Patents by Inventor Stanley A. Stein

Stanley A. Stein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Carrier for in vivo delivery of a therapeutic agent
    Patent number: 6258774
    Abstract: A carrier for in vivo delivery of a therapeutic agent comprising a thiol group is provided, wherein the therapeutic agent is conjugated to the carrier via a biodegradable disulfide bond. Since extracellular fluids in vivo do not provide the appropriate environment to efficiently reduce a disulfide bond, while cellular cytosol does provide an appropriate environment, the agent will remain substantially coupled to the carrier while circulating through the body until the carrier crosses a cell membrane. As a result, the therapeutic agent is protected from degradation and renal clearance, and the potential for the therapeutic agent to elicit an immune response is limited.
    Type: Grant
    Filed: March 19, 1998
    Date of Patent: July 10, 2001
    Assignee: University of Medicine and Dentistry of New Jersey
    Inventors: Stanley Stein, Michael J. Leibowitz, Patrick J. Sinko
  • Site-specific 13C-enriched reagents for diagnostic medicine by magnetic resonance imaging
    Patent number: 6210655
    Abstract: The present invention relates to site-specific 13C-enriched reagents for diagnostic medicine for magnetic resonance imaging. The site-specific 13C-enriched reagents may be represented by the formula: T-L-R. T is a site-specific targeting group which selectively binds to a disease-related target in an animal or human, R is an inert polymer containing repeating 13C reporting groups which provide a magnetic resonance imaging signal, and L is a linker group which connects the site-specific targeting group to the inert polymer. The site-specific 13C-enriched reagents are targeted to and capable of identifying, quantifying, and localizing disease-specific loci, such as blood clots, &bgr;-amyloid plaques of Alzheimer's disease, and tumors through the use of magnetic resonance imaging. The present invention also pertains to a method for employing the site-specific 13C-enriched reagents in a living mammal.
    Type: Grant
    Filed: June 18, 1997
    Date of Patent: April 3, 2001
    Assignee: University of Medicine & Dentistry of NJ
    Inventor: Stanley Stein
  • Enkephalin-like compounds in bovine adrenal medulla
    Patent number: 4388236
    Abstract: Enkephalin-like compounds having opiate agonist activity and useful as analgesic agents are extracted from bovine adrenal glands.
    Type: Grant
    Filed: May 4, 1982
    Date of Patent: June 14, 1983
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Stanley Stein
  • Enkephalin-like compounds in bovine adrenal medulla
    Patent number: 4264492
    Abstract: Enkephalin-like compounds can be extracted from bovine adrenal glands, showing opiate agonist activity and immunoreactive with enkephalin antibodies.
    Type: Grant
    Filed: August 30, 1979
    Date of Patent: April 28, 1981
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Stanley Stein
  • Liquid chromatography system
    Patent number: 4116046
    Abstract: A liquid chromatography system comprises the following major components in combination: gas pressurized buffer reservoirs, automatic buffer selection valve, mixer/debubbler chamber, pump means, automatic sample valve, chromatography column, detector and fraction collector.
    Type: Grant
    Filed: August 5, 1977
    Date of Patent: September 26, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Stanley Stein
  • Baby food storing and dispensing spoon
    Patent number: D371491
    Type: Grant
    Filed: February 24, 1994
    Date of Patent: July 9, 1996
    Inventor: Stanley A. Stein