Abstract: This disclosure relates to skin tissue systems, devices, and methods. Systems described include ones comprising: a tissue sample; an insert; and a porous layer configured to promote mass transport into the tissue sample; wherein the skin tissue system is capable of supporting tissue viability for at least one week. Methods described include ones for skin tissue analysis comprising: contacting a skin tissue array with at least one test agent; measuring a plurality of datasets following the contacting; mapping the plurality of datasets based on a scoring panel result; and generating at least one threshold criteria for selecting the therapeutic agent from the at least one test agent based on the mapped datasets. Such innovations described herein provide for an ex vivo model tissue system and use of the model tissue system for analytical activities such as screening of nutrients, pharmaceutical activity, and toxicity in tissue samples.

Abstract: A guide assembly for sawing an elongate member accurately to length to form the sides of a picture frame comprises two saw-guide units which are adjustably clamped to two guide roads by means of screws. The picture frame glass is placed between reference surfaces of blocks on the saw-guide units to determine the required distance apart of the two saw-guide units. Each saw-guide unit has two pairs of posts defining slots therebetween for the blade of a saw, to hold the saw-blade accurately at 45.degree. to the direction of elongation of the wooden member, for the eventual formation of mitred joints between the sides of the picture frame. Each saw-guide unit includes a special ridge to abut that surface of the wooden member which is to surround the edge of the glass.