Patents by Inventor Stanley Mansfield
Stanley Mansfield has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240100361Abstract: Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.Type: ApplicationFiled: August 24, 2023Publication date: March 28, 2024Applicant: Varian Medical Systems, Inc.Inventors: Renate PARRY, Eric ABEL, Swati GIRDHANI, Stanley MANSFIELD, Patrick KUPELIAN, Deepak KHUNTIA
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Patent number: 11771920Abstract: Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.Type: GrantFiled: September 27, 2021Date of Patent: October 3, 2023Assignee: Varian Medical Systems, Inc.Inventors: Renate Parry, Eric Abel, Swati Girdhani, Stanley Mansfield, Patrick Kupelian, Deepak Khuntia
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Publication number: 20230271030Abstract: Radiation treatment planning includes accessing values of parameters such as a number of beams to be directed into sub-volumes in a target, beam directions, and beam energies. Information that specifies limits for the radiation treatment plan are accessed. The limits include a limit on irradiation time for each sub-volume outside the target. Other limits can include a limit on irradiation time for each sub-volume in the target, a limit on dose rate for each sub volume in the target, and a limit on dose rate for each sub-volume outside the target. The values of the parameters are adjusted until the irradiation time for each sub-volume outside the target satisfies the maximum limit on irradiation time.Type: ApplicationFiled: May 5, 2023Publication date: August 31, 2023Applicants: Varian Medical Systems, Inc., Siemens Healthineers International AGInventors: Reynald VANDERSTRAETEN VANDERSTRAETEN, Eric ABEL, Christel SMITH, Anthony MAGLIARI, Timo KOPONEN, Stanley MANSFIELD, Charles ADELSHEIM
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Patent number: 11673003Abstract: Radiation treatment planning includes accessing values of parameters such as a number of beams to be directed into sub-volumes in a target, beam directions, and beam energies. Information that specifies limits for the radiation treatment plan are accessed. The limits include a limit on irradiation time for each sub-volume outside the target. Other limits can include a limit on irradiation time for each sub-volume in the target, a limit on dose rate for each sub-volume in the target, and a limit on dose rate for each sub-volume outside the target. The values of the parameters are adjusted until the irradiation time for each sub-volume outside the target satisfies the maximum limit on irradiation time.Type: GrantFiled: November 6, 2020Date of Patent: June 13, 2023Assignees: VARIAN MEDICAL SYSTEMS, INC., VARIAN MEDICAL SYSTEMS INTERNATIONAL AGInventors: Reynald Vanderstraeten, Eric Abel, Christel Smith, Anthony Magliari, Timo Koponen, Stanley Mansfield, Charles Adelsheim
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Patent number: 11529532Abstract: A radiation therapy system includes an accelerator and beam transport system that generates a beam of particles. The accelerator and beam transport system guides the beam on a path and into a nozzle that is operable for aiming the beam toward an object. The nozzle includes a scanning magnet operable for steering the beam toward different locations within the object, and also includes a beam energy adjuster configured to adjust the beam by, for example, placing different thicknesses of material in the path of the beam to affect the energies of the particles in the beam.Type: GrantFiled: February 22, 2021Date of Patent: December 20, 2022Assignee: Varian Medical Systems, Inc.Inventor: Stanley Mansfield
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Publication number: 20220008750Abstract: Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.Type: ApplicationFiled: September 27, 2021Publication date: January 13, 2022Applicant: VARIAN MEDICAL SYSTEMS, INC.Inventors: Renate PARRY, Eric ABEL, Swati GIRDHANI, Stanley MANSFIELD, Patrick KUPELIAN, Deepak KHUNTIA
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Patent number: 11173325Abstract: Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.Type: GrantFiled: July 20, 2018Date of Patent: November 16, 2021Assignee: Varian Medical Systems, Inc.Inventors: Renate Parry, Eric Abel, Swati Girdhani, Stanley Mansfield, Patrick Kupelian, Deepak Khuntia
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Publication number: 20210170202Abstract: A radiation therapy system includes an accelerator and beam transport system that generates a beam of particles. The accelerator and beam transport system guides the beam on a path and into a nozzle that is operable for aiming the beam toward an object. The nozzle includes a scanning magnet operable for steering the beam toward different locations within the object, and also includes a beam energy adjuster configured to adjust the beam by, for example, placing different thicknesses of material in the path of the beam to affect the energies of the particles in the beam.Type: ApplicationFiled: February 22, 2021Publication date: June 10, 2021Inventor: Stanley MANSFIELD
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Patent number: 10960231Abstract: A radiation therapy system includes an accelerator and beam transport system that generates a beam of particles. The accelerator and beam transport system guides the beam on a path and into a nozzle that is operable for aiming the beam toward an object. The nozzle includes a scanning magnet operable for steering the beam toward different locations within the object, and also includes a beam energy adjuster configured to adjust the beam by, for example, placing different thicknesses of material in the path of the beam to affect the energies of the particles in the beam.Type: GrantFiled: May 2, 2019Date of Patent: March 30, 2021Assignee: Varian Medical Systems, Inc.Inventor: Stanley Mansfield
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Publication number: 20210052917Abstract: Radiation treatment planning includes accessing values of parameters such as a number of beams to be directed into sub-volumes in a target, beam directions, and beam energies. Information that specifies limits for the radiation treatment plan are accessed. The limits include a limit on irradiation time for each sub-volume outside the target. Other limits can include a limit on irradiation time for each sub-volume in the target, a limit on dose rate for each sub-volume in the target, and a limit on dose rate for each sub-volume outside the target. The values of the parameters are adjusted until the irradiation time for each sub-volume outside the target satisfies the maximum limit on irradiation time.Type: ApplicationFiled: November 6, 2020Publication date: February 25, 2021Inventors: Reynald VANDERSTRAETEN, Eric ABEL, Christel SMITH, Anthony MAGLIARI, Timo KOPONEN, Stanley MANSFIELD, Charles ADELSHEIM
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Patent number: 10850124Abstract: Radiation treatment planning includes accessing values of parameters such as a number of beams to be directed into sub-volumes in a target, beam directions, and beam energies. Information that specifies limits for the radiation treatment plan are accessed. The limits include a limit on irradiation time for each sub-volume outside the target. Other limits can include a limit on irradiation time for each sub-volume in the target, a limit on dose rate for each sub-volume in the target, and a limit on dose rate for each sub-volume outside the target. The values of the parameters are adjusted until the irradiation time for each sub-volume outside the target satisfies the maximum limit on irradiation time.Type: GrantFiled: September 28, 2018Date of Patent: December 1, 2020Assignees: Varian Medical Systems International, AG, Varian Medical Systems, Inc.Inventors: Reynald Vanderstraeten, Eric Abel, Christel Smith, Anthony Magliari, Timo Koponen, Stanley Mansfield, Charles Adelsheim
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Patent number: 10441226Abstract: A radiation system includes a first ring, a radiation source capable of providing radiation suitable for treating a patient, the radiation source secured to the first ring, a second ring located behind the first ring, and an imager secured to the second ring. A radiation system includes a first device having a radiation source capable of generating a radiation beam suitable for treating a patient, and a second device having imaging capability, wherein the first device is oriented at an angle that is less than 180° relative to the second device. A radiation system includes a structure having a first opening, a radiation source rotatably coupled to the structure, an imaging device rotatable relative to the structure, and a processor for controlling a rotation of the radiation source and a rotation of the imaging device, wherein the radiation source is rotatable relative to the imaging device.Type: GrantFiled: March 23, 2017Date of Patent: October 15, 2019Assignee: Varian Medical Systems, Inc.Inventors: Timothy E. Guertin, Richard H. Stark, Raymond D. McIntyre, Steven W. Prince, Stanley Mansfield, George A. Zdasiuk
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Patent number: 10406382Abstract: A radiation system includes a radiation source providing therapeutic radiation, a first gantry supporting a second gantry carrying the radiation source. The first gantry is rotatable about a first axis passing through an isocenter, thereby allowing the radiation source to aim therapeutic radiation at a target volume from a plurality of locations in a first plane. The second gantry carrying the radiation source is rotatable about a second axis passing through the isocenter non-parallel with the first axis, thereby allowing the radiation source to aim therapeutic radiation at the target volume from a plurality of locations in a second plane non-coplanar with the first plane.Type: GrantFiled: April 21, 2017Date of Patent: September 10, 2019Assignee: Varian Medical Systems, Inc.Inventors: David Humber, Josh Star-Lack, Stanley Mansfield, Ross Hannibal
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Publication number: 20190255361Abstract: A radiation therapy system includes an accelerator and beam transport system that generates a beam of particles. The accelerator and beam transport system guides the beam on a path and into a nozzle that is operable for aiming the beam toward an object. The nozzle includes a scanning magnet operable for steering the beam toward different locations within the object, and also includes a beam energy adjuster configured to adjust the beam by, for example, placing different thicknesses of material in the path of the beam to affect the energies of the particles in the beam.Type: ApplicationFiled: May 2, 2019Publication date: August 22, 2019Inventor: Stanley MANSFIELD
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Patent number: 10307618Abstract: A radiation therapy system includes an accelerator and beam transport system that generates a beam of particles. The accelerator and beam transport system guides the beam on a path and into a nozzle that is operable for aiming the beam toward an object. The nozzle includes a scanning magnet operable for steering the beam toward different locations within the object, and also includes a beam energy adjuster configured to adjust the beam by, for example, placing different thicknesses of material in the path of the beam to affect the energies of the particles in the beam.Type: GrantFiled: December 21, 2017Date of Patent: June 4, 2019Assignee: Varian Medical Systems, Inc.Inventor: Stanley Mansfield
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Publication number: 20190060667Abstract: Radiation treatment planning includes accessing values of parameters such as a number of beams to be directed into sub-volumes in a target, beam directions, and beam energies. Information that specifies limits for the radiation treatment plan are accessed. The limits include a limit on irradiation time for each sub-volume outside the target. Other limits can include a limit on irradiation time for each sub-volume in the target, a limit on dose rate for each sub-volume in the target, and a limit on dose rate for each sub-volume outside the target. The values of the parameters are adjusted until the irradiation time for each sub-volume outside the target satisfies the maximum limit on irradiation time.Type: ApplicationFiled: September 28, 2018Publication date: February 28, 2019Inventors: Reynald VANDERSTRAETEN, Eric ABEL, Christel SMITH, Anthony MAGLIARI, Timo KOPONEN, Stanley MANSFIELD, Charles ADELSHEIM
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Patent number: 10188356Abstract: A radiation system includes a first ring, a radiation source capable of providing radiation suitable for treating a patient, the radiation source secured to the first ring, a second ring located behind the first ring, and an imager secured to the second ring. A radiation system includes a first device having a radiation source capable of generating a radiation beam suitable for treating a patient, and a second device having imaging capability, wherein the first device is oriented at an angle that is less than 180° relative to the second device. A radiation system includes a structure having a first opening, a radiation source rotatably coupled to the structure, an imaging device rotatable relative to the structure, and a processor for controlling a rotation of the radiation source and a rotation of the imaging device, wherein the radiation source is rotatable relative to the imaging device.Type: GrantFiled: June 20, 2011Date of Patent: January 29, 2019Assignee: VARIAN MEDICAL SYSTEMS, INC.Inventors: Timothy E. Guertin, Richard H. Stark, Raymond D. McIntyre, Steven W. Prince, Stanley Mansfield, George A. Zdasiuk
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Publication number: 20190022411Abstract: Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.Type: ApplicationFiled: July 20, 2018Publication date: January 24, 2019Applicant: VARIAN MEDICAL SYSTEMS, INC.Inventors: Renate Parry, Eric Abel, Swati Girdhani, Stanley Mansfield, Patrick Kupelian, Depak Khuntia
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Publication number: 20180304098Abstract: A radiation system includes a radiation source providing therapeutic radiation, a first gantry supporting a second gantry carrying the radiation source. The first gantry is rotatable about a first axis passing through an isocenter, thereby allowing the radiation source to aim therapeutic radiation at a target volume from a plurality of locations in a first plane. The second gantry carrying the radiation source is rotatable about a second axis passing through the isocenter non-parallel with the first axis, thereby allowing the radiation source to aim therapeutic radiation at the target volume from a plurality of locations in a second plane non-coplanar with the first plane.Type: ApplicationFiled: April 21, 2017Publication date: October 25, 2018Inventors: David Humber, Josh Star-Lack, Stanley Mansfield, Ross Hannibal
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Patent number: 10092774Abstract: Radiation treatment planning includes accessing values of parameters such as a number of beams to be directed into sub-volumes in a target, beam directions, and beam energies. Information that specifies limits for the radiation treatment plan are accessed. The limits include a limit on irradiation time for each sub-volume outside the target. Other limits can include a limit on irradiation time for each sub-volume in the target, a limit on dose rate for each sub-volume in the target, and a limit on dose rate for each sub-volume outside the target. The values of the parameters are adjusted until the irradiation time for each sub-volume outside the target satisfies the maximum limit on irradiation time.Type: GrantFiled: July 21, 2017Date of Patent: October 9, 2018Assignees: Varian Medical Systems International, AG, Varian Medical Systems, Inc.Inventors: Reynald Vanderstraten, Eric Abel, Christel Smith, Anthony Magliari, Timo Koponen, Stanley Mansfield, Charles Adelsheim