Patents by Inventor Stanley Maloy

Stanley Maloy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • REGULATED GENETIC SUICIDE MECHANISM COMPOSITIONS AND METHODS
    Publication number: 20170224625
    Abstract: Embodiments of the present invention relates to the incorporation and use of a regulated genetic suicide mechanism for use in the improved purification of biologics, including adjunct use in various eubacterial minicell production and purification methodologies. Described herein are high-yield eubacterial minicell-producing strains with genetic modifications that comprise a regulated genetic suicide mechanism that irreparably destroys the parent cell chromosome such that live parental cells in a culture can be functionally eliminated at any time during the course of a minicell production and purification run. Embodiments of the present invention also describe methods useful in the elimination of live parental cells during the production of other cell-based biologics.
    Type: Application
    Filed: February 13, 2017
    Publication date: August 10, 2017
    Inventors: Matthew J. Giacalone, Stanley Maloy, Shingo Tsuji
  • Regulated genetic suicide mechanism compositions and methods
    Patent number: 9574196
    Abstract: Embodiments of the present invention relates to the incorporation and use of a regulated genetic suicide mechanism for use in the improved purification of biologics, including adjunct use in various eubacterial minicell production and purification methodologies. Described herein are high-yield eubacterial minicell-producing strains with genetic modifications that comprise a regulated genetic suicide mechanism that irreparably destroys the parent cell chromosome such that live parental cells in a culture can be functionally eliminated at any time during the course of a minicell production and purification run. Embodiments of the present invention also describe methods useful in the elimination of live parental cells during the production of other cell-based biologics.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: February 21, 2017
    Assignee: Vaxiion Therapeutics, LLC
    Inventors: Matthew J Giacalone, Stanley Maloy, Shingo Tsuji
  • REGULATED GENETIC SUICIDE MECHANISM COMPOSITIONS AND METHODS
    Publication number: 20150344894
    Abstract: Embodiments of the present invention relates to the incorporation and use of a regulated genetic suicide mechanism for use in the improved purification of biologics, including adjunct use in various eubacterial minicell production and purification methodologies. Described herein are high-yield eubacterial minicell-producing strains with genetic modifications that comprise a regulated genetic suicide mechanism that irreparably destroys the parent cell chromosome such that live parental cells in a culture can be functionally eliminated at any time during the course of a minicell production and purification run. Embodiments of the present invention also describe methods useful in the elimination of live parental cells during the production of other cell-based biologics.
    Type: Application
    Filed: May 28, 2015
    Publication date: December 3, 2015
    Inventors: Matthew J Giacalone, Stanley Maloy, Shingo Tsuji
  • Regulated genetic suicide mechanism compositions and methods
    Patent number: 9045761
    Abstract: Embodiments of the present invention relates to the incorporation and use of a regulated genetic suicide mechanism for use in the improved purification of biologics, including adjunct use in various eubacterial minicell production and purification methodologies. Described herein are high-yield eubacterial minicell-producing strains with genetic modifications that comprise a regulated genetic suicide mechanism that irreparably destroys the parent cell chromosome such that live parental cells in a culture can be functionally eliminated at any time during the course of a minicell production and purification run. Embodiments of the present invention also describe methods useful in the elimination of live parental cells during the production of other cell-based biologics.
    Type: Grant
    Filed: December 11, 2012
    Date of Patent: June 2, 2015
    Assignee: Vaxiion Therapeutics, LLC
    Inventors: Matthew J Giacalone, Stanley Maloy, Shingo Tsuji
  • REGULATED GENETIC SUICIDE MECHANISM COMPOSITIONS AND METHODS
    Publication number: 20100112670
    Abstract: Embodiments of the present invention relates to the incorporation and use of a regulated genetic suicide mechanism for use in the improved purification of biologics, including adjunct use in various eubacterial minicell production and purification methodologies. Described herein are high-yield eubacterial minicell-producing strains with genetic modifications that comprise a regulated genetic suicide mechanism that irreparably destroys the parent cell chromosome such that live parental cells in a culture can be functionally eliminated at any time during the course of a minicell production and purification run. Embodiments of the present invention also describe methods useful in the elimination of live parental cells during the production of other cell-based biologics.
    Type: Application
    Filed: June 23, 2009
    Publication date: May 6, 2010
    Applicant: Vaxiion Therapeutics, Inc.
    Inventors: Matthew J. Giacalone, Stanley Maloy, Shingo Tsuji