Abstract: The present invention relates to the field of breast cancer diagnosis and treatment. The present invention provides methods comprising a) analysing a biological sample obtained from a subject to determine the presence of target molecules representative of expression of at least two biomarkers selected from the group listed in Table 1, wherein the biological sample is a breast tissue sample or derivative thereof; and b) comparing the expression levels of the biomarkers determined in (a) with one or more reference values, wherein whether there is a difference in the expression of the biomarkers in the sample from the subject compared to the one or more reference values is indicative of a clinical indication. The invention further provides methods of treatment and kits and assays for use in the methods of the invention.

Abstract: The present invention relates to the diagnosis, prognosis, prediction and/or treatment of cancer, for example breast cancer, lung cancer or colon cancer. The present invention provides methods of diagnosing and/or prognosing cancer, predicting efficacy of treatment for cancer, assessing outcome of treatment for cancer, assessing likelihood of metastasis and/or assessing recurrence of cancer, the methods comprising a) analyzing a biological sample obtained from a subject to determine the presence of one or more target molecules representative of expression of SIGLEC1 and/or CCL8; and b) comparing the expression level of SIGLEC1 and/or CCL8 determined in (a) with one or more reference values, wherein whether there is a difference in the expression of SIGLEC1 and/or CCL8 in the sample from the subject or not compared to the one or more reference values is indicative of a clinical indication.