Abstract: A method and system are disclosed for enabling design of a product such as a colored plastic having a visual effect caused by an additive. In one embodiment, a user such as a designer at a first computing unit is able to interact with a second computing unit operable to provide a generally accurate representation of the product having the visual effect. Desirably, the user inputs information relating to the additive such as a flake material or a diffuser material and the system provides a representation displayable on a display or monitor of the first computing unit of the product having the visual effect based on the information relating to the additive. The design of the product having the visual effect is advantageously stored on the second computing unit and accessible by at least one second user such as a marketer or manufacturer for review of the design.

Abstract: A cell-based binning method (“Data Driven” binning method) allows the inclusion of all molecules, generates a high percentage of occupied cells, and provides adequate division of the molecules in the low-dimensional subspaces (typically all one-dimension (1-D), two-dimension (2-D), and three-dimension (3-D) subspaces). A chemical space coverage criterion (“Uniform Cell Coverage (UCC)” criterion) measures the uniformity of coverage of the molecules selected. A fast exchange design algorithm (“fast exchange UCC” algorithm) that minimizes the number of searches of the candidate points while maximizing the number of exchanges during each pass through the candidate points. This method is many times faster than previous exchange algorithms and generates designs with good coverage properties.

Abstract: Embodiments of this invention comprise a pigment comprising one or more substantially spherical-shaped beads, wherein each substantially spherical-shaped bead comprises one or more high aspect ratio particles encapsulated within an encapsulating material. Embodiments also comprise a resinous composition comprising said pigment. Yet further embodiments comprise a method of preparing said pigment via suspension polymerization. The substantially spherical-shaped beads of this invention may be used to produce resinous compositions having a flowline-free colored, sparkling and/or metallescent appearance.

Abstract: A method of drug discovery in finding compounds with some desired activity for a chosen biological target that reduces reliance on searches of relatively large numbers of compounds. Rules are derived from a relatively small screening data set linking structural features to biological activity, which rules can be used to guide the selection of additional compounds for screening so that screening costs can be reduced as the total number of compounds screened is reduced. Properties of compounds are described numerically and said compounds are placed into small mathematical bins that comprise narrow ranges of the numerical descriptors. Through statistical analysis, it is then determined which combinations of bins describe regions of chemical space that are most likely to contain active compounds. Untested compounds that fall into these regions are then seen as good candidates for screening.

Abstract: A client-server authentication method for use where a server process has access to a repository storing cipher-protected client passwords. The method includes applying the same cipher function to the client's copy of its password as was previously applied to generate the stored cipher-protected client passwords. This ensures that both the client and server have access to an equivalent cipher-protected client password—providing a shared secret for driving a mutual challenge-response authentication protocol without having to convert the password into cleartext at the server. The invention can be implemented without significant additional software infrastructure in a UNIX environment. Client passwords are typically stored in the UNIX password repository under the protection of the crypt( ) function applied to the combination of the password and a random number (a ‘salt’).

Abstract: Statistical classification of activities of molecules is a computer implemented methodology of QSAR employing visualization of molecular features and statistical techniques for correlating features of molecules with their observed biological properties. Each molecule is described by noting the presence (1) or absence (0) of a feature of interest. The identification of specific features coded by 1's or 0's is accomplished by recursive partitioning. The data sets are planned or unplanned. The method is also applicable to classification of individuals in biological populations on the basis of their genetic makeup.

Abstract: Thread-based methods and systems for using the idle processing power of one or more networked computers include at least one server and at least one client. The server stores data and job descriptions relating to a complex scientific problem and provides the job descriptions and portions of the data to clients in response to requests from the clients. Each of the clients starts a first idle thread for pulling job descriptions from the server. Each client also starts a second idle thread for requesting data from the server and for performing the job specified in the job description. The first and second idle threads are automatically scheduled for execution by the operating system.

Abstract: A method and apparatus for display of access control in a graphical user interface (100) is provided including displaying resources in a tree structure (102) having a plurality of nodes (104, 114, 120. . . ). Each node represents a resource and each resource has the potential for one or more users in relation to one or more actions on the resource. Permission to perform an action on a resource by a principal can be selectively displayed (134). The principal can be an individual user or a group of users. The result of a query relating to permission to perform an action on a specified resource for a principal (182) can be displayed on the tree structure (102).

Abstract: Conditional associations among features in samples are identified by defining a matrix having rows that represent the samples and columns that represent the features. Each row-column position of the matrix has a first binary value if the sample that is associated with the row exhibits the feature that is associated with the column, and a second binary value if a sample that is associated with the row does not exhibit the feature that is associated with the column. Recursive partitioning then is performed for each column. In particular, for each column, the column is recursively partitioned relative to the remaining ones of the columns, to define a tree of conditional branches for the rows for each column. The collection of trees of conditional branches for the columns may be displayed and/or analyzed to identify conditional associations of interest. Continuous features, wherein each row-column position of the matrix has a value selected from a continuous range of values, also may be analyzed.

Abstract: Statistical classification of activities of molecules is a computer implemented methodology of QSAR employing visualization of molecular features and statistical techniques for correlating features of molecules with their observed biological properties. Each molecule is described by noting the presence (1) or absence (0) of a feature of interest. The identification of specific features coded by 1's or 0's is accomplished by recursive partitioning. The data sets are planned or unplanned. The method is also applicable to classification of individuals in biological populations on the basis of their genetic makeup.

Abstract: The present invention refers to a method of forming cables whether or not all metallic, flexible armored tubes, armored electrical conductors and the like which consists of applying heat to the wires which will form the armor before they are placed around the core and in some cases to all the subsequent layers of a cable having a multiplicity of layers.