Patents by Inventor Stanislav S. Dukhin
Stanislav S. Dukhin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240042116Abstract: Embodiments of the invention pertain to cartridges, systems and methods for performing hemodialysis and related extracorporeal blood treatment modalities and therapies, in which blood flows in the inter fiber space and dialysate flows in the lumens of hollow fibers. Appropriate connectors and fitting orientations may be provided. There may be provided orbital distributors, fanning of fibers, and features to promote uniformity of fiber spacing in the fiber bundle. Orbital distributors may contain contoured surfaces, flow redirectors, non-uniform-conductance flow elements, through-wall distributors, and other features. There may be subdivision of the fiber bundle into two groups of fibers with separate control fluid to each group. Appropriate systems may be provided for various therapies. Flow past the fibers may be parallel, transverse or other configuration.Type: ApplicationFiled: April 10, 2023Publication date: February 8, 2024Inventors: Mohamed E. Labib, Stanislav S. Dukhin, Thomas Kelly, Peter Materna
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Publication number: 20240010949Abstract: Provided among other things is a cleaning composition comprising: a carrier fluid; and Minute Fibrils suspended in the carrier fluid, wherein the composition is protein cleaning effective.Type: ApplicationFiled: May 2, 2023Publication date: January 11, 2024Inventors: Mohamed Emam Labib, Stanislav S. Dukhin, Yacoob Tabani, Ching-Yue Lai, James L. Manganaro, Peter Materna, Jeffrey C. Robertson
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Patent number: 11701622Abstract: A cartridge is provided for dialysis or other blood processing therapy. In the cartridge, fibers may be substantially uniformly distributed near a midplane, but near an end, in the inter fiber space, there may be void flow channels, which may cause fluid flow in the inter fiber space to transition within a short region to uniform flow with minimal stagnation zones. Void flow channels may be be radially oriented, introducing fluid from the outer circumference, or axially oriented, introducing fluid along the axial direction through passageways through the potting material. The fluid flow in the inter fiber space may be perpendicular to the fibers, or radial with respect to a cartridge longitudinal axis. The cartridge may have blood flow in the inter fiber space, and flow of dialysate or ultrafiltrate in the lumens of the fibers, or the opposite situation.Type: GrantFiled: August 30, 2019Date of Patent: July 18, 2023Assignee: Novaflux Inc.Inventors: Mohamed E. Labib, Stanislav S. Dukhin, Jeffrey C. Robertson
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Patent number: 11680226Abstract: Provided among other things is a cleaning composition comprising: a carrier fluid; and Minute Fibrils suspended in the carrier fluid, wherein the composition is protein cleaning effective.Type: GrantFiled: May 5, 2022Date of Patent: June 20, 2023Assignee: Novaflux, Inc..Inventors: Mohamed Emam Labib, Stanislav S. Dukhin, Yacoob Tabani, Ching-Yue Lai, James L. Manganaro, Peter Materna, Jeffrey C. Robertson
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Patent number: 11648341Abstract: Embodiments of the invention pertain to cartridges, systems and methods for performing hemodialysis and related extracorporeal blood treatment modalities and therapies, in which blood flows in the inter fiber space and dialysate flows in the lumens of hollow fibers. Appropriate connectors and fitting orientations may be provided. There may be provided orbital distributors, fanning of fibers, and features to promote uniformity of fiber spacing in the fiber bundle. Orbital distributors may contain contoured surfaces, flow redirectors, non-uniform-conductance flow elements, through-wall distributors, and other features. There may be subdivision of the fiber bundle into two groups of fibers with separate control fluid to each group. Appropriate systems may be provided for various therapies. Flow past the fibers may be parallel, transverse or other configuration.Type: GrantFiled: September 26, 2019Date of Patent: May 16, 2023Assignee: Novaflux Inc.Inventors: Mohamed E. Labib, Stanislav S. Dukhin, Thomas Kelly, Peter Materna
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Publication number: 20230093577Abstract: In embodiments of the invention, there is provided a dialyzer or filter comprising hollow fibers, in which blood flows on the exterior of the hollow fibers, and dialysate or filtrate may flow on the inside. The external surfaces of the hollow fibers may have properties of smoothness and hemocompatibility. The fiber bundle may have appropriate packing fraction and may have wavy fibers. Optimum shear rates and blood velocities are identified. Geometric features of the cartridge, such as pertaining to flow distribution of the blood, may be different for different ends of the cartridge. Air bleed and emboli traps may be provided. Lengthened service life may be achieved by combinations of these features, which may permit additional therapies and applications or better economics.Type: ApplicationFiled: August 11, 2022Publication date: March 23, 2023Inventors: Mohamed E. Labib, Stanislav S. Dukhin
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Publication number: 20220396752Abstract: Provided among other things are a cleaning composition comprising a carrier fluid comprising in the carrier fluid polymer comprising particulate super absorbent polymer (PSAP), wherein the PSAP as in the cleaning composition is substantially at the percolation volume fraction or higher; wherein the cleaning composition can be passed over a surface driven by a pressure drop effective to render the composition traditional biofilm (TBF) cleaning effective and protein cleaning effective.Type: ApplicationFiled: May 23, 2022Publication date: December 15, 2022Inventors: Mohamed Emam Labib, Stanislav S. Dukhin, Yacoob Tabani, Ching-Yue Lai, James L. Manganaro, Peter Materna, Jeffrey C. Robertson, Seo Yean Sohn
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Patent number: 11446419Abstract: In embodiments of the invention, there is provided a dialyzer or filter comprising hollow fibers, in which blood flows on the exterior of the hollow fibers, and dialysate or filtrate may flow on the inside. The external surfaces of the hollow fibers may have properties of smoothness and hemocompatibility. The fiber bundle may have appropriate packing fraction and may have wavy fibers. Optimum shear rates and blood velocities are identified. Geometric features of the cartridge, such as pertaining to flow distribution of the blood, may be different for different ends of the cartridge. Air bleed and emboli traps may be provided. Lengthened service life may be achieved by combinations of these features, which may permit additional therapies and applications or better economics.Type: GrantFiled: July 2, 2019Date of Patent: September 20, 2022Assignee: Novaflux Inc.Inventors: Mohamed E. Labib, Stanislav S. Dukhin
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Publication number: 20220267698Abstract: Provided among other things is a cleaning composition comprising: a carrier fluid; and Minute Fibrils suspended in the carrier fluid, wherein the composition is protein cleaning effective.Type: ApplicationFiled: May 5, 2022Publication date: August 25, 2022Inventors: Mohamed Emam Labib, Stanislav S. Dukhin, Yacoob Tabani, Ching-Yue Lai, James L. Manganaro, Peter Materna, Jeffrey C. Robertson
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Patent number: 11345878Abstract: Provided among other things are a cleaning composition comprising a carrier fluid comprising in the carrier fluid polymer comprising particulate super absorbent polymer (PSAP), wherein the PSAP as in the cleaning composition is substantially at the percolation volume fraction or higher; wherein the cleaning composition can be passed over a surface driven by a pressure drop effective to render the composition traditional biofilm (TBF) cleaning effective and protein cleaning effective.Type: GrantFiled: April 3, 2019Date of Patent: May 31, 2022Assignee: Novaflux Inc.Inventors: Mohamed Emam Labib, Stanislav S. Dukhin, Yacoob Tabani, Ching-Yue Lai, James L. Manganaro, Peter Materna, Jeffrey C. Robertson, Seo Yean Sohn
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Patent number: 11326128Abstract: Provided among other things is a cleaning composition comprising: a carrier fluid; and Minute Fibrils suspended in the carrier fluid, wherein the composition is protein cleaning effective.Type: GrantFiled: February 19, 2019Date of Patent: May 10, 2022Assignee: Novaflux, Inc.Inventors: Mohamed Emam Labib, Stanislav S. Dukhin, Yacoob Tabani, Ching-Yue Lai, James L. Manganaro, Peter Materna, Jeffrey C. Robertson
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Publication number: 20220008335Abstract: Hollow fiber drug delivery devices are described. Device can contain structural or solid fibers. Fabric can be formed by fibers being interwoven or joined to each other. All or some of the fibers can be resorbable. Fibers can be subdivided, by deformations or closure points, into numerous compartments that separately deliver drug. Deformations can be located at points of fiber intersection or joining. Different drug or drug formulation can be provided in different places. Fibers can be given appropriate surface treatments or coatings to achieve desired properties such as wetting of pores and surfaces. Different release characteristics in different directions can be achieved. The hollow fibers can contain solid particles of drug, and can contain gel. Possible applications include hernia meshes, pouches, sutures, catheters, wound dressings, stents, nerve regrowth guides, refillable/drainable devices, and devices that deliver drug to lymphatic flow.Type: ApplicationFiled: March 18, 2021Publication date: January 13, 2022Inventors: Mohamed E. Labib, Stanislav S, Dukhin, Peter Materna, Jeffrey C. Robertson, Ching-Yue Lai, Yacoob Tabani
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Patent number: 11191613Abstract: Provided among other things is a sampling system for determining an amount or type of contamination a narrow, elongated passageway in a medical device, said sampling system comprising: (a) a fluid supply system that supplies to said passageway a sampling liquid for flowing through said passageway and a gas for flowing through said passageway; and (b) a receiving container that receives liquid from said passageway, wherein said sampling liquid is sterile, wherein said sampling liquid is configured to allow recovery of viable pathogens from the passageway, and wherein said sampling liquid comprises an amount and selection of surfactant effective to enhance the dislodgement of Enterococcus faecalis and Pseudomonas aeruginosa bacteria from the narrow passageways.Type: GrantFiled: August 29, 2019Date of Patent: December 7, 2021Assignee: Novaflux, Inc.Inventors: Mohamed E. Labib, Stanislav S. Dukhin, Jeffrey C. Robertson, Peter Materna, Ching-Yue Lai, Yacoob Tabani
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Publication number: 20210290764Abstract: Methods of preventing and treating an ear infection comprising insertion of a tympanostomy tube comprised of a least one anti-biotic agentType: ApplicationFiled: June 9, 2021Publication date: September 23, 2021Inventors: Mohamed Emam Labib, Stanislav S. Dukhin
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Patent number: 11033624Abstract: Methods of preventing and treating an ear infection comprising insertion of a tympanostomy tube comprised of a least one anti-biotic agent.Type: GrantFiled: June 5, 2014Date of Patent: June 15, 2021Assignee: Novaflux Inc.Inventors: Mohamed Emam Labib, Stanislav S. Dukhin
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Patent number: 10952961Abstract: Hollow fiber drug delivery devices are described. Device can contain structural or solid fibers. Fabric can be formed by fibers being interwoven or joined to each other. All or some of the fibers can be resorbable. Fibers can be subdivided, by deformations or closure points, into numerous compartments that separately deliver drug. Deformations can be located at points of fiber intersection or joining. Different drug or drug formulation can be provided in different places. Fibers can be given appropriate surface treatments or coatings to achieve desired properties such as wetting of pores and surfaces. Different release characteristics in different directions can be achieved. The hollow fibers can contain solid particles of drug, and can contain gel. Possible applications include hernia meshes, pouches, sutures, catheters, wound dressings, stents, nerve regrowth guides, refillable/drainable devices, and devices that deliver drug to lymphatic flow.Type: GrantFiled: December 12, 2019Date of Patent: March 23, 2021Assignee: Novaflux, Inc.Inventors: Mohamed E. Labib, Stanislav S. Dukhin, Peter Materna, Jeffrey C. Robertson, Ching-Yue Lai, Yacoob Tabani
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Publication number: 20200270551Abstract: Provided among other things are a cleaning composition comprising a carrier fluid comprising in the carrier fluid polymer comprising particulate super absorbent polymer (PSAP), wherein the PSAP as in the cleaning composition is substantially at the percolation volume fraction or higher; wherein the cleaning composition can be passed over a surface driven by a pressure drop effective to render the composition traditional biofilm (TBF) cleaning effective and protein cleaning effective.Type: ApplicationFiled: April 3, 2019Publication date: August 27, 2020Inventors: Mohamed Emam LABIB, Stanislav S. DUKHIN, Yacoob TABANI, Ching-Yue LAI, James L. MANGANARO, Peter MATERNA, Jeffrey C. ROBERTSON, Seo Yean SOHN
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Publication number: 20200197595Abstract: Embodiments of the invention pertain to cartridges, systems and methods for performing hemodialysis and related extracorporeal blood treatment modalities and therapies, in which blood flows in the inter fiber space and dialysate flows in the lumens of hollow fibers. Appropriate connectors and fitting orientations may be provided. There may be provided orbital distributors, fanning of fibers, and features to promote uniformity of fiber spacing in the fiber bundle. Orbital distributors may contain contoured surfaces, flow redirectors, non-uniform-conductance flow elements, through-wall distributors, and other features. There may be subdivision of the fiber bundle into two groups of fibers with separate control fluid to each group. Appropriate systems may be provided for various therapies. Flow past the fibers may be parallel, transverse or other configuration.Type: ApplicationFiled: September 26, 2019Publication date: June 25, 2020Inventors: Mohamed E. Labib, Stanislav S. Dukhin, Thomas Kelly, Peter Materna
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Publication number: 20200138708Abstract: Hollow fiber drug delivery devices are described. Device can contain structural or solid fibers. Fabric can be formed by fibers being interwoven or joined to each other. All or some of the fibers can be resorbable. Fibers can be subdivided, by deformations or closure points, into numerous compartments that separately deliver drug. Deformations can be located at points of fiber intersection or joining. Different drug or drug formulation can be provided in different places. Fibers can be given appropriate surface treatments or coatings to achieve desired properties such as wetting of pores and surfaces. Different release characteristics in different directions can be achieved. The hollow fibers can contain solid particles of drug, and can contain gel. Possible applications include hernia meshes, pouches, sutures, catheters, wound dressings, stents, nerve regrowth guides, refillable/drainable devices, and devices that deliver drug to lymphatic flow.Type: ApplicationFiled: December 12, 2019Publication date: May 7, 2020Inventors: Mohamed E. LABIB, Stanislav S. DUKHIN, Peter MATERNA, Jeffrey C. ROBERTSON, Ching-Yue LAI, Yacoob TABANI
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Publication number: 20200129929Abstract: A cartridge is provided for dialysis or other blood processing therapy. In the cartridge, fibers may be substantially uniformly distributed near a midplane, but near an end, in the inter fiber space, there may be void flow channels, which may cause fluid flow in the inter fiber space to transition within a short region to uniform flow with minimal stagnation zones. Void flow channels may be be radially oriented, introducing fluid from the outer circumference, or axially oriented, introducing fluid along the axial direction through passageways through the potting material. The fluid flow in the inter fiber space may be perpendicular to the fibers, or radial with respect to a cartridge longitudinal axis. The cartridge may have blood flow in the inter fiber space, and flow of dialysate or ultrafiltrate in the lumens of the fibers, or the opposite situation.Type: ApplicationFiled: August 30, 2019Publication date: April 30, 2020Inventors: Mohamed E. Labib, Stanislav S. Dukhin, Jeffrey C. Robertson