Patents by Inventor Stan Lam
Stan Lam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10527170Abstract: An osmotic delivery system is disclosed for delivering an active agent formulation to a fluid environment. The osmotic delivery system typically comprises a reservoir having a lumen that contains the active agent formulation and an osmotic agent formulation and a piston assembly positioned in the lumen to isolate the active agent formulation from the osmotic agent formulation. The piston assembly typically comprises a body constructed and arranged for positioning in the lumen. The body is typically made of a polymeric material that is, for example, resistant to leaching in an organic solvent. In one embodiment, the body is a columnar body having a rim at a distal end thereof for engaging and sealing against a wall of the reservoir and the piston assembly further comprises a spring retained at the distal end of the columnar body for biasing the rim of the columnar body against the wall of the reservoir.Type: GrantFiled: June 27, 2014Date of Patent: January 7, 2020Assignee: INTARCIA THERAPEUTICS, INC.Inventors: Thomas R. Alessi, Michael A. DesJardin, Stan Lam, Scott D. Lautenbach, Pauline C. Zamora
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Patent number: 10098771Abstract: A sheath is placed over a crimped scaffold to reduce recoil of the crimped polymer scaffold and maintain scaffold-balloon engagement relied on to hold the scaffold to the balloon when the scaffold is being delivered to a target in a body. The sheath has an opening spanning the length of the sheath. The opening spans an arc length of about 90 degrees with respect to the circumference of the scaffold or balloon. The sheath may be removed from the scaffold by pinching the sheath between a thumb and forefinger, or bending or peeling back the sheath from the edges of the opening using fingertips.Type: GrantFiled: September 25, 2013Date of Patent: October 16, 2018Assignee: ABBOTT CARDIOVASCULAR SYSTEMS INC.Inventors: Stan Lam, Erika Danielle Anderson-Bolden
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Publication number: 20170348392Abstract: A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.Type: ApplicationFiled: June 19, 2017Publication date: December 7, 2017Inventors: Catherine M. ROHLOFF, Guohua CHEN, Andrew S. LUK, Rupal A. Ayer, Paul R. Houston, Michael A. Desjardin, Pauline Zamora, Stan Lam
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Publication number: 20170056476Abstract: A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pryyolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.Type: ApplicationFiled: November 1, 2016Publication date: March 2, 2017Inventors: Catherine M. ROHLOFF, Guohua CHEN, Andrew S. LUK, Rupal A. Ayer, Paul R. Houston, Michael A. Desjardin, Pauline Zamora, Stan Lam
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Patent number: 9526763Abstract: A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.Type: GrantFiled: June 24, 2015Date of Patent: December 27, 2016Assignee: Intarcia Therapeutics Inc.Inventors: Catherine M. Rohloff, Guohua Chen, Andrew S. Luk, Rupal A. Ayer, Paul R. Houston, Michael A. Desjardin, Pauline Zamora, Stan Lam
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Patent number: 9510964Abstract: A stent crimping tool insert comprises a core body configured for insertion into and removal from within a crimping chamber of a stent crimping tool. The core body has a core surface configured to withstand a compressive force without a reduction in diameter of the core surface.Type: GrantFiled: August 5, 2015Date of Patent: December 6, 2016Assignee: ABBOTT CARDIOVASCULAR SYSTEMS INC.Inventors: Karen J. Wang, Edward P. Garcia, Manish Gada, Marc Schraner, Michael Green, Stan Lam
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Publication number: 20150359650Abstract: A stent crimping tool insert comprises a core body configured for insertion into and removal from within a crimping chamber of a stent crimping tool. The core body has a core surface configured to withstand a compressive force without a reduction in diameter of the core surface.Type: ApplicationFiled: August 5, 2015Publication date: December 17, 2015Inventors: Karen J. Wang, Edward P. Garcia, Manish Gada, Marc Schraner, Michael Green, Stan Lam
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Publication number: 20150290291Abstract: A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, other of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.Type: ApplicationFiled: June 24, 2015Publication date: October 15, 2015Inventors: Catherine M. ROHLOFF, Guohua CHEN, Andrew S. LUK, Rupal A. Ayer, Paul R. Houston, Michael A. Desjardin, Pauline Zamora, Stan Lam
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Patent number: 9125763Abstract: A stent crimping tool insert comprises a core body configured for insertion into and removal from within a crimping chamber of a stent crimping tool. The core body has a core surface configured to withstand a compressive force without a reduction in diameter of the core surface.Type: GrantFiled: March 15, 2013Date of Patent: September 8, 2015Assignee: Abbott Cardiovascular Systems Inc.Inventors: Karen J. Wang, Edward P. Garcia, Manish Gada, Marc Schraner, Michael Green, Stan Lam
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Patent number: 9095553Abstract: A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.Type: GrantFiled: October 9, 2012Date of Patent: August 4, 2015Assignee: Intarcia Therapeutics Inc.Inventors: Catherine M. Rohloff, Guohua Chen, Andrew S. Luk, Rupal A. Ayer, Paul R. Houston, Michael A. Desjardin, Pauline Zamora, Stan Lam
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Publication number: 20150157751Abstract: Sterilization of medical devices can be performed by stacking packages containing the medical devices. The packages are arranged in a partially-overlapping orientation which is at an oblique angle to the direction of irradiation. The partially-overlapping orientation and oblique angle are predetermined for high sterilization throughput and tight control of irradiation. Instead arranging the packages directly on a sterilization platform at a sterilization facility, the packages can be stacked in the partially-overlapping orientation into a transport container at a location remote from the sterilization facility. The transport container maintains the orientation of the packages. Thereafter, the transport container is placed on the sterilization platform, which results in greater uniformity in radiation exposure while maintaining a high level of sterilization throughput.Type: ApplicationFiled: February 18, 2015Publication date: June 11, 2015Inventors: Stan Lam, James Wise
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Publication number: 20150088240Abstract: A sheath is placed over a crimped scaffold to reduce recoil of the crimped polymer scaffold and maintain scaffold-balloon engagement relied on to hold the scaffold to the balloon when the scaffold is being delivered to a target in a body. The sheath has an opening spanning the length of the sheath. The opening spans an arc length of about 90 degrees with respect to the circumference of the scaffold or balloon. The sheath may be removed from the scaffold by pinching the sheath between a thumb and forefinger, or bending or peeling back the sheath from the edges of the opening using fingertips.Type: ApplicationFiled: September 25, 2013Publication date: March 26, 2015Applicant: Abbott Cardiovascular Systems Inc.Inventors: Stan Lam, Erika Danielle Anderson-Bolden
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Patent number: 8986608Abstract: Sterilization of medical devices can be performed by stacking packages containing the medical devices. The packages are arranged in a partially-overlapping orientation which is at an oblique angle to the direction of irradiation. The partially-overlapping orientation and oblique angle are predetermined for high sterilization throughput and tight control of irradiation. Instead arranging the packages directly on a sterilization platform at a sterilization facility, the packages can be stacked in the partially-overlapping orientation into a transport box at a location remote from the sterilization facility. The transport box maintains the orientation of the packages. Thereafter, the transport container is placed on the sterilization platform, which results in greater uniformity in radiation exposure while maintaining a high level of sterilization throughput.Type: GrantFiled: May 17, 2011Date of Patent: March 24, 2015Assignee: Abbott Cardiovascular Systems Inc.Inventors: Stan Lam, James Wise
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Publication number: 20140378900Abstract: An osmotic delivery system is disclosed for delivering an active agent formulation to a fluid environment. The osmotic delivery system typically comprises a reservoir having a lumen that contains the active agent formulation and an osmotic agent formulation and a piston assembly positioned in the lumen to isolate the active agent formulation from the osmotic agent formulation. The piston assembly typically comprises a body constructed and arranged for positioning in the lumen. The body is typically made of a polymeric material that is, for example, resistant to leaching in an organic solvent. In one embodiment, the body is a columnar body having a rim at a distal end thereof for engaging and sealing against a wall of the reservoir and the piston assembly further comprises a spring retained at the distal end of the columnar body for biasing the rim of the columnar body against the wall of the reservoir.Type: ApplicationFiled: June 27, 2014Publication date: December 25, 2014Inventors: Thomas R. Alessi, Michael A. DesJardin, Stan Lam, Scott D. Lautenbach, Pauline C. Zamora
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Publication number: 20140260502Abstract: A stent crimping tool insert comprises a core body configured for insertion into and removal from within a crimping chamber of a stent crimping tool. The core body has a core surface configured to withstand a compressive force without a reduction in diameter of the core surface.Type: ApplicationFiled: March 15, 2013Publication date: September 18, 2014Inventors: Karen J. Wang, Edward P. Garcia, Manish Gada, Marc Schraner, Michael Green, Stan Lam
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Patent number: 8801700Abstract: An osmotic delivery system is disclosed for delivering an active agent formulation to a fluid environment. The osmotic delivery system typically comprises a reservoir having a lumen that contains the active agent formulation and an osmotic agent formulation and a piston assembly positioned in the lumen to isolate the active agent formulation from the osmotic agent formulation. The piston assembly typically comprises a body constructed and arranged for positioning in the lumen. The body is typically made of a polymeric material that is, for example, resistant to leaching in an organic solvent. In one embodiment, the body is a columnar body having a rim at a distal end thereof for engaging and sealing against a wall of the reservoir and the piston assembly further comprises a spring retained at the distal end of the columnar body for biasing the rim of the columnar body against the wall of the reservoir.Type: GrantFiled: January 19, 2011Date of Patent: August 12, 2014Assignee: Intarcia Therapeutics, Inc.Inventors: Thomas R. Alessi, Michael A. DesJardin, Stan Lam, Scott D. Lautenbach, Pauline C. Zamora
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Patent number: 8460694Abstract: A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.Type: GrantFiled: October 8, 2012Date of Patent: June 11, 2013Assignee: Intarcia Therapeutics, Inc.Inventors: Catherine M. Rohloff, Guohua Chen, Andrew S. Luk, Rupal A. Ayer, Paul R. Houston, Michael A. Desjardin, Pauline Zamora, Stan Lam
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Patent number: 8440226Abstract: A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.Type: GrantFiled: June 18, 2012Date of Patent: May 14, 2013Assignee: Intarcia Therapeutics, Inc.Inventors: Catherine M. Rohloff, Guohua Chen, Andrew S. Luk, Rupal A. Ayer, Paul R. Houston, Michael A. Desjardin, Pauline Zamora, Stan Lam
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Publication number: 20130034210Abstract: A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.Type: ApplicationFiled: October 9, 2012Publication date: February 7, 2013Applicant: Intarcia Therapeutics, Inc.Inventors: Catherine M. Rohloff, Guohua Chen, Andrew S. Luk, Rupal A. Ayer, Paul R. Houston, Michael A. Desjardin, Pauline Zamora, Stan Lam
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Publication number: 20130035670Abstract: A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.Type: ApplicationFiled: October 8, 2012Publication date: February 7, 2013Applicant: INTARCIA THERAPEUTICS, INC.Inventors: Catherine M. Rohloff, Guohua Chen, Andrew S. Luk, Rupal A. Ayer, Paul R. Houston, Michael A. Desjardin, Pauline Zamora, Stan Lam