and R4 are independently H or halo provided that at least one is H, X is C, CH or N, and R represents a cycloalkyl or a heterocycloalkyl ring that is substitued. Also disclosed are methods of inhibiting farnesyl protein transferase and methods for treating tumor cells.
    Type: Grant
    Filed: January 24, 2001
    Date of Patent: June 25, 2002
    Assignee: Schering Corporation
    Inventors: Stacy W. Remiszewski, Ronald J. Doll, Carmen Alvarez, Tarik Lalwani
  • Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
    Publication number: 20020068742
    Abstract: A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of Formula 1.
    Type: Application
    Filed: April 9, 2001
    Publication date: June 6, 2002
    Inventors: W. Robert Bishop, Ronald J. Doll, Alan K. Mallams, F. George Njoroge, Joanne M. Petrin, John J. Piwinski, Ronald L. Wolin, Arthur G. Taveras, Stacy W. Remiszewski
  • Compounds useful for inhibition of farnesyl protein transferase
    Patent number: 6387905
    Abstract: Novel compounds of the formula: are disclosed. Compounds of Formula 1.0 are represented by the compounds of formulas: wherein R1, R3 and R4 are each independently selected from halo. Also disclosed are methods of inhibiting farnesyl protein transferase and the growth of abnormal cells, such as tumor cells.
    Type: Grant
    Filed: March 1, 2001
    Date of Patent: May 14, 2002
    Assignee: Schering Corporation
    Inventors: F George Njoroge, Arthur G. Taveras, Ronald J. Doll, Tarik Lalwani, Carmen Alvarez, Stacy W. Remiszewski
  • Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
    Patent number: 6365588
    Abstract: A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of Formula 1.0: to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. Novel compounds of the formulas 5.0, 5.1 and 5.2, wherein R is —C(R20)(R21)(R46), and 5.3, 5.3A and 5.3B, wherein R is —N(R25)(R48), are disclosed. Also disclosed are processes for making 3-substituted compounds of Formulas 5.0, 5.1, 5.2 and 5.3. Further disclosed are novel compounds which are intermediates in the process for making 3-substituted compounds of Formulas 5.0, 5.1, 5.2 and 5.3.
    Type: Grant
    Filed: July 9, 1999
    Date of Patent: April 2, 2002
    Assignee: Schering Corporation
    Inventors: Robert W. Bishop, Ronald J. Doll, Alan K. Mallams, F. George Njoroge, Joanne M. Petrin, John J. Piwinski, Ronald L. Wolin, Arthur G. Taveras, Stacy W. Remiszewski
  • N-substituted urea inhibitors of farnesyl-protein transferase
    Patent number: 6358968
    Abstract: Novel halo-N-substituted urea compounds and pharmaceutical compositions are disclosed which are inhibitors of the enzyme, farnesyl protein transferase. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering the novel halo-N-substituted urea compound to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammals such as a human.
    Type: Grant
    Filed: January 14, 2000
    Date of Patent: March 19, 2002
    Assignee: Schering Corporation
    Inventors: Stacy W. Remiszewski, Alan K. Mallams
  • Compounds useful for inhibition of farnesyl protein transferase
    Publication number: 20020019400
    Abstract: Novel compounds of the formula: 1
    Type: Application
    Filed: March 1, 2001
    Publication date: February 14, 2002
    Inventors: FGeorge Njoroje, Arthur G. Taveras, Ronald J. Doll, Tarik Lalwani, Carmen Alvarez, Stacy W. Remiszewski
  • Tricyclic carbamate compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
    Patent number: 6300338
    Abstract: A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a compound of Formula 1.0 Also disclosed are novel compounds of the formulas: Also disclosed are processes for making 3-substituted compounds of the Formulas 1.1, 1.2 and 1.3. Further disclosed are novel compounds which are intermediates in the processes for making the 3-substituted compounds of Formulas 1.1, 1.2, and 1.3.
    Type: Grant
    Filed: July 7, 1999
    Date of Patent: October 9, 2001
    Assignee: Schering Corporation
    Inventors: W. Robert Bishop, Ronald J. Doll, Alan K. Mallams, F. George Njoroge, Joanne M. Petrin, John J. Piwinski, Ronald L. Wolin, Arthur G. Taveras, Stacy W. Remiszewski
  • Tricyclic antitumor farnesyl protein transferase inhibitors
    Patent number: 6277854
    Abstract: The invention relates to compounds of the formula wherein R1, R2, R3, R4, R5, R6, R7, R8, Y, A, B, X, a, b, c, d, v, and w are as described herein. The compounds of formula (1.0) are useful for inhibiting tumor growth.
    Type: Grant
    Filed: July 13, 1999
    Date of Patent: August 21, 2001
    Assignee: Schering Corporation
    Inventors: F. George Njoroge, Ronald J. Doll, Stacy W. Remiszewski
  • Compounds useful for inhibition of farnesyl protein transferase
    Publication number: 20010007870
    Abstract: Novel compounds of the formula: 1
    Type: Application
    Filed: January 24, 2001
    Publication date: July 12, 2001
    Inventors: Stacy W. Remiszewski, Ronald J. Doll, Carmen Alvarez, Tarik Lalwani
  • Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
    Patent number: 6242458
    Abstract: A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of Formula 1.0: to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. Novel compounds of the formulas 5.1 and 5.2 are disclosed.
    Type: Grant
    Filed: September 21, 1999
    Date of Patent: June 5, 2001
    Assignee: Schering Corporation
    Inventors: W. Robert Bishop, Ronald J. Doll, Alan K. Mallams, F. George Njoroge, Joanne M. Petrin, John J. Piwinski, Ronald L. Wolin, Arthur G. Taveras, Stacy W. Remiszewski
  • Compounds useful for inhibition of farnesyl protein transferase
    Patent number: 6228856
    Abstract: Novel compounds of the formula: are disclosed. Compounds of Formula 1.0 are represented by the compounds of formulas: wherein R1, R3 and R4 are each independently selected from halo. Also disclosed are methods of inhibiting farnesyl protein transferase and the growth of abnormal cells, such as tumor cells.
    Type: Grant
    Filed: October 14, 1999
    Date of Patent: May 8, 2001
    Assignee: Schering Corporation
    Inventors: F George Njoroge, Arthur G. Taveras, Ronald J. Doll, Tarik Lalwani, Carmen Alvarez, Stacy W. Remiszewski
  • Tricyclic amides useful for inhibition of G-protein function and for treatment of proliferative disease
    Patent number: 6214828
    Abstract: Novel compounds, such as: are disclosed. Also disclosed are methods for inhibiting the abnormal growth of cells, for inhibiting farnesyl protein transferase and for treating cancers using the novel compounds.
    Type: Grant
    Filed: November 12, 1998
    Date of Patent: April 10, 2001
    Assignee: Schering Corporation
    Inventors: Ronald J. Doll, Joseph M. Kelly, Alan K. Mallams, F. George Njoroge, Stacy W. Remiszewski, Arthur G. Taveras
  • Compounds useful for inhibition of farnesyl protein transferase
    Patent number: 6211193
    Abstract: Novel compounds of the formula: are disclosed. In Formula 1.0 a represents N or NO, R1 and R3 are halo, R2 and R4 are independently H or halo provided that at least one is H, X is C, CH or N, and R represents a cycloalkyl or a heterocycloalkyl ring that is substitued. Also disclosed are methods of inhibiting farnesyl protein transferase and methods for treating tumor cells.
    Type: Grant
    Filed: June 15, 1998
    Date of Patent: April 3, 2001
    Assignee: Schering Corporation
    Inventors: Stacy W. Remiszewski, Ronald J. Doll, Carmen Alvarez, Tarik Lalwani