Abstract: Compositions and methods for efficient cellular genomic engineering that transduce diverse cell types with minimal toxicity, leading to efficient and stable genomic modifications are described. The compositions and methods are applicable to development of chimeric antigen receptor engineered T cell therapy (CAR-T). An exemplary method introduces a gene of interest into cells by introducing to the cell a viral vector including a transposon encoding the gene of interest and mRNA including a sequence that encodes transposase enzymes configured to mediate targeted integration of the transposon into the cellular genome, whereby the mRNA is introduced to the cell via electroporation. Also disclosed are genetically modified cells and pharmaceutical compositions and methods of use thereof for treating subjects having diseases or disorders.

Abstract: Methods and apparatus for directing light into an environment are described, for example methods and apparatus for use in a light detection and ranging system that scans light across an environment for spatial estimation. The method and system involves scanning at one angular resolution and temporal resolution in a first scan and scanning at a different angular resolution and temporal resolution (one or both) in a second scan.

Abstract: A hair treatment composition which has a thickened fluid form comprising: (i) a first (shear gel) phase comprising at least one naturally derived polymer which is capable of forming a reversible gel, which polymer is present in the composition as a shear gel (i.e., a multiplicity of separate gel particles which have been formed by subjecting the polymer to shear while gel formation takes place), and (ii) a second (suspended) phase suspended therein.

Abstract: A shampoo composition having at least one detersive surfactant, a suspending particulate agent, and a cationic deposition polymer, wherein at least about 5% by weight of the cationic deposition polymer is adsorbed on the suspended particulate agent is described.

Abstract: The invention provides a washing composition for washing a surface to deposit thereon a solid active agent, the washing composition comprising an emulsion of silicone droplets, the silicone droplets comprising: (a) a continuous silicone phase, and; (b) a dispersed phase of solid particulate active agent. Preferably the solid active agent is a solid antimicrobial such as zinc pyridinethione.