Patents by Inventor Stanislas Blein

Stanislas Blein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-TRKA ANTIBODIES WITH ENHANCED INHIBITORY PROPERTIES AND DERIVATIVES THEREOF
    Publication number: 20130344064
    Abstract: The present invention relates to antibodies directed against TrkA receptor and their uses, including humanized anti-TrkA antibodies. More specifically, the present invention relates to humanized anti-TrkA antibodies with enhanced inhibitory properties comprising a heavy chain variable region, a light chain, variable region, a human light chain constant region and a variant human IgG4 heavy chain constant region which exhibit altered exchange properties.
    Type: Application
    Filed: June 7, 2013
    Publication date: December 26, 2013
    Inventors: STANISLAS BLEIN, ROMAIN OLLIER, DARKO SKEGRO
  • Antibodies that bind to OX40 and their uses
    Publication number: 20130183315
    Abstract: The present invention relates to antagonist antibodies or fragments thereof that bind to human OX40. More specifically, the present invention relates to an antagonist antibody or fragment thereof that binds to human OX40 comprising a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO: 1, and/or a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO: 2, and/or a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO: 3; and/or comprising a light chain CDR1 comprising the amino acid sequence of SEQ ID NO: 4, and/or a light chain CDR2 comprising the amino acid sequence of SEQ ID NO: 5 and/or a light chain CDR3 comprising the amino acid sequence of SEQ ID NO: 6.
    Type: Application
    Filed: July 10, 2012
    Publication date: July 18, 2013
    Applicant: Glenmark Pharmaceuticals S.A.
    Inventors: Antoine Attinger, Stanislas Blein, Jonathan Albert Back, Rami Lissilaa, Samuel Hou
  • Hetero-Dimeric Immunoglobulins
    Publication number: 20130178605
    Abstract: The present invention relates to engineered hetero-dimeric immunoglobulins or fragments thereof and methods of making the same.
    Type: Application
    Filed: March 23, 2012
    Publication date: July 11, 2013
    Inventors: Stanislas Blein, Darko Skegro, Chaux Skegro, Paul Wassman
  • ANTI-ALPHA2 INTEGRIN ANTIBODIES AND THEIR USES
    Publication number: 20130052191
    Abstract: The invention relates to antibodies directed to ?2?1 integrin and their uses, including humanized anti-alpha 2 (?2) integrin antibodies and methods of treatment with anti-?2integrin antibodies. More specifically the present invention relates to humanized anti-?2 integrin antibodies comprising a heavy chain variable region, a light chain variable region, a human light chain constant region and a variant human IgG1 heavy chain constant region which exhibit altered effector function.
    Type: Application
    Filed: February 22, 2011
    Publication date: February 28, 2013
    Applicant: SANOFI
    Inventors: Stanislas Blein, Samuel Hou, Darko Skegro
  • ANTAGONISTS AGAINST TNFR1 AND METHODS OF USE THEREFOR
    Publication number: 20130022605
    Abstract: The invention provides methods for treating inflammatory diseases (e.g., chronic inflammatory diseases) comprising administering an antagonist of Tumor Necrosis Factor Receptor 1. The invention also provides ligands that contain an immunoglobulin single variable domain (domain antibody, dAb) monomer that binds Tumor Necrosis Factor Receptor 1, and methods of using the ligands. Also provided are nucleic acids encoding the ligands, recombinant host cells and methods for preparing the ligands.
    Type: Application
    Filed: July 13, 2011
    Publication date: January 24, 2013
    Inventors: Neil D. Brewis, Benjamin P. Woolven, Steven Holmes, Ian M. Tomlinson, Jennifer Lee, Carolyn Enever, Amrik Basran, Kate Jones, Ruud de Wildt, Stanislas Blein
  • Humanized antibodies specific for von Willebrand factor
    Patent number: 8236315
    Abstract: The present disclosure relates to humanized antibodies or binding fragments thereof specific for human von Willebrand factor (vWF), methods for their preparation and use, including methods for treating vWF mediated diseases or disorders.
    Type: Grant
    Filed: January 23, 2009
    Date of Patent: August 7, 2012
    Assignee: Glenmark Pharmaceuticals, S.A.
    Inventors: Elias Lazarides, Catherine Woods, Xiaomin Fan, Samuel Hou, Harald Mottl, Stanislas Blein, Martin Bertschinger
  • Humanized antibodies that bind to CD19 and their uses
    Publication number: 20100215651
    Abstract: The present invention relates to humanized antibodies or fragments thereof that bind to human CD19. More specifically, the present invention relates to a humanized antibody or fragment thereof that binds to human CD19 comprising a heavy chain CDR1 comprising the amino acid sequence of SEQ ID NO: 27, and/or a heavy chain CDR2 comprising the amino acid sequence of SEQ ID NO: 28, and/or a heavy chain CDR3 comprising the amino acid sequence of SEQ ID NO: 29; and/or comprising a light chain CDR1 comprising the amino acid sequence of SEQ ID NO: 30, and/or a light chain CDR2 comprising the amino acid sequence of SEQ ID NO: 31 and/or a light chain CDR3 comprising the amino acid sequence of SEQ ID NO: 32.
    Type: Application
    Filed: February 23, 2010
    Publication date: August 26, 2010
    Applicant: GLENMARK PHARMACEUTICALS S.A.
    Inventors: STANISLAS BLEIN, DARKO SKEGRO, CHRISTOPHE DEBONNEVILLE, MARTIN BERTSCHINGER
  • HUMANIZED ANTIBODIES SPECIFIC FOR VON WILLEBRAND FACTOR
    Publication number: 20090232804
    Abstract: The present disclosure relates to humanized antibodies or binding fragments thereof specific for human von Willebrand factor (vWF), methods for their preparation and use, including methods for treating vWF mediated diseases or disorders.
    Type: Application
    Filed: January 23, 2009
    Publication date: September 17, 2009
    Applicant: GLENMARK PHARMACEUTICALS, S.A.,
    Inventors: Elias Lazarides, Catherine Woods, Xiaomin Fan, Samuel Hou, Harald Mottl, Stanislas Blein, Martin Bertschinger