Patents by Inventor Stanton Hon Lung Kok

Stanton Hon Lung Kok has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of using an indolinone molecule and derivatives for inhibiting liver fibrosis and hepatitis
    Patent number: 10450295
    Abstract: This invention relates to methods of reversing and inhibiting liver fibrosis and hepatitis using a small indolinone molecule Hesperadin and related compounds. Methods of identifying such agents and using them to inhibit the expression of collagens and ECM proteins including MMPs and TIMPs in purified hepatic stellate cells are provided. In vivo data of Hesperadin in inhibiting induced collagen production are presented. This method of specifically targeting drugs to hepatic stellate cells in vivo, provides a novel therapy for liver diseases.
    Type: Grant
    Filed: August 9, 2013
    Date of Patent: October 22, 2019
    Assignee: Acclaim BioMed USA LLC
    Inventors: Kenneth Ka-Ho Lee, Stanton Hon-Lung Kok, Tsz-Wai Kok, Sing-Wan Wong, John Yeuk-Hon Chan
  • Method of making and administering quinoline derivatives as anti-cancer agents
    Patent number: 9321730
    Abstract: The present invention relates methods of preparing quinoline derivative compounds, and administering such compounds in the treatment of solid and non-solid tumors, notably on liver cancer.
    Type: Grant
    Filed: August 21, 2007
    Date of Patent: April 26, 2016
    Assignee: The Hong Kong Polytechnic University
    Inventors: Albert Sun-chi Chan, Johnny Cheuk-on Tang, Kim-hung Lam, Chung-hin Chui, Stanton Hon-lung Kok, Sau Hing Chan, Filly Cheung, Roberto Gambari, Chor Hing Cheng
  • METHOD OF USING AN INDOLINONE MOLECULE AND DERIVATIVES FOR INHIBITING LIVER FIBROSIS AND HEPATITIS
    Publication number: 20150045395
    Abstract: This invention relates to methods of reversing and inhibiting liver fibrosis and hepatitis using a small indolinone molecule Hesperadin and related compounds. Methods of identifying such agents and using them to inhibit the expression of collagens and ECM proteins including MMPs and TIMPs in purified hepatic stellate cells are provided. In vivo data of Hesperadin in inhibiting induced collagen production are presented. This method of specifically targeting drugs to hepatic stellate cells in vivo, provides a novel therapy for liver diseases.
    Type: Application
    Filed: August 9, 2013
    Publication date: February 12, 2015
    Applicant: Acclaim BioMed USA LLC
    Inventors: Kenneth Ka-Ho Lee, Stanton Hon-Lung Kok, Tsz-Wai Kok, Sing-Wan Wong, John Yeuk-Hon Chan
  • Water-soluble polymer-based cantharimides as potentially selective anti-tumor agents
    Patent number: 8344007
    Abstract: A cantharimide compound may include the backbone of formula (1). R1, R2, R3, and R4 may be independently selected from the group consisting of H, C(O)OR5, C(O)R6, C(O)NR7R8, NR9C(O)R10, N—R11R12, O—R13, S—R14, P(O)(OR15)(OR16), As(O)(OR17)(OR18), SO2R19, SO3R20, and B(OR21). X1 to X4 may be independently selected from the group consisting of nitrogen and carbon, such that X1 to X4 are not all hydrogen. Y1, Y2 and R5 to R21 may be independently selected from the group consisting of hydrogen, C1-12-alkyl, -aryl, heteroaryl, and a bioactive polymer.
    Type: Grant
    Filed: April 23, 2009
    Date of Patent: January 1, 2013
    Assignee: The Hong Kong Polytechnic University
    Inventors: Johnny Cheuk-on Tang, Albert Sun-chi Chan, Kim-hung Lam, Chung-hin Chui, Stanton Hon Lung Kok, Marcus Chun Wah Yuen, Sau Hing Chan, Chor Hing Cheng, Filly Cheung
  • WATER-SOLUBLE POLYMER-BASED CANTHARIMIDES AS POTENTIALLY SELECTIVE ANTI-TUMOR AGENTS
    Publication number: 20100273840
    Abstract: A cantharimide compound may include the backbone of formula (1). R1, R2, R3, and R4 may be independently selected from the group consisting of H, C(O)OR5, C(O)R6, C(O)NR7R8, NR9C(O)R10, N—R11R12, O—R13, S—R14, P(O)(OR15)(OR16), As(O)(OR17)(OR18), SO2R19, SO3R20, and B(OR21). X1 to X4 may be independently selected from the group consisting of nitrogen and carbon, such that X1 to X4 are not all hydrogen. Y1, Y2 and R5 to R21 may be independently selected from the group consisting of hydrogen, C1-12-alkyl, -aryl, heteroaryl, and a bioactive polymer.
    Type: Application
    Filed: April 23, 2009
    Publication date: October 28, 2010
    Inventors: Johnny Cheuk-on Tang, Albert Sun-chi Chan, Kim-hung Lam, Chung-hin Chui, Stanton Hon Lung Kok, Marcus Chun Wah Yuen, Sau Hing Chan, Chor Hing Cheng, Filly Cheung
  • Method of making and administering quinoline derivatives as anti-cancer agents
    Publication number: 20090054482
    Abstract: The present invention relates methods of preparing quinoline derivative compounds, and administering such compounds in the treatment of solid and non-solid tumors, notably on liver cancer.
    Type: Application
    Filed: August 21, 2007
    Publication date: February 26, 2009
    Applicant: The Hong Kong Polytechnic University
    Inventors: Albert Sun-chi Chan, Johnny Cheuk-on Tang, Kim-hung Lam, Chung-hin Chui, Stanton Hon-lung Kok, Sau Hing Chan, Filly Cheung, Roberto Gambari, Chor Hing Cheng