Patents by Inventor Stanley Belkowski

Stanley Belkowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of determining chymase activity with secretory leukocyte protease inhibitor
    Patent number: 7892779
    Abstract: It is now discovered that human chymase cleaves human SLPI at a specific site and that this cleavage can be used as an indicator of chymase activity. The present invention provides methods of diagnosing a chymase-associated disease or evaluating the efficiency of a treatment of a chymase-associated disease in a human subject by measuring SLPI processing, as well as other related methods and compositions.
    Type: Grant
    Filed: July 9, 2009
    Date of Patent: February 22, 2011
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Stanley Belkowski, Michael R. D'Andrea
  • Method of determining chymase activity with secretory leukocyte protease inhibitor
    Publication number: 20090275068
    Abstract: It is now discovered that human chymase cleaves human SLPI at a specific site and that this cleavage can be used as an indicator of chymase activity. The present invention provides methods of diagnosing a chymase-associated disease or evaluating the efficiency of a treatment of a chymase-associated disease in a human subject by measuring SLPI processing, as well as other related methods and compositions.
    Type: Application
    Filed: July 9, 2009
    Publication date: November 5, 2009
    Inventors: Stanley Belkowski, Michael R. D'Andrea
  • Method of determining chymase activity with secretory leukocyte protease inhibitor
    Patent number: 7575888
    Abstract: It is now discovered that human chymase cleaves human SLPI at a specific site and that this cleavage can be used as an indicator of chymase activity. The present invention provides methods of diagnosing a chymase-associated disease or evaluating the efficiency of a treatment of a chymase-associated disease in a human subject by measuring SLPI processing, as well as other related methods and compositions.
    Type: Grant
    Filed: January 12, 2007
    Date of Patent: August 18, 2009
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Stanley Belkowski, Michael R. D'Andrea
  • Processing of SLPI by chymase
    Publication number: 20070166779
    Abstract: It is now discovered that human chymase cleaves human SLPI at a specific site and that this cleavage can be used as an indicator of chymase activity. The present invention provides methods of diagnosing a chymase-associated disease or evaluating the efficiency of a treatment of a chymase-associated disease in a human subject by measuring SLPI processing, as well as other related methods and compositions.
    Type: Application
    Filed: January 12, 2007
    Publication date: July 19, 2007
    Inventors: Stanley Belkowski, Michael D'Andrea
  • Immobilized N-substituted tricyclic 3-aminopyrazoles for the identification of biomolecular targets
    Publication number: 20050130910
    Abstract: The present invention relates to immobilized N-substituted tricyclic 3-aminopyrazole compounds of Formula 1 as tools for the identification of bimolecular targets in cells of therapeutic significance, profiling the selectivity of compounds, prediction of possible related toxicities and exploration of mechanisms of action in biological systems for therapeutic indications related to compounds. These agents can be used to identify biomolecules with the potential to interact with the immobilized reagent. The identified biomolecule may be then be used as a therapeutic target, serve as a marker of drug action, or alternatively describe an untoward or toxic potential of the immobilized agent.
    Type: Application
    Filed: November 10, 2004
    Publication date: June 16, 2005
    Inventors: Chih Ho, Robert Galemmo, Dana Johnson, Jay Mei, Stanley Belkowski, Richard Connors