Patents by Inventor Stanton Gerson

Stanton Gerson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY
    Publication number: 20240043443
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
    Type: Application
    Filed: July 31, 2023
    Publication date: February 8, 2024
    Inventors: Sanford Markowitz, James K.V. Willson, Bruce Posner, Joseph Ready, Yongyou Zhang, Hsin-Hsiung Tai, Monica Antczak, Stanton Gerson, KiBeom Bae, Sung Yeun Yang, Amar Desai
  • Compositions and Methods of Modulating Short-Chain Dehydrogenase Activity
    Publication number: 20230285402
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: March 3, 2023
    Publication date: September 14, 2023
    Inventors: Sanford Markowitz, James K. V. Willson, Bruce Posner, Joseph Ready, Monika Antczak, Yongyou Zhang, Amar Desai, Stanton Gerson, William Greenlee, Sung Yeun Yang, KiBeom Bae
  • COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
    Publication number: 20230192717
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: May 19, 2021
    Publication date: June 22, 2023
    Inventors: Stephen L Gwaltney, Joseph Ready, Monika Antczak, Sanford Markowitz, Amar Desai, Stanton Gerson
  • COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
    Publication number: 20230136730
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: August 2, 2022
    Publication date: May 4, 2023
    Inventors: Sanford Markowitz, James K.V. Willson, Bruce Posner, Joseph Ready, Monika Antczak, Yongyou Zhang, Amar Desai, Stanton Gerson, William Greenlee, Sung Yeun Yang, KiBeom Bae
  • INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR TREATING FIBROSIS
    Publication number: 20210283113
    Abstract: A method of treating or preventing a fibrotic disease, disorder or condition includes administering to a subject in need of treatment a 15-PGDH inhibitor.
    Type: Application
    Filed: December 23, 2020
    Publication date: September 16, 2021
    Inventors: Sanford Markowitz, Stanton Gerson, Amar Desai, Won Jin Ho
  • COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY
    Publication number: 20210106587
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: August 19, 2020
    Publication date: April 15, 2021
    Inventors: Sanford Markowitz, James K.V. Willson, Bruce Posner, Joseph Ready, Monika Antczak, Yongyou Zhang, Amar Desai, Stanton Gerson, William Greenlee, Sung Yeun Yang, KiBeom Bae
  • Inhibitors of short-chain dehydrogenase activity for treating fibrosis
    Patent number: 10945998
    Abstract: A method of treating or preventing a fibrotic disease, disorder or condition includes administering to a subject in need of treatment a 15-PGDH inhibitor.
    Type: Grant
    Filed: March 8, 2016
    Date of Patent: March 16, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Sanford Markowitz, Stanton Gerson, Amar Desai, Won Jin Ho
  • COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY
    Publication number: 20210032265
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
    Type: Application
    Filed: July 30, 2020
    Publication date: February 4, 2021
    Inventors: Sanford Markowitz, James K.V. Willson, Bruce Posner, Joseph Ready, Yongyou Zhang, Hsin-Hsiung Tai, Monika Antczak, Stanton Gerson, KiBeom Bae, Sung Yeun Yang, Amar Desai
  • Compositions and methods of modulating short-chain dehydrogenase activity
    Patent number: 10869871
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: December 22, 2020
    Assignees: CASE WESTERN RESERVE UNIVERSITY, THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Sanford Markowitz, James K.V. Wilson, Bruce Posner, Joseph Ready, Monika Antczak, Yongyou Zhang, Amar Desai, Stanton Gerson, William Greenlee, Sung Yeun Yang, KiBeom Bae
  • Methods of diagnosing and treating cancer
    Patent number: 10722530
    Abstract: A method of treating cancer in a subject includes determining the p53 status and the level of UDG in cancer cells of the subject and administering an antimetabolite agent in combination with an AP endonuclease inhibitor or UDG inhibitor if the determined level of UDG in the cancer cells is increased relative to the control level and the cancer cells are p53 mutant or deficient cancer cells.
    Type: Grant
    Filed: December 26, 2017
    Date of Patent: July 28, 2020
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Stanton Gerson, Yan Yan
  • Methods of diagnosing and treating cancer
    Patent number: 10725042
    Abstract: A method of determining the susceptibility of a cancer in a subject to treatment with an antimetabolite includes obtaining a sample of cancer cells from the subject, measuring the level of UDG expression in the cancer cells, and comparing the measured levels of UDG expression in the cancer cells to a control level.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: July 28, 2020
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventor: Stanton Gerson
  • COMPOSITIONS AND METHODS OF MODULATING 15-PGDH ACTIVITY
    Publication number: 20200140453
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
    Type: Application
    Filed: May 24, 2019
    Publication date: May 7, 2020
    Inventors: Sanford Markowitz, James K.V. Willson, Bruce Posner, Joseph Ready, Youngyou Zhang, Hsin-Hsiung Tai, Monika Antczak, Stanton Gerson, KiBeom Bae, Sung Yeun Yang, Amar Desai
  • COMPOSITIONS AND METHODS OF MODULATING SHIRT-CHAIN DEHYDROGENASE ACTIVITY
    Publication number: 20190365769
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Application
    Filed: October 16, 2017
    Publication date: December 5, 2019
    Inventors: Sanford Markowitz, James K.V. Willson, Bruce Posner, Joseph Ready, Monika Antczak, Yongyou Zhang, Amar Desai, Stanton Gerson, William Greenlee, Sung Yeun Yang, KiBeom Bae
  • Compositions and methods of modulating 15-PGDH activity
    Patent number: 10301320
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: May 28, 2019
    Assignees: University of Kentucky Research Foundation, Case Western Reserve University, Board of Regents of the University of Texas System
    Inventors: Sanford Markowitz, James K. V. Willson, Bruce Posner, Joseph Ready, Youngyou Zhang, Hsin-Hsiung Tai, Monika Antczak, Stanton Gerson, KiBeom Bae, Sung Yeun Yang, Amar Desai
  • METHODS OF DIAGNOSING AND TREATING CANCER
    Publication number: 20180185403
    Abstract: A method of treating cancer in a subject includes determining the p53 status and the level of UDG in cancer cells of the subject and administering an antimetabolite agent in combination with an AP endonuclease inhibitor or UDG inhibitor if the determined level of UDG in the cancer cells is increased relative to the control level and the cancer cells are p53 mutant or deficient cancer cells.
    Type: Application
    Filed: December 26, 2017
    Publication date: July 5, 2018
    Inventors: Stanton Gerson, Yan Yan
  • FLUORESCENT PROBES FOR ABASIC SITE DETECTION
    Publication number: 20180127830
    Abstract: A fluorescent probe for binding to and detection of AP sites of DNA includes the following formula: F-L-X where F is a fluorescent moiety, X is an aminooxy group (—ONH2), and L is a linker that links or couples the fluorescent moiety to the oxyamine.
    Type: Application
    Filed: April 14, 2016
    Publication date: May 10, 2018
    Inventors: Stanton Gerson, Yanming Wang, Allison G. Condit
  • INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR TREATING FIBROSIS
    Publication number: 20180064694
    Abstract: A method of treating or preventing a fibrotic disease, disorder or condition includes administering to a subject in need of treatment a 15-PGDH inhibitor.
    Type: Application
    Filed: March 8, 2016
    Publication date: March 8, 2018
    Inventors: Sanford Markowitz, Stanton Gerson, Amar Desai, Won Jin Ho
  • Inhibitors of short-chain dehydrogenase activity for modulating hematopoietic stem cells and hematopoiesis
    Patent number: 9801863
    Abstract: A method of modulating hematopoietic stem cells and hematopoiesis includes administering to a subject in need thereof a 15-PGDH inhibitor.
    Type: Grant
    Filed: November 9, 2016
    Date of Patent: October 31, 2017
    Assignees: Case Western Reserve University, Board of Regents of the Univeristy of Texas System
    Inventors: Sanford Markowitz, Amar Desai, Stanton Gerson, Joseph Ready
  • Compositions and methods of modulating short-chain dehydrogenase activity
    Patent number: 9789116
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: October 17, 2017
    Assignees: Case Western Reserve University, Board of Regents of the University of Texas System
    Inventors: Sanford Markowitz, James K. V. Willson, Bruce Posner, Joseph Ready, Monika Antczak, Yongyou Zhang, Amar Desai, Stanton Gerson, William Greenlee
  • Compositions and methods of modulating 15-PGDH activity
    Patent number: 9790233
    Abstract: Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
    Type: Grant
    Filed: April 16, 2013
    Date of Patent: October 17, 2017
    Assignees: Case Western Reserve University, Board of Regents of the University of Texas System, University of Kentucky Research Foundation
    Inventors: Sanford Markowitz, James K. V. Willson, Bruce A. Posner, Joseph Ready, Yongyou Zhang, Hsin-Hsiung Tai, Monika Antczak, Stanton Gerson, KiBeom Bae, Sung Yeun Yang, Amar Desai