Abstract: Compounds exhibiting antiviral activity and/or inhibition of viral replication against viruses, particularly those belonging to the picornavirus-like supercluster, including coronavirus having a formula: (I) where X comprises a cyclic moiety, R2 is a branched or unbranched alkyl, cycloalkyl, aryl, arylalkyl, alkenyl, alkynyl, amino acid side chain, bicyclic or tricyclic side chain, combinations, and substituted forms thereof, and Z is selected from the group consisting of C1-C6 hydroxyalkyl, aldehydes, alpha-ketoamides, and bisulfite salts, and in particular —CH2OH, —CHO, —CH(0H)S03?Na+, and -[0(C=0)Rw]S03?Na+.

Abstract: Compounds and treatment methods with compounds exhibiting antiviral activity and/or inhibition of viral replication against viruses, particularly those belonging to the picornavirus-like supercluster, including coronavirus having a formula: or a prodrug or pharmaceutically-acceptable salt thereof, where: each X comprises at least one cyclic moiety directly attached to the oxygen or connected via an alkyl linkage, where at least one of the linkage and/or the X moiety comprises a deuterium substitution; and Z is selected from the group consisting of aldehydes and bisulfite salts, or the ester or carbamate prodrugs thereof.

Abstract: A system and method reduces multipass signal degradation attributable to non-linear processing, namely quantization and dequantization. In one embodiment, a decoder decodes a predetermined unit of data utilizing a first quantization value. A quantization restrictor receives the first quantization value and generates a second quantization value having a restricted value wherein the second quantization value is equal to the first quantization value divided by a given integer. An encoder encodes the predetermined unit of data utilizing the second quantization value. A function unit can be provided for performing a predetermined pixel domain function on the predetermined unit of data between the decoding operation of the decoder and the encoding operation of the encoder. In this system, the decoder performs an inverse discrete cosine transform on the predetermined unit of data, and dequantizes the predetermined unit of data.

Abstract: A fuseholder and method for manufacturing thereof, the fuse holder having a cap and a molded body to receive a fuse. The fuse holder has a first contact located at one end of the body to engage one end of the fuse. A cylindrical second contact having opposed J-shaped slots is disposed near the other end of the body. Engaging the other end of the fuse is a connector having a pair of tabs receivable by the J-shaped slots to form a conductive bayonet connection between the connector and the second contact. Protrusions on the connector slidably engage the second contact to maintain conductive contact therebetween if the bayonet connection is broken. The fuse holder can be adapted by modifying the connector or by using an adaptor to accommodate shorter fuses. To manufacture the fuse holder, the first and second contacts are insert-molded into the body.