Patents by Inventor Stanley L. Mish
Stanley L. Mish has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6471687Abstract: This invention relates generally to an implantable containment apparatus made of selectively permeable material. In particular, the implantable containment apparatus is used to contain a therapeutical device, a cell encapsulation device, or a gene therapy device. A therapeutical device can be easily placed and replaced in an apparatus of the present invention without damaging tissues associated with the selectively permeable material of the apparatus.Type: GrantFiled: November 30, 1998Date of Patent: October 29, 2002Assignee: Gore Enterprise Holdings, Inc.Inventors: Mark D. Butler, Daniel F. Davidson, Stanley L. Mish, James W. Moore, III
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Patent number: 6426214Abstract: Cell encapsulating devices capable of maintaining large numbers of viable cells are provided containing an inert, substantially cell-free core that displaces cells, a permeable membrane and a zone for maintaining cells. The permeable membrane surrounds the core such that the zone of cells is bounded by the core and the permeable membrane. A preferred device contains a polytetrafluoroethylene permeable membrane and a flexible polymer core having a plurality of ridges and valleys running lengthwise along the core. The cell zone may contain support means for cell attachment and the core may have an outer boundary containing a material that promotes cell adhesion. Preferably, the cell zone has a thickness such that at least about 10% of the cells, more preferably at least about 50% or 80%, in a cell layer located closest to the outer boundary of the core remain viable. The thickness is preferably less than 500 microns such as 25 to 250 microns or 50 to 100 microns.Type: GrantFiled: November 8, 1999Date of Patent: July 30, 2002Assignee: Gore Enterprise Holdings, Inc.Inventors: Mark D. Butler, Stanley L. Mish
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Publication number: 20020049426Abstract: This invention relates generally to an implantable containment apparatus made of selectively permeable material. In particular, the implantable containment apparatus is used to contain a therapeutical device, such as a drug delivery device, a cell encapsulation device, or a gene therapy device. A therapeutical device can be easily placed and replaced in an apparatus of the present invention without damaging tissues associated with the selectively permeable material of the apparatus.Type: ApplicationFiled: November 30, 1998Publication date: April 25, 2002Inventors: MARK D. BUTLER, DANIEL F. DAVIDSON, STANLEY L. MISH, JAMES W. MOORE
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Patent number: 6306491Abstract: The present invention is directed to materials that assist respiration of living cells contained in cell-containing systems. The materials form air-filled conduits or channels through which gases, such as oxygen and carbon dioxide, can readily exchange by diffusional means between regions of different gas partial pressures. When the present invention is placed within an aqueous environment, such as cell-culture media or host tissue, the invention provides aid to cellular respiration in cell-containing systems.Type: GrantFiled: March 31, 1999Date of Patent: October 23, 2001Assignee: Gore Enterprise Holdings, Inc.Inventors: Brian H. Kram, Stanley L. Mish, Michael J. Muehlbauer, James R. Bain
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Patent number: 5980889Abstract: Cell encapsulating devices capable of maintaining large numbers of viable cells are provided containing an inert, substantially cell-free core that displaces cells, a permeable membrane and a zone for maintaining cells. The permeable membrane surrounds the core such that the zone of cells is bounded by the core and the permeable membrane. The cell zone may contain a support means for cell attachment and the core may have an outer boundary containing a material that promotes cell adhesion. Preferably, the cell zone has a thickness such that at least about 10% of the cells, more preferably at least about 50% or 80%, in a cell layer located closest to the outer boundary of the core remain viable. The thickness is preferably less than 500 microns such as 25 to 250 microns or 50 to 100 microns. The devices are suitable for implantation into an individual in need of treatment and are capable of supplying therapeutic substances to such individuals.Type: GrantFiled: August 5, 1997Date of Patent: November 9, 1999Assignee: Gore Hybrid Technologies, Inc.Inventors: Mark D. Butler, Stanley L. Mish
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Patent number: 5913998Abstract: This invention relates generally to an implantable containment apparatus made of selectively permeable material. In particular, the implantable containment apparatus is used to contain a therapeutical device, such as a drug delivery device, a cell encapsulation device, or a gene therapy device. A therapeutical device can be easily placed and replaced in an apparatus of the present invention without damaging tissues associated with the selectively permeable material of the apparatus.Type: GrantFiled: January 9, 1997Date of Patent: June 22, 1999Assignee: Gore Hybrid Technologies, Inc.Inventors: Mark D. Butler, Daniel F. Davidson, Stanley L. Mish
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Patent number: 5902745Abstract: The present invention is directed to a cell encapsulation device that permits rapid and straightforward cell transfer into the device. The preferred device includes components that allow a user to quickly transfer cells into the device with minimal risk to the cells. Among the most important improvements of the present invention are: automatic filtration of excess solution during cell transfer; an instantly wettable cover, allowing ready view into the cell chamber; and a swellable core, allowing cells to be transferred with minimal shear force while assuring optimal cell placement in the device during use. The device of the present invention may be used either in vivo, such as to deliver therapeutic substances, or in vitro, such as to serve as a bioreactor.Type: GrantFiled: May 21, 1997Date of Patent: May 11, 1999Assignee: Gore Hybrid Technologies, Inc.Inventors: Mark D. Butler, Paul D. Drumheller, Stanley L. Mish
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Patent number: 5843069Abstract: This invention relates generally to an implantable containment apparatus made of selectively permeable material. In particular, the implantable containment apparatus is used to contain a therapeutical device, such as a drug delivery device, a cell encapsulation device, or a gene therapy device. A therapeutical device can be easily placed and replaced in an apparatus of the present invention without damaging tissues associated with the selectively permeable material of the apparatus.Type: GrantFiled: July 10, 1997Date of Patent: December 1, 1998Assignee: Gore Hybrid Technologies, Inc.Inventors: Mark D. Butler, Daniel F. Davidson, Stanley L. Mish, James W. Moore, III
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Patent number: 5787900Abstract: This invention relates generally to a method of loading and reloading a therapeutical device in a vascularized implantable containment apparatus made of selectively permeable material. Suitable therapeutical devices for use in the present invention include devices such as drug delivery devices, cell encapsulation devices, or gene therapy devices. A therapeutical device can be easily placed and replaced in a vascularized apparatus of the present invention without damaging tissues associated with the selectively permeable material of the apparatus.Type: GrantFiled: October 11, 1996Date of Patent: August 4, 1998Assignee: Gore Hybrid Technologies, Inc.Inventors: Mark D. Butler, Stanley L. Mish
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Patent number: 5626561Abstract: This invention relates generally to an implantable containment apparatus made of selectively permeable material. In particular, the implantable containment apparatus is used to contain a therapeutical device, such as a drug delivery device, a cell encapsulation device, or a gene therapy device. A therapeutical device can be easily placed and replaced in an apparatus of the present invention without damaging tissues associated with the selectively permeable material of the apparatus.Type: GrantFiled: June 7, 1995Date of Patent: May 6, 1997Assignee: Gore Hybrid Technologies, Inc.Inventors: Mark D. Butler, Stanley L. Mish
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Patent number: 5472081Abstract: A suture needle holder for a suture package intended to contain an armed suture, comprising a sheet of planar plastic having at least one raised pedestal formed therein, said at least one raised pedestal having at least one slot therein oriented orthogonal to the sheet of planar plastic, said at least one slot having an open portion and a needle-holding portion releasably holding a portion of the length of a suture needle therein with the length of the suture needle lying in a plane parallel to the sheet of planar plastic, wherein the open portion of the slot is of a width narrower than the diameter of the length portion of the suture needle held within the needle-holding portion of the slot. A method of forming the suture needle holder is also described.Type: GrantFiled: May 16, 1994Date of Patent: December 5, 1995Assignee: W. L. Gore & Associates, Inc.Inventors: Bret J. Kilgrow, Stanley L. Mish
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Patent number: 5192483Abstract: A method of forming a suture needle holder for a suture needle. A suture needle is placed in a trough cut into the surface of a die. This trough intersects a cavity within the die. A sheet is placed onto the surface of the die after the needle is placed in the trough. The sheet is then thermoformed into the cavity to form a pedestal around the needle. During thermoforming the needle is captured by the sheet and a slot is formed about the suture needle.Type: GrantFiled: December 2, 1991Date of Patent: March 9, 1993Assignee: W. L. Gore & Associates, Inc.Inventors: Bret J. Kilgrow, Stanley L. Mish
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Patent number: 5086914Abstract: A suture package comprising a housing surrounding a cavity and having a port through some portion of the housing, wherein said cavity contains a length of suture in a configuration sequentially ordered along the suture withdrawal path but otherwise random. In a preferred embodiment the cavity has a vent through a portion of the housing to allow the use of a gaseous flow to aid in the loading of the length of suture into the cavity. A method of suture packaging is also described.Type: GrantFiled: May 14, 1990Date of Patent: February 11, 1992Assignee: W. L. Gore & Associates, Inc.Inventors: Stanley L. Mish, James D. Silverman