Patents by Inventor Stanislav Gobec

Stanislav Gobec has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL QUINOLIN-2-YL NITRONES USEFUL FOR THE PREVENTION AND/OR TREATMENT OF NEURODEGENERATIVE DISEASES
    Publication number: 20230382868
    Abstract: The present invention relates to the fields of medicinal chemistry and medicine, and in particular to quinolin-2-yl nitrones with the formula I as pharmaceutically active compounds. These compounds can be used as drugs for the treatment of neurodegenerative diseases by inhibiting BChE or MAO-B, either alone or in combination with other beneficial activities, such as antioxidant properties and metal chelation.
    Type: Application
    Filed: April 21, 2023
    Publication date: November 30, 2023
    Inventors: José Luis Marco Contelles, Francisco López Muñoz, Damijan Knez, Stanislav Gobec
  • N-((1-BENZYLPIPERIDIN-3-YL)METHYL)-N-(2-METHOXYETHYL)NAPHTHALENE-2-SULFONAMIDE FOR THE TREATMENT OF CANINE COGNITIVE DYSFUNCTION AND OTHER FORMS OF DEMENTIA IN DOGS
    Publication number: 20230331674
    Abstract: The present invention relates to the fields of medicinal chemistry and veterinary medicine, and in particular to N-((1-benzylpiperidin-3-yl)methyl)-N-(2-methoxyethyl)naphthalene-2-sulfonamide as a pharmaceutically active compound. The compound of the present invention has been proven for the first time to be particularly useful for the treatment of canine cognitive dysfunction and other forms of dementia in dogs which may be therapeutically modified by altering the activity of butyrylcholinesterase.
    Type: Application
    Filed: September 21, 2021
    Publication date: October 19, 2023
    Inventors: Maja ZakoSek, Sonja Prpar Mihevc, Gregor Majdic, Urban Ko{hacek over (s)}ak, Stanislav Gobec
  • Disubstituted piperidines as butyrylcholinesterase inhibitors
    Patent number: 10071964
    Abstract: This invention relates to new inhibitors of butyrylcholinesterase with general formulas I and II, where substituents are described in patent description. Compounds can be in the form of pure enantiomers or as racemic mixtures, or in the form of pharmaceutically acceptable salts. The present invention relates to the use of these inhibitors for the treatment of Alzheimer's disease and other forms of dementia.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: September 11, 2018
    Assignee: UNIVERZA V LJUBJIANI
    Inventors: Boris Brus, Urban Kosak, Damijan Knez, Nicolas Coquelle, Jacques-Philippe Colletier, Stanislav Gobec
  • DISUBSTITUTED PIPERIDINE DERIVATIVES AS BUTYRYLCHOLINESTERASE INHIBITORS FOR USE IN THE TREATMENT OF ALZHEIMER
    Publication number: 20180086707
    Abstract: This invention relates to new inhibitors of butyrylcholinesterase with general formulas I and II, where substituents are described in patent description. Compounds can be in the form of pure enantiomers or as racemic mixtures, or in the form of pharmaceutically acceptable salts. The present invention relates to the use of these inhibitors for the treatment of Alzheimer's disease and other forms of dementia.
    Type: Application
    Filed: March 22, 2016
    Publication date: March 29, 2018
    Inventors: Boris BRUS, Urban KOSAK, Damijan KNEZ, Nicolas COQUELLE, Jacques-Philippe COLLETIER, Stanislav GOBEC
  • PROCESS FOR THE SYNTHESIS OF EZETIMIBE AND INTERMEDIATES USEFUL THEREFOR
    Publication number: 20110183956
    Abstract: The present invention discloses novel and useful intermediates for the synthesis of ezetimibe (EZT), which intermediates share a characteristic Z-isomeric structure. Based on Z-5-(4-fluorophenyl)-pent-4-enoic acid, and proceeding the synthesis through further Z-intermediates, a total synthesis is presented to obtained final ezetimibe in high yields.
    Type: Application
    Filed: July 29, 2009
    Publication date: July 28, 2011
    Inventors: Janez Mravljak, Matej Sova, Andreja Kovac, Stanislav Gobec, Zdenko Casar