Patents by Inventor Stanley T. Crooke

Stanley T. Crooke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chimeric oligomeric compounds and their use in gene modulation
    Publication number: 20040147023
    Abstract: Oligomer compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capble of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes at least one nucleotide comprising a chimeric organic composition. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleotide comprising a chimeric organic composition.
    Type: Application
    Filed: November 4, 2003
    Publication date: July 29, 2004
    Inventors: Brenda F. Baker, Anne B. Eldrup, Muthiah Manoharan, Balkrishen Bhat, Richard H. Griffey, Eric E. Swayze, Stanley T. Crooke
  • Cross-linked oligomeric compounds and their use in gene modulation
    Publication number: 20040147470
    Abstract: The present invention provides modified oligomeric compounds that modulate gene expression via an RNA interference pathway. The oligomeric compounds of the invention include one or more cross-linkages that can improve nuclease resistance or modify or enhance the pharmacokinetic and phamacodynamic properties of the oligomeric compound.
    Type: Application
    Filed: November 4, 2003
    Publication date: July 29, 2004
    Inventors: Muthiah Manoharan, Brenda Baker, Anne Eldrup, Balkrishen Bhat, Richard H. Griffey, Eric E. Swayze, Thazha P. Prakash, Stanley T. Crooke
  • Efficient reduction of target RNA's by single-and double-stranded oligomeric compounds
    Publication number: 20040137471
    Abstract: The present invention provides, inter alia, methods of selecting a single-stranded oligomeric compounds for inhibiting RNA expression, methods of generating double-stranded oligomeric compounds, methods of identifying optimized double-stranded oligomeric compounds, methods of selecting optimized single-stranded oligomeric compounds, methods of selecting optimized double-stranded oligomeric compounds, methods of identifying multifunctional oligomeric compounds, methods for optimizing target region selection for modulation of RNA expression, methods of optimizing expression modulation of RNA, and the like. The present invention further provides oligomeric compounds, 8-80 nucleobases in length targeted to a target RNA, wherein said oligomeric compound hybridizes to said target RNA and inhibits RNA levels by at least 50% in both single-stranded and double-stranded forms, and multifunctional oligomeric compounds.
    Type: Application
    Filed: September 18, 2003
    Publication date: July 15, 2004
    Inventors: Timothy Vickers, Seongjoon Koo, C. Frank Bennett, Stanley T. Crooke, Nicholas M. Dean, Brenda F. Baker
  • Human RNase III and compositions and uses thereof
    Publication number: 20040126867
    Abstract: The present invention provides polynucleotides encoding human RNAse III and polypeptides encoded thereby. Methods of using said polynucleotides and polypeptides are also provided.
    Type: Application
    Filed: February 9, 2004
    Publication date: July 1, 2004
    Inventors: Stanley T. Crooke, HongJiang Wu
  • Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in food products and cosmetics thereby
    Publication number: 20040122598
    Abstract: The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.
    Type: Application
    Filed: December 18, 2002
    Publication date: June 24, 2004
    Inventors: David J. Ecker, Richard Griffey, Rangarajan Sampath, Steven Hofstadler, John McNeil, Stanley T. Crooke
  • Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in forensic studies thereby
    Publication number: 20040122857
    Abstract: The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further elates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.
    Type: Application
    Filed: December 18, 2002
    Publication date: June 24, 2004
    Inventors: David J. Ecker, Richard Griffey, Rangarajan Sampath, Steven Hofstadler, John McNeil, Stanley T. Crooke
  • Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent associated with host versus graft and graft versus host rejections thereby
    Publication number: 20040121340
    Abstract: The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.
    Type: Application
    Filed: December 18, 2002
    Publication date: June 24, 2004
    Inventors: David J. Ecker, Richard Griffey, Rangarajan Sampath, Steven Hofstadler, John McNeil, Stanley T. Crooke
  • Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in blood, bodily fluids, and bodily tissues thereby
    Publication number: 20040121329
    Abstract: The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.
    Type: Application
    Filed: December 18, 2002
    Publication date: June 24, 2004
    Inventors: David J. Ecker, Richard Griffey, Rangarajan Sampath, Steven Hofstadler, John McNeil, Stanley T. Crooke
  • Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in containers thereby
    Publication number: 20040121315
    Abstract: The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.
    Type: Application
    Filed: December 18, 2002
    Publication date: June 24, 2004
    Inventors: David J. Ecker, Richard Griffey, Rangarajan Sampath, Steven Hofstadler, John McNeil, Stanley T. Crooke
  • Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent thereby
    Publication number: 20040117129
    Abstract: The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.
    Type: Application
    Filed: May 16, 2003
    Publication date: June 17, 2004
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke
  • Human RNase H1 and oligonucleotide compositions thereof
    Publication number: 20040102618
    Abstract: The present invention provides oligonucleotides that can serve as substrates for human Type 2 RNase H. The present invention is also directed to methods of using these oligonucleotides in enhancing antisense oligonucleotide therapies.
    Type: Application
    Filed: July 8, 2003
    Publication date: May 27, 2004
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Stanley T. Crooke, Walter F. Lima, Hongjiang Wu
  • Human RNase III and compositions and uses thereof
    Patent number: 6737512
    Abstract: The present invention provides polynucleotides encoding human RNAse III and polypeptides encoded thereby. Methods of using said polynucleotides and polypeptides are also provided.
    Type: Grant
    Filed: July 6, 2001
    Date of Patent: May 18, 2004
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Hongjiang Wu, Stanley T. Crooke
  • Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent for environmental testing thereby
    Publication number: 20030225529
    Abstract: The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.
    Type: Application
    Filed: December 18, 2002
    Publication date: December 4, 2003
    Inventors: David J. Ecker, Richard Griffey, Rangarajan Sampath, Steven Hofstadler, John McNeil, Stanley T. Crooke
  • Mass spectrometric methods for biomolecular screening
    Patent number: 6656690
    Abstract: The present invention provides methods for the determination of the structure of biomolecular targets, as well as the site and nature of the interaction between ligands and biomolecular targets. The present invention also provides methods for the determination of the relative affinity of a ligand for the biomolecular target it interacts with. Also provided are methods for screening ligand or combinatorial libraries of compounds against one or more than one biological target molecules. The methods of the invention also allow determination of the relative binding affinity of combinatorial and other compounds for a biomolecular target. The present invention further provides methods for the use of mass modifying tags for screening multiple biomolecular targets. In a preferred embodiment, ligands which have great specificity and affinity for molecular interaction sites on biomolecules, especially RNA can be identified.
    Type: Grant
    Filed: June 19, 2001
    Date of Patent: December 2, 2003
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Stanley T. Crooke, Richard Griffey, Steven Hofstadler
  • Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent thereby
    Publication number: 20030187593
    Abstract: The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.
    Type: Application
    Filed: January 10, 2003
    Publication date: October 2, 2003
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven Hofstadler, John McNeil, Stanley T. Crooke
  • Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent thereby
    Publication number: 20030187588
    Abstract: The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.
    Type: Application
    Filed: January 10, 2003
    Publication date: October 2, 2003
    Inventors: David J. Ecker, Richard Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke
  • Human Rnase H1 and oligonucleotide compositions thereof
    Patent number: 6617442
    Abstract: The present invention provides oligonucleotides that can serve as substrates for human Type 2 RNase H. The present invention is also directed to methods of using these oligonucleotides in enhancing antisense oligonucleotide therapies.
    Type: Grant
    Filed: September 30, 1999
    Date of Patent: September 9, 2003
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Stanley T. Crooke, Walter F. Lima, Hongjiang Wu, Muthiah Monoharan
  • Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent thereby
    Publication number: 20030167133
    Abstract: The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.
    Type: Application
    Filed: January 10, 2003
    Publication date: September 4, 2003
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke
  • Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent thereby
    Publication number: 20030167134
    Abstract: The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.
    Type: Application
    Filed: January 10, 2003
    Publication date: September 4, 2003
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke
  • Human RNase H and compositions and uses thereof
    Publication number: 20030144496
    Abstract: The present invention provides polynucleotides and polypeptides encoded thereby of human Type 2 RNase H. Methods of using these polynucleotides and polypeptides in enhancing antisense oligonucleotide therapies are also provided.
    Type: Application
    Filed: February 3, 2003
    Publication date: July 31, 2003
    Inventors: Stanley T. Crooke, Walter Lima, Hongjiang Wu