Abstract: Dosage forms of a pharmaceutical composition comprising a sealed actives compartment containing a stable prostaglandin in a pharmaceutical composition for topical application to a patient are disclosed. Preferably, the prostaglandin compound is substantially uniformly dispersed in a delivery vehicle, and in certain embodiments the prostaglandin compound contains stabilizing agent comprising a moisture scavenger, an antioxidant and a chelating agent for metal ions. In certain embodiments the delivery vehicle is preferably substantially anhydrous, free of metal ions and oxygen and water. The improved compositions of the present invention are useful for treating medical conditions by providing a packed mono or multi-component dosage form that comprises a sealed section containing an active pharmaceutical ingredient and a delivery vehicle pharmaceutically compatible for topical delivery. The medical condition can be, for example male or female sexual dysfunction broadly and male erectile dysfunction specifically.

Abstract: A dual action antifungal nail coat composition and method of use for ameliorating or preventing fungal infection of the nails, and onychomycosis, in particular, is disclosed. Composition embodiments in the form of one-coat type and two-coat type suitable for daily fungicidal regimens are disclosed. A preferred antifungal nail coat composition comprises an effective fungicidal amount of antifungal agent, a permeation enhancing amount of a substantially non-volatile, permeation enhancer, a film-forming amount of a hydrophilic polymer, and a pharmaceutically acceptable, volatile carrier. The composition provides a substantially water-soluble fungicidal coating on contacting a fungally susceptible or infected nail.