Patents by Inventor Stanley W. Walinsky
Stanley W. Walinsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6608195Abstract: The present invention relates to a novel process for the preparation of a compound of formula I: wherein R1 is defined herein and compounds of formula II: wherein R1 and R2 are defined herein. Said compound of formula I is useful in the treatment of various central nervous system disorders including depression.Type: GrantFiled: August 29, 2002Date of Patent: August 19, 2003Assignee: Pfizer Inc.Inventors: Joseph P. Rainville, Terry G. Sinay, Stanley W. Walinsky
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Publication number: 20030087914Abstract: The present invention relates to a novel process for the preparation of a compound of formula I: 1Type: ApplicationFiled: August 29, 2002Publication date: May 8, 2003Applicant: Pfizer Inc.Inventors: Joseph P. Rainville, Terry G. Sinay, Stanley W. Walinsky
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Patent number: 6111105Abstract: The present invention relates to processes for the preparation of 3-(1-piperazinyl)-1,2-benzoisothiazole or its pharmaceutically acceptable salt and to novel intermediates used in the process.Type: GrantFiled: October 15, 1998Date of Patent: August 29, 2000Assignee: Pfizer, Inc.Inventors: Darrell E. Fox, John F. Lambert, Terry G. Sinay, Stanley W. Walinsky
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Patent number: 5935960Abstract: The present invention relates to a pro-drug of ziprasidone or pharmaceutically acceptable salts thereof, processes for its preparation, and pharmaceutical compositions and methods of treatment comprising said pro-drug.Type: GrantFiled: February 7, 1997Date of Patent: August 10, 1999Assignee: Pfizer Inc.Inventors: Stanley W. Walinsky, John F. Lambert
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Patent number: 5606041Abstract: Processes for the synthesis of tigogenin beta-O-cellobioside heptaalkanoate which is an intermediate for the known hypo-cholesterolemic agent tigogenin beta-cellobioside. The process comprises reacting .alpha.-cellobiosyl bromide heptaalkanoate and .beta.-tigogenin in the presence of zinc fluoride or zinc cyanide under conditions capable of forming said tigogenyl .beta.-O-cellobioside heptaalkanoate. The analogous preparations of hecogenin .beta.-O-cellobioside heptaalkanoate 11-ketotigogenin .beta.-O-cellobioside heptaalkanoate, and diosgenin .beta.-O-cellobioside heptaalkanoate are also disclosed. The process provides both high .beta.-anomeric selectivity and high yields.Type: GrantFiled: December 20, 1994Date of Patent: February 25, 1997Assignee: Pfizer Inc.Inventors: Frank R. Busch, Kathleen D. Goggin, John F. Lambert, Russell J. Shine, Stanley W. Walinsky
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Patent number: 5563259Abstract: A process for the synthesis of peracyl-1-O-steroidal-.beta.-cellobiosides that provides excellent .beta.-anomeric selectivity without the use of a metal salt promoter. The process comprises reacting heptaacyl-.beta.-D-cellobiosyl-1-fluoride and a trisubstituted silyl-3-O-steroid, wherein the steroid is tigogenin, hecogenin, 11-ketotigogenin or diosgenin in the absence of a metal salt under suitable conditions.Type: GrantFiled: December 20, 1994Date of Patent: October 8, 1996Assignee: Pfizer Inc.Inventors: Kathleen D. Goggin, John F. Lambert, Stanley W. Walinsky
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Patent number: 5530107Abstract: Processes for the synthesis of tigogenin beta-O-cellobioside heptaalkanoate which is an intermediate for the known hypocholesterolemic agent tigogenin beta-cellobioside. The process comprises reacting .alpha.-cellobiosyl bromide heptaalkanoate and .beta.-tigogenin in the presence of zinc fluoride or zinc cyanide under conditions capable of forming said tigogenyl .beta.-O-cellobioside heptaalkanoate. The analogous preparations of hecogenin .beta.-O-cellobioside heptaalkanoate, 11-ketotigogenin .beta.-O-cellobioside heptaalkanoate, and diosgenin .beta.-O-cellobioside heptaalkanoate are also disclosed. The process provides both high .beta.-anomeric selectivity and high yields.Type: GrantFiled: May 23, 1994Date of Patent: June 25, 1996Assignee: Pfizer Inc.Inventors: Douglas J. M. Allan, Frank R. Busch, John F. Lambert, Russell J. Shine, Stanley W. Walinsky
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Patent number: 5032646Abstract: Substantially homogeneous (meth)acrylic acid/itaconic acid copolymers of number average molecular weight of 500 to 7000 are prepared by copolymerizing in aqueous solution 5 to 90 mole percent acrylic or methacrylic acid monomer with 95 to 10 mole percent itaconic acid monomer at 80.degree. to 120.degree. C. in the presence of a polymerization initiator, the acrylic or methacrylic acid monomer and at least half of the initiator being added separately and continuously to the itaconic acid monomer throughout the polymerization period. The copolymers are employed at a level of from about 0.1 to 100 ppm for prevention of alkaline calcium and magnesium scale formation, such as during seawater evaporative desalination.Type: GrantFiled: September 28, 1984Date of Patent: July 16, 1991Assignee: Pfizer Inc.Inventor: Stanley W. Walinsky
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Patent number: 4997981Abstract: An amine substituion process for 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole, for precursor N-(pentylamidino)thiourea, and for analogs thereof of said compounds.Type: GrantFiled: April 20, 1989Date of Patent: March 5, 1991Assignee: Pfizer Inc.Inventors: Paul D. Hill, William M. Snyder, Stanley W. Walinsky
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Patent number: 4710537Abstract: Substantially homogeneous acrylate/maleate copolymers of number average molecular weight of 500 to 5000 are prepared by copolymerizing 35 to 65 mole percent acrylic or methacrylic acid with 65 to 35 mole percent maleic anhydride at 80.degree. to 150.degree. C. in the presence of a polymerization initiator and a chain-transfer solvent such that both the monomers and the formed polymer remain in solution and the mole ratio of the acrylic or methacrylic acid monomer to the maleic anhydride monomer in the solvent is maintained below about 0.2 throughout the polymerization. The copolymers in hydrolyzed form are employed at a level of from about 0.1 to 100 ppm for prevention of alkaline calcium and magnesium scale formation, such as during seawater evaporative desalination.Type: GrantFiled: October 11, 1985Date of Patent: December 1, 1987Assignee: Pfizer Inc.Inventor: Stanley W. Walinsky
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Patent number: 4602067Abstract: An aqueous drilling fluid suitable for high-temperature use comprising a water base, clay suspended in said base and from about 0.01-25 pounds per barrel total composition of a hydrolyzed terpolymer of maleic anhydride, styrene and a third monomer selected from acrylamide, methacrylamide, acrylic acid or methacrylic acid, the molar ratio of maleic anhydride to styrene to said third monomer being from about 30:10:60 to 50:40:10, and the alkali metal, ammonium and lower aliphatic amine salts thereof, the weight-average molecular weight of said hydrolyzed terpolymer being from about 500-10,000. An improved drilling process wherein such fluids remain flowable at elevated temperatures is also disclosed.Type: GrantFiled: March 28, 1985Date of Patent: July 22, 1986Assignee: Pfizer Inc.Inventors: Randel E. Stong, Stanley W. Walinsky
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Patent number: 4566978Abstract: An aqueous drilling fluid suitable for high-temperature use comprising a water base, clay suspended in said base and from about 0.01-25 pounds per barrel total composition of a hydrolyzed terpolymer of maleic anhydride, styrene and a third monomer selected from acrylamide, methacrylamide, acrylic acid or methacrylic acid, the molar ratio of maleic anhydride to styrene to said third monomer being from about 30:10:60 to 50:40:10, and the alkali metal, ammonium and lower aliphatic amine salts thereof, the weight-average molecular weight of said hydrolyzed terpolymer being from about 500-10,000. An improved drilling process wherein such fluids remain flowable at elevated temperatures is also disclosed.Type: GrantFiled: May 21, 1984Date of Patent: January 28, 1986Assignee: Pfizer Inc.Inventors: Randel E. Stong, Stanley W. Walinsky
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Patent number: 4547559Abstract: Substantially homogeneous acrylate/maleate copolymers of number average molecular weight of 500 to 5000 are prepared by copolymerizing 35 to 65 mole percent acrylic or methacrylic acid with 65 to 35 mole percent maleic anhydride at 80.degree. to 150.degree. C. in the presence of a polymerization initiator and a chain-transfer solvent such that both the monomers and the formed polymer remain in solution and the mole ratio of the acrylic or methacrylic acid monomer to the maleic anhydride monomer in the solvent is maintained below about 0.2 throughout the polymerization. The copolymers in hydrolyzed form are employed at a level of from about 0.1 to 100 ppm for prevention of alkaline calcium and magnesium scale formation, such as during seawater evaporative desalination.Type: GrantFiled: March 18, 1983Date of Patent: October 15, 1985Assignee: Pfizer Inc.Inventor: Stanley W. Walinsky
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Patent number: 4533709Abstract: Fumaric acid polymers may be used to control or inhibit scaling in boilers, desalination plants, steam generators, cooling equipment and the like. A novel process for their synthesis employs a mono or dialkyl ester of fumaric acid as a starting material.Type: GrantFiled: September 28, 1984Date of Patent: August 6, 1985Assignee: Pfizer Inc.Inventor: Stanley W. Walinsky
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Patent number: 4486581Abstract: Pumaric acid polymers may be used to control or inhibit scaling in boilers, desalination plants, steam generators, cooling equipment and the like. A novel process for their synthesis employs a mono or dialkyl ester of fumaric acid as a starting material.Type: GrantFiled: November 12, 1982Date of Patent: December 4, 1984Assignee: Pfizer Inc.Inventor: Stanley W. Walinsky
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Patent number: 4485223Abstract: Substantially homogeneous (meth)acrylic acid/itaconic acid copolymers of number average molecular weight of 500 to 7000 are prepared by copolymerizing in aqueous solution 5 to 90 mole percent acrylic or methacrylic acid monomer with 95 to 10 mole percent itaconic acid monomer at 80.degree. to 120.degree. C. in the presence of a polymerization initiator, the acrylic or methacrylic acid monomer and at least half of the initiator being added separately and continuously to the itaconic acid monomer throughout the polymerization period. The copolymers are employed at a level of from about 0.1 to 100 ppm for prevention of alkaline calcium and magnesium scale formation, such as during seawater evaporative desalination.Type: GrantFiled: July 22, 1982Date of Patent: November 27, 1984Assignee: Pfizer Inc.Inventor: Stanley W. Walinsky
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Patent number: 4390670Abstract: Substantially homogeneous acrylate/maleate copolymers of number average molecular weight of 500 to 5000 are prepared by copolymerizing 35 to 65 mole percent acrylic or methacrylic acid with 65 to 35 mole percent maleic anhydride at 80.degree. to 150.degree. C. in the presence of a polymerization initiator and a chain-transfer solvent such that both the monomers and the formed polymer remain in solution and the mole ratio of the acrylic or methacrylic acid monomer to the maleic anhydride monomer in the solvent is maintained below about 0.2 throughout the polymerization. The copolymers in hydrolyzed form are employed at a level of from about 0.1 to 100 ppm for prevention of alkaline calcium and magnesium scale formation, such as during seawater evaporative desalination.Type: GrantFiled: February 9, 1981Date of Patent: June 28, 1983Assignee: Pfizer Inc.Inventor: Stanley W. Walinsky