Abstract: Methods for controlling catalysis of a chemical reaction generally includes electrostatically controlling position of a first linear single-molecule polymer inside at least one nanopore fluidly coupled to a reaction chamber comprising a reaction medium and at least one reactant, wherein the first linear single-molecule polymer is coupled to a first catalyst at one end and includes one or more charged sub-units; and creating an electrostatic potential well inside the nanopore, wherein the electrostatic potential well controls a position of the first linear single-molecule polymer inside the at least one nanopore. Also disclosed are apparatuses for controlling catalysis of the chemical reaction.