Abstract: The present disclosure provides fusion proteins with improved signaling properties. Disclosed embodiments include fusion proteins that comprise an extracellular antigen-binding domain, a transmembrane domain, and an intracellular component comprising one or more domain or motif from a CD3?, ?, or ? protein, and have improved signaling in response to antigen-binding, including of antigens with reduced, low, or intermediate levels of expression on a target cell, such as a solid tumor cell. Recombinant host cells expressing the fusion proteins are also provided, as well as compositions and methods comprising the same.

Abstract: A patron tracking system for tracking patron activity in a casino enterprise, wherein the casino enterprise comprises a home casino and one or more non-home casinos, the patron tracking system comprising: a home local casino management system at the home casino; one or more non-home casino management systems at the one or more non-home casinos; wherein the local casino management systems contain customer data related to patron activity; a message router for transmitting customer data between the home and non-home local casino management systems; and wherein certain customer data residing on the home local casino management system is not shared with the one or more non-home local casino management systems.