Patents by Inventor Stavros G. Demos
Stavros G. Demos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240085330Abstract: Microscopy with Ultraviolet Surface Excitation (MUSE) for use in the classroom to enhance life sciences education and curricula, or for other applications, including without limitation the operating room, other medical environments, research environments, and low resource environments. MUSE's suitability is based on multiple key factors including its simplicity of use, the incorporation of inexpensive hardware including LED illumination, and very basic tissue preparation. The ultraviolet excitation acts as passive optical sectioning confining the generated fluorescence signal to only a few micrometers below the tissue surface thus eliminating the out of focus signals. This facilitates image capture of tissue microstructure and organization from specimens at the intact or sliced surface arising from varying fluorophore concentration within the different cellular compartments.Type: ApplicationFiled: November 21, 2023Publication date: March 14, 2024Applicant: UNIVERSITY OF ROCHESTERInventors: Stavros G. Demos, Chi Huang
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Patent number: 11860100Abstract: Microscopy with Ultraviolet Surface Excitation (MUSE) for use in the classroom to enhance life sciences education and curricula, or for other applications, including without limtiation the operating room, other medical environments, research environments, and low resource environments. MUSE's suitability is based on multiple key factors including its simplicity of use, the incorporation of inexpensive hardware including LED illumination, and very basic tissue preparation. The ultraviolet excitation acts as passive optical sectioning confining the generated fluorescence signal to only a few micrometers below the tissue surface thus eliminating the out of focus signals. This facilitates image capture of tissue microstructure and organization from specimens at the intact or sliced surface arising from varying fluorophore concentration within the different cellular compartments.Type: GrantFiled: January 25, 2019Date of Patent: January 2, 2024Assignee: UNIVERSITY OF ROCHESTERInventors: Stavros G. Demos, Chi Huang
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Publication number: 20230264420Abstract: Additive manufacturing systems and methods utilizing an optical light valve configured to spatially modulate the intensity of a laser beam, in conjunction with a writing and erasing sub-system configured to repeatedly write and erase patterns in the optical light valve to repeatedly vary the spatial modulation of the laser beam. In some implementations, the systems and methods may also employ additional laser beams or other energy sources that are not spatially modulated by the optical light valve. In some implementations, the systems and methods may employ additional laser beams or other energy sources configured to reduce surface roughness of the powder or other material being used for additive manufacturing.Type: ApplicationFiled: July 7, 2021Publication date: August 24, 2023Applicant: UNIVERSITY OF ROCHESTERInventors: Kenneth L. Marshall, Stavros G. Demos, Tanya Kosc
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Patent number: 11581691Abstract: A beam shaping system including an all-optical liquid crystal beam shaper, the beam shaper including a photoswitchable alignment material including at least one of a PESI-F, SPMA:MMA 1:5, SPMA:MMA 1:9, ora SOMA:SOMA-p:MMA 1:1:6 material, at least some of the liquid crystals of the beam shaper including at least one of a phenylcyclohexane, cyclo-cyclohexane, or a perfluorinated material.Type: GrantFiled: August 16, 2019Date of Patent: February 14, 2023Assignee: UNIVERSITY OF ROCHESTERInventors: Kenneth L. Marshall, Stavros G. Demos, Tanya Kosc
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Publication number: 20210063312Abstract: Microscopy with Ultraviolet Surface Excitation (MUSE) for use in the classroom to enhance life sciences education and curricula, or for other applications, including without limtiation the operating room, other medical environments, research environments, and low resource environments. MUSE's suitability is based on multiple key factors including its simplicity of use, the incorporation of inexpensive hardware including LED illumination, and very basic tissue preparation. The ultraviolet excitation acts as passive optical sectioning confining the generated fluorescence signal to only a few micrometers below the tissue surface thus eliminating the out of focus signals. This facilitates image capture of tissue microstructure and organization from specimens at the intact or sliced surface arising from varying fluorophore concentration within the different cellular compartments.Type: ApplicationFiled: January 25, 2019Publication date: March 4, 2021Applicant: UNIVERSITY OF ROCHESTERInventors: Stavros G. Demos, Chi Huang
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Publication number: 20210046586Abstract: Additive manufacturing systems and methods utilizing an optical light valve configured to spatially modulate the intensity of a laser beam, in conjunction with a writing and erasing sub-system configured to repeatedly write and erase patterns in the optical light valve to repeatedly vary the spatial modulation of the laser beam. In some implementations, the systems and methods may also employ additional laser beams or other energy sources that are not spatially modulated by the optical light valve. In some implementations, the systems and methods may employ additional laser beams or other energy sources configured to reduce surface roughness of the powder or other material being used for additive manufacturing.Type: ApplicationFiled: July 7, 2020Publication date: February 18, 2021Inventors: Kenneth L. Marshall, Stavros G. Demos, Tanya Kosc
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Publication number: 20200030916Abstract: Laser additive manufacturing apparatus, systems, and methods for the fabrication of high quality freeform high value structures. The apparatus, systems, and methods utilize a material powder having varying particle size and shape as raw material. It can also be adopted to use a wire as the feed material.Type: ApplicationFiled: October 1, 2019Publication date: January 30, 2020Inventor: Stavros G. Demos
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Patent number: 10471543Abstract: Laser additive manufacturing apparatus, systems, and methods for the fabrication of high quality freeform high value structures. The apparatus, systems, and methods utilize a material powder having varying particle size and shape as raw material. It can also be adopted to use a wire as the feed material.Type: GrantFiled: December 15, 2015Date of Patent: November 12, 2019Assignee: Lawrence Livermore National Security, LLCInventor: Stavros G. Demos
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Patent number: 10413188Abstract: A method is described to enhance the ability to evaluate the depth of a tissue component or a lesion having optical properties different from a surrounding tissue using time resolved optical methods. This invention may be particularly suitable for the evaluation of lesion depth during RF ablation (irreversible tissue modification/damage) using specially designed devises (catheters) that deliver heat in a localized region for therapeutic reasons. The technique allows for increased ability to evaluate the depth of the ablated lesion or detect the presence of other processes such as micro-bubble formation and coagulation with higher sensitivity compared to that offered by steady state spectroscopy. The method can be used for in-vivo, real-time monitoring during tissue ablation or other procedures where information on the depth of a lesion or tissue is needed. Exemplary uses are found in tissue ablation, tissue thermal damage, lesion and tissue depth assessment in medical applications.Type: GrantFiled: March 12, 2013Date of Patent: September 17, 2019Assignee: Lawrence Livermore National Security, LLCInventor: Stavros G. Demos
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Patent number: 10390709Abstract: A system for detecting pressure, acoustic or ultrasound waves within an entity having a surface including the steps of attaching a signal converting material to the surface. The waves are generated by direct ejection from the surface, generation via energy deposition on the surface, generated spontaneously or, generated by directing light energy to the light absorbing target. The absorbing target subsequently generates acoustic pressure waves. The acoustic waves propagate to the surface of the entity and the signal converting material, wherein the acoustic pressure waves create vibrations in the signal converting material; and detecting the waves in the signal converting material with an optical detection system. Information about the absorbing target is obtained by the absorbing target reflecting the waves. The signal converting material can be a gel-like material containing optical elements, a multi-layer patch, or other material.Type: GrantFiled: March 13, 2012Date of Patent: August 27, 2019Assignee: Lawrence Livermore National Security, LLCInventors: Stavros G. Demos, Alexander M. Rubenchik
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Patent number: 10182708Abstract: A system in one embodiment includes an image forming device for forming an image from an area of interest containing different image components; an illumination device for illuminating the area of interest with light containing multiple components; at least one light source coupled to the illumination device, the at least one light source providing light to the illumination device containing different components, each component having distinct spectral characteristics and relative intensity; an image analyzer coupled to the image forming device, the image analyzer decomposing the image formed by the image forming device into multiple component parts based on type of imaging; and multiple image capture devices, each image capture device receiving one of the component parts of the image. Additional systems and methods are presented.Type: GrantFiled: August 31, 2012Date of Patent: January 22, 2019Assignee: Lawrence Livermore National Security, LLCInventor: Stavros G. Demos
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Publication number: 20170165789Abstract: Laser additive manufacturing apparatus, systems, and methods for the fabrication of high quality freeform high value structures. The apparatus, systems, and methods utilize a material powder having varying particle size and shape as raw material. It can also be adopted to use a wire as the feed material.Type: ApplicationFiled: December 15, 2015Publication date: June 15, 2017Inventor: Stavros G. Demos
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Patent number: 8945440Abstract: A method of determining conditioning pulse parameters for an optical element includes directing a pump pulse to impinge on the optical element and directing a probe pulse to impinge on the optical element. The method also includes determining a first time associated with an onset of electronic excitation leading to formation of an absorbing region of the optical element and determining a second time associated with expansion of the absorbing region of the optical element. The method further includes defining a turn-off time for a conditioning pulse between the first time and the second time. According to embodiments of the present invention, pulse shaping of the conditioning pulse enables laser conditioning of optical elements to achieve improvements in their laser induced damage threshold.Type: GrantFiled: September 22, 2011Date of Patent: February 3, 2015Assignee: Lawrence Livermore National Security, LLCInventors: Stavros G. Demos, Rajesh Raman, Raluca A. Negres
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Publication number: 20130338504Abstract: A system for detecting pressure, acoustic or ultrasound waves within an entity having a surface including the steps of attaching a signal converting material to the surface. The waves are generated by direct ejection from the surface, generation via energy deposition on the surface, generated spontaneously or, generated by directing light energy to the light absorbing target. The absorbing target subsequently generates acoustic pressure waves. The acoustic waves propagate to the surface of the entity and the signal converting material, wherein the acoustic pressure waves create vibrations in the signal converting material; and detecting the waves in the signal converting material with an optical detection system. Information about the absorbing target is obtained by the absorbing target reflecting the waves. The signal converting material can be a gel-like material containing optical elements, a multi-layer patch, or other material.Type: ApplicationFiled: March 13, 2012Publication date: December 19, 2013Applicant: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC.Inventors: Stavros G. Demos, Alexander M. Rubenchik
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Publication number: 20130253330Abstract: A method is described to enhance the ability to evaluate the depth of a tissue component or a lesion having optical properties different from a surrounding tissue using time resolved optical methods. This invention may be particularly suitable for the evaluation of lesion depth during RF ablation (irreversible tissue modification/damage) using specially designed devises (catheters) that deliver heat in a localized region for therapeutic reasons. The technique allows for increased ability to evaluate the depth of the ablated lesion or detect the presence of other processes such as micro-bubble formation and coagulation with higher sensitivity compared to that offered by steady state spectroscopy. The method can be used for in-vivo, real-time monitoring during tissue ablation or other procedures where information on the depth of a lesion or tissue is needed. Exemplary uses are found in tissue ablation, tissue thermal damage, lesion and tissue depth assessment in medical applications.Type: ApplicationFiled: March 12, 2013Publication date: September 26, 2013Applicant: LAWRENCE LIVERMORE NATIONAL SECURITY, LLCInventor: Stavros G. Demos
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Patent number: 8395079Abstract: A method of repairing damage in an optical element includes providing a laser system including at least one optical element having a coating layer having an incident light surface and directing a laser pulse from the laser system to impinge on the incident light surface. The method also includes sustaining damage to a portion of the incident light surface and melting the damaged portion of the incident light surface and a region adjacent to the damaged portion. The method further includes flowing material from the region adjacent the damaged portion to the damaged portion and solidifying the material in the damaged portion and the region adjacent to the damaged portion.Type: GrantFiled: July 12, 2010Date of Patent: March 12, 2013Assignee: Lawrence Livermore National Security, LLCInventors: Stavros G. Demos, Alexander M. Rubenchik, Raluca A. Negres
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Publication number: 20130033589Abstract: A system in one embodiment includes an image forming device for forming an image from an area of interest containing different image components; an illumination device for illuminating the area of interest with light containing multiple components; at least one light source coupled to the illumination device, the at least one light source providing light to the illumination device containing different components, each component having distinct spectral characteristics and relative intensity; an image analyzer coupled to the image forming device, the image analyzer decomposing the image formed by the image forming device into multiple component parts based on type of imaging; and multiple image capture devices, each image capture device receiving one of the component parts of the image. Additional systems and methods are presented.Type: ApplicationFiled: August 31, 2012Publication date: February 7, 2013Applicant: LAWRENCE LIVERMORE NATIONAL SECURITY, LLCInventor: Stavros G. Demos
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Patent number: 8320650Abstract: In vivo endoscopic methods an apparatuses for implementation of fluorescence and autofluorescence microscopy, with and without the use of exogenous agents, effectively (with resolution sufficient to image nuclei) visualize and categorize various abnormal tissue forms.Type: GrantFiled: November 9, 2009Date of Patent: November 27, 2012Assignees: Lawrence Livermore National Security, LLC, The Regents of the University of CaliforniaInventors: Stavros G. Demos, Shiro Urayama, Bevin Lin, Ramez Moussa Ghobrial Saroufeem
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Patent number: 8285015Abstract: A system in one embodiment includes an image forming device for forming an image from an area of interest containing different image components; an illumination device for illuminating the area of interest with light containing multiple components; at least one light source coupled to the illumination device, the at least one light source providing light to the illumination device containing different components, each component having distinct spectral characteristics and relative intensity; an image analyzer coupled to the image forming device, the image analyzer decomposing the image formed by the image forming device into multiple component parts based on type of imaging; and multiple image capture devices, each image capture device receiving one of the component parts of the image.Type: GrantFiled: July 2, 2008Date of Patent: October 9, 2012Assignee: Lawrence Livermore Natioonal Security, LLCInventor: Stavros G. Demos
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Patent number: 8190242Abstract: Portable, field-deployable laser synthesizer devices designed for multi-dimensional spectrometry and time-resolved and/or hyperspectral imaging include a coherent light source which simultaneously produces a very broad, energetic, discrete spectrum spanning through or within the ultraviolet, visible, and near infrared wavelengths. The light output is spectrally resolved and each wavelength is delayed with respect to each other. A probe enables light delivery to a target. For multidimensional spectroscopy applications, the probe can collect the resulting emission and deliver this radiation to a time gated spectrometer for temporal and spectral analysis.Type: GrantFiled: July 22, 2009Date of Patent: May 29, 2012Assignee: Lawrence Livermore National Security, LLCInventors: Stavros G. Demos, Miroslav Y. Shverdin, Michael D. Shirk