Patents by Inventor Staffan Folestad
Staffan Folestad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 8024154Abstract: A device and a method in processing, such as pharmaceutical processing, is provided. At least one signal is transmitted in a processing structure which is adapted to receive materials. The propagated signal is received and a parameter value thereof is compared with a reference value. The presence of materials or any other geometrical change in the processing structure is evaluated based on the comparison. The signal may be in the form of an electromagnetic wave, e.g. a microwave. Also, a use of a processing vessel, or a pipe connected to such a vessel, is provided.Type: GrantFiled: December 20, 2005Date of Patent: September 20, 2011Assignee: AstraZeneca ABInventors: Staffan Folestad, Lubomir Gradinarsky
-
Patent number: 7825668Abstract: A method related to a process for treating pharmaceutical contents in a pharmaceutical processing vessel is provided. The contents have a number of predefined parameters of variable values. According to the method electromagnetic radiation of various frequencies is transmitted into the vessel and its contents. Electromagnetic radiation which has interacted with the contents is received. Based on the received electromagnetic radiation, a respective value of a physical quantity related to the contents is determining for a plurality of said frequencies. A combination of values of said predefined parameters which would, for said plurality of frequencies, approximately result in the determined values of said physical quantity is determined.Type: GrantFiled: December 20, 2005Date of Patent: November 2, 2010Assignee: AstraZeneca ABInventors: Staffan Folestad, Lubomir Gradinarsky
-
Patent number: 7745789Abstract: The present invention relates to apparatuses for use in performing a quantitative analysis of a turbid pharmaceutical sample, e.g. a tablet, a capsule or a similar sample forming a pharmaceutical dose. A pharmaceutical, turbid sample (24, 57, 67) is irradiated with an excitation beam (20, 53, 64) of radiation, e.g. near infrared radiation. The intensity of emitted radiation (30) from the sample (24, 57, 67) is detected as function of both the wavelength of the emitted radiation and the photon propagation time through said sample (24, 57, 67). Optionally, the intensity of the emitted radiation (30) from the sample (24, 57, 67) is also detected in a spatially resolved manner.Type: GrantFiled: July 14, 2006Date of Patent: June 29, 2010Assignee: Astrazeneca ABInventors: Christoffer Abrahamsson, Stefan Andersson-Engels, Staffan Folestad, Jonas Johansson, Sune Svanberg
-
Publication number: 20080116056Abstract: A method related to a process for treating pharmaceutical contents in a pharmaceutical processing vessel is provided. The contents have a number of predefined parameters of variable values. According to the method electromagnetic radiation of various frequencies is transmitted into the vessel and its contents. Electromagnetic radiation which has interacted with the contents is received. Based on the received electromagnetic radiation, a respective value of a physical quantity related to the contents is determining for a plurality of said frequencies. A combination of values of said predefined parameters which would, for said plurality of frequencies, approximately result in the determined values of said physical quantity is determined.Type: ApplicationFiled: December 20, 2005Publication date: May 22, 2008Inventors: Staffan Folestad, Lubomir Gradinarsky
-
Patent number: 7329430Abstract: The present invention relates to a method for coating of a pharmaceutical product. The method comprises the step of producing discrete droplets (7) of controlled size, shape and composition with at least one micro dispenser (1) and distributing droplets (7) with controlled velocity, time of flight. Also, the method comprises the step of controlling the production frequency and modulation of the droplets (7). Further, the method comprises the step of controlling the flow rate, temperature and composition of the carrier gas and directing droplets (7) towards particles (10) subjected to coating. The present invention also relates to a device for coating of a pharmaceutical product. The device comprises a droplet producing unit (1) and a droplet-directing unit (8). The droplet producing unit (1) is a piezo-actuated micro dispenser (1) for producing discrete droplets (7) and controlling the size, shape and composition of said droplets (7).Type: GrantFiled: July 9, 2002Date of Patent: February 12, 2008Assignee: AstraZeneca ABInventors: Staffan Folestad, Ingela Niklasson Björn, Daniel Ström
-
Patent number: 7276700Abstract: The present invention relates to a method for analysing the amount of free gas within a pharmaceutical sample. According to the invention the method comprises the following steps: providing a sample before an irradiating source; irradiating the sample with at least one beam of electromagnetic radiation; detecting radiation emitted through the sample and generating signals corresponding to the amount of free gas in the sample, and correlating the generated signals to at least one solid state parameter of the sample.Type: GrantFiled: March 12, 2003Date of Patent: October 2, 2007Assignee: AstraZeneca ABInventors: Christoffer Abrahamson, Stefan Andersson-Engels, Staffan Folestad, Jonas Johansson, Mikael Sjöholm, Gabriel Somesfalean, Sune Svanberg
-
Patent number: 7219568Abstract: The present invention relates to a sample presentation apparatus for use in analyzing equipment for pharmaceutical products, for example solid dosage forms such as a tablet, a pellet or a capsule. The invention further relates to a method for presentation of samples to the analyzing equipment. Samples are sequentially fed through at least one predetermined analyzing position (6) wherein at least one measuring radiation beam irradiates the sample (14) when it is located in the analyzing position characterized in that there is at least one two-piece means (9, 39) for temporarily fixing each sample at said analyzing position (6), the two-piece means comprises a first and a second sample holding part arranged at the analyzing position in which the two-piece means is adapted to move between an open position wherein a sample is provided for analysis, and a closed fixing position wherein a sample is analyzed.Type: GrantFiled: January 26, 2001Date of Patent: May 22, 2007Assignee: AstraZeneca ABInventors: Staffan Folestad, Kurt Lundström, Göran Östling
-
Patent number: 7213474Abstract: An apparatus for use in sampling material on-line in a process system, comprising a sample collector (1) for receiving a sample of material, an elongate shaft (10) defining a passageway (14) carrying a measurement probe (11) for taking measurements from a colelcted sample, a pressurised fluid supply (31) connected to the passageway for delivering a pressurised fluid through the passageway to the sample collector for displacing the collected sample and a nozzle (33) provided at the distal end of the measurement probe (11) for distributing the pressurised fluid to the sample collector for displacing the collected sample from the sample collector (1).Type: GrantFiled: July 12, 2005Date of Patent: May 8, 2007Assignee: AstraZeneca ABInventors: Lennart Björk, Staffan Folestad, Mats Johansson, Anders Klevensparr, Ingela Niklasson Björn
-
Patent number: 7144147Abstract: A mixing apparatus for preparing from a plurality of materials, preferably powders, in particular components of a pharmaceutical composition, a mixture having a required homogeneity, comprising a non-rotating mixing vessel (7); at least one feeding mechanism for feeding said materials into said vessel (7); a stirring means (31) inside said vessel (7) for preparing said mixture; and at least one measuring device (23) for monitoring in-line at one or more locations in said vessel (7) the homogeneity of the mixture being prepared therein, wherein said at least one measuring device (23) comprises a unit for directing input radiation into said vessel (7), and at least one detector unit (45) for detecting output radiation formed by interaction of said input radiation with said materials in said vessel (7).Type: GrantFiled: June 18, 2003Date of Patent: December 5, 2006Assignee: Astrazeneca ABInventors: Staffan Folestad, Mats O. Johansson
-
Publication number: 20060243911Abstract: The present invention relates to apparatuses for use in performing a quantitative analysis of a turbid pharmaceutical sample, e.g. a tablet, a capsule or a similar sample forming a pharmaceutical dose. A pharmaceutical, turbid sample (24,57, 67) is irradiated with an excitation beam (20, 53, 64) of radiation, e.g. near infrared radiation. The intensity of emitted radiation (30) from the sample (24, 57, 67) is detected as function of both the wavelength of the emitted radiation and the photon propagation time through said sample (24, 57, 67). Optionally, the intensity of the emitted radiation (30) from the sample (24, 57, 67) is also detected in a spatially resolved manner.Type: ApplicationFiled: July 14, 2006Publication date: November 2, 2006Inventors: Christoffer Abrahamsson, Stefan Andersson-Engels, Staffan Folestad, Jonas Johansson, Sune Svanberg
-
Patent number: 7105823Abstract: The present invention relates to apparatuses for use in performing a quantitative analysis of a turbid pharmaceutical sample, e.g. a tablet, a capsule or a similar sample forming a pharmaceutical dose. A pharmaceutical, turbid sample (24, 57, 67) is irradiated with an excitation beam (20, 53, 64) of radiation, e.g. near infrared radiation. The intensity of emitted radiation (30) from the sample (24, 57, 67) is detected as function of both the wavelength of the emitted radiation and the photon propagation time through said sample (24, 57, 67). Optionally, the intensity of the emitted radiation (30) from the sample (24, 57, 67) is also detected in a spatially resolved manner.Type: GrantFiled: March 18, 2002Date of Patent: September 12, 2006Assignee: AstraZeneca ABInventors: Christoffer Abrahamsson, Stefan Andersson-Engels, Staffan Folestad, Jonas Johansson, Sune Svanberg
-
Publication number: 20050262928Abstract: An apparatus for use in sampling material on-line in a process system, comprising a sample collector (1) for receiving a sample of material, an elongate shaft (10) defining a passageway (14) carrying a measurement probe (11) for taking measurements from a colelcted sample, a pressurised fluid supply (31) connected to the passageway for delivering a pressurised fluid through the passageway to the sample collector for displacing the collected sample and a nozzle (33) provided at the distal end of the measurement probe (11) for distributing the pressurised fluid to the sample collector for displacing the collected sample from the sample collector (1).Type: ApplicationFiled: July 12, 2005Publication date: December 1, 2005Inventors: Lennart Bjork, Staffan Folestad, Mats Johansson, Anders Klevensparr, Ingela Bjorn
-
Patent number: 6946157Abstract: In a method of monitoring the formation of a coating on a single particle (P), an apparatus is used which comprises means (2,5,6,9) for arranging said particle (P) at a given spatial location, and a fluid supply unit (3) adapted to apply a coating fluid to the particle (P) such that the coating is formed. Further, the apparatus has a measurement unit (4) which is adapted to perform a spectrometric measurement on the coating during formation thereof, and to derive a measurement value of at least one principle parameter related to the coating. This, such principle parameters, for example the thickness, thickness growth rate and physical and/or chemical properties related to the quality of the coating, as well as heat, mass and momentum transfer, can be continuously and non-invasively monitored during the coating process on the single particle (P).Type: GrantFiled: January 8, 2001Date of Patent: September 20, 2005Assignee: AstraZeneca ABInventors: Staffan Folestad, Ingela Niklasson Björn, Anders Rasmuson, Daniel Ström
-
Publication number: 20050173637Abstract: The present invention relates to a method for analysing the amount of free gas within a pharmaceutical sample. According to the invention the method comprises the following steps: providing a sample before an irradiating source; irradiating the sample with at least one beam of electromagnetic radiation; detecting radiation emitted through the sample and generating signals corresponding to the amount of free gas in the sample, and correlating the generated signals to at least one solid state parameter of the sample.Type: ApplicationFiled: March 12, 2003Publication date: August 11, 2005Inventors: Christoffer Abrahamson, Stefan Andersson-Engels, Staffan Folestad, Jonas Johansson, Mikael Sjoholm, Gabriel Somesfalean, Sune Svanberg
-
Patent number: 6918310Abstract: An apparatus for use in sampling material on-line in a process system, comprising a sample collector (1) for receiving a sample of material, an elongate shaft (10) defining a passageway (14) carrying a measurement probe (11) for taking measurements from a collected sample, a pressurised fluid supply (31) connected to the passageway for delivering a pressurised fluid through the passageway to the sample collector for displacing the collected sample and a nozzle (33) provided at the distal end of the measurement probe (11) for distributing the pressurised fluid to the sample collector for displacing the collected sample from the sample collector (1).Type: GrantFiled: January 29, 2002Date of Patent: July 19, 2005Assignee: AstraZeneca ABInventors: Lennart Björk, Staffan Folestad, Mats Johansson, Anders Klevensparr, Ingela Niklasson Björn
-
Publication number: 20040247776Abstract: The present invention relates to a method for coating of a pharmaceutical product. The method comprises the step of producing discrete droplets (7) of controlled size, shape and composition with at least one micro dispenser (1) and distributing droplets (7) with controlled velocity, time of flight. Also, the method comprises the step of controlling the production frequency and modulation of the droplets (7). Further, the method comprises the step of controlling the flow rate, temperature and composition of the carrier gas and directing droplets (7) towards particles (10) subjected to coating. The present invention also relates to a device for coating of a pharmaceutical product. The device comprises a droplet producing unit (1) and a droplet-directing unit (8). The droplet producing unit (1) is a piezo-actuated micro dispenser (1) for producing discrete droplets (7) and controlling the size, shape and composition of said droplets (7).Type: ApplicationFiled: July 21, 2004Publication date: December 9, 2004Inventors: Staffan Folestad, Ingela Niklasson Bjorn, Daniel Strom
-
Patent number: 6794670Abstract: The present invention relates to a method and an apparatus for use in performing a quantitative analysis of a turbid pharmaceutical sample, e.g. a tablet, a capsule or a similar sample forming a pharmaceutical dose. A pharmaceutical, turbid sample (24) is irradiated with an excitation beam (20) of radiation, e.g. near infrared radiation. The intensity of emitted radiation (30) from the sample (24) is detected as a function of both the wavelength of the emitted radiation and the photon propagation time through said sample (24). Optionally, the intensity of the emitted radiation (30) from the sample (24) is also detected in a spatially resolved manner.Type: GrantFiled: November 3, 2000Date of Patent: September 21, 2004Assignee: AstraZeneca ABInventors: Staffan Folestad, Mats Josefson, Anders Sparén, Jonas Johansson
-
Publication number: 20040149914Abstract: The present invention relates to apparatuses for use in performing a quantitative analysis of a turbid pharmaceutical sample, e.g. a tablet, a capsule or a similar sample forming a pharmaceutical dose. A pharmaceutical, turbid sample (24, 57, 67) is irradiated with an excitation beam (20, 53, 64) of radiation, e.g. near infrared radiation. The intensity of emitted radiation (30) from the sample (24, 57, 67) is detected as function of both the wavelength of the emitted radiation and the photon propagation time through said sample (24, 57, 67). Optionally, the intensity of the emitted radiation (30) from the sample (24, 57, 67) is also detected in a spatially resolved manner.Type: ApplicationFiled: March 18, 2004Publication date: August 5, 2004Inventors: Christoffer Abrahamsson, Stefan Andersson-Engels, Staffan Folestad, Jonas Johansson, Sune Svanberg
-
Publication number: 20040057650Abstract: The present invention relates to a method and apparatus for monitoring characteristics of a pharmaceutical composition during preparation thereof by in the process vessel (1) of a fluidized bed apparatus, wherein a measuring device (11, 11′) performs a spectometric measurement on the pharmaceutical composition in a wetting zone (B) into which a processing fluid is injected. The method also comprises the generic use of an optical probe device in spectrometric measurements, the probe device being capable of transmitting a two-dimensional image of radiation emitted from a monitoring area in the process vessel (1).Type: ApplicationFiled: September 15, 2003Publication date: March 25, 2004Inventor: Staffan Folestad
-
Publication number: 20040050184Abstract: An apparatus for use in sampling material on-line in a process system, comprising a sample collector (1) for receiving a sample of material, an elongate shaft (10) defining a passageway (14) carrying a measurement probe (11) for taking measurements from a colelcted sample, a pressurised fluid supply (31) connected to the passageway for delivering a pressurised fluid through the passageway to the sample collector for displacing the collected sample and a nozzle (33) provided at the distal end of the measurement probe (11) for distributing the pressurised fluid to the sample collector for displacing the collected sample from the sample collector (1)Type: ApplicationFiled: July 8, 2003Publication date: March 18, 2004Inventors: Lennart Bjork, Staffan Folestad, Mats Johansson, Anders Klevensparr, Ingela Niklasson Bjorn