Abstract: Disclosed is an auto injector and a method for administering a medicament. The auto injector comprising: a housing; a cartridge receiver; a drive module coupled to move a plunger rod configured to move a first stopper; a temperature sensor configured to provide a temperature signal indicative of the temperature of the medicament in the cartridge; a processing unit configured to: receive the temperature signal; control the drive module to move the plunger rod from a first plunger rod position to a mix plunger rod position wherein the movement from the first plunger rod position to the mix plunger rod position is based on the temperature signal.

Abstract: Disclosed is an auto injector for administering a medicament. The auto injector comprising: a housing; a cartridge receiver configured to receive a cartridge assembly comprising a cartridge (700) and a cartridge code (1000) feature, the cartridge containing the medicament; a code sensor configured to read the cartridge code feature; a drive module coupled to move a plunger rod; and a processing unit coupled to the code sensor and the drive module. The processing unit being configured to: receive from the code sensor a code signal indicative of the cartridge code feature; control the drive module to move the plunger rod to a first plunger rod position, the first plunger rod position being based on the code signal; receive a trigger event; control the drive module to move the plunger rod to a second plunger rod position following reception of the trigger event.

Abstract: The present invention relates to a polymeric human growth hormone prodrug and dry, liquid and reconstituted pharmaceutical formulations comprising said prodrug. It furthermore relates to their use as medicaments for the treatment of diseases which can be treated with growth hormone and to methods of treatment. It also relates to methods of application of such polymeric human growth hormone prodrug or pharmaceutical formulation.

Abstract: The invention concerns one or more floating barriers for use together with a conventional floating barrier for use in collecting oil on a water surface. The floating barriers are of the kind where the submerged part is partially penetrable for water and oil, thereby providing an impeding but not blocking effect on a passing flow of water. The function of the floating barriers is based on the fact that by disposition upstream relative to the conventional floating barrier and together with the latter they will constitute a total system which can be moved through an oil-contaminated body of water with substantially greater speed than a conventional floating barrier, without leaking oil behind the floating barrier system. The invention particularly concerns conditions of the geometry, spacing and draught of the water-penetrable liquid barriers.

Abstract: The present invention relates to anti-human PAX 5 antibodies capable of binding to one or more epitopes located within the C-terminal regulatory domain of PAX 5. In particular the invention relates to an antibody, antigen binding fragment or recombinant protein thereof, which is capable of specific binding to an epitope located within the C-terminal fragment of human PAX 5 protein, wherein said epitope comprises from 3 to 17 amino acid residues of amino acid sequence GSPYYYSAAARGAAPPA (SEQ ID NO:2). The invention also relates to immunogenic peptide sequences for the production of the antibodies, diagnostic and therapeutic applications comprising using the antibodies and formulations comprising thereof.

Abstract: An apparatus for cooling, comprising: a liquid pump for transport of fluid through a heating cycle, an external heat source for heating the fluid in the heating cycle, for example a solar heater directly connected to the heating cycle or connected through a heat exchanger, an expander with an expander inlet and an expander outlet, the expander inlet having a fluid connection to the external heat source for receiving fluid in the gas phase to drive the expander by expanding the fluid, a compressor with a compressor inlet and a compressor outlet, the compressor being driven by the expander for compressing working fluid from a low pressure compressor inlet gas to a high pressure compressor outlet gas, a first heat exchanger with a fluid connection to the compressor outlet and connected to the expander inlet for transfer of heat from the high pressure compressor outlet gas to the fluid in the heating cycle, a second heat exchanger with a condenser for condensing the working fluid from the expander by energy trans

Abstract: The present invention relates to novel anti-human PAX 5 antibodies capable of binding to one or more epitopes located within the C-terminal regulatory domain of PAX 5. In particular the invention relates to an antibody, antigen binding fragment or recombinant protein thereof, which is capable of specific binding to an epitope located within the C-terminal fragment of human PAX 5 protein, wherein said epitope comprises from 3 to 17 amino acid residues of amino acid sequence GSPYYYSAAARGAAPPA (SEQ ID NO:2). The invention also relates to immunogenic peptide sequences for the production of the antibodies, diagnostic and therapeutic applications comprising using the antibodies and formulations comprising thereof.

Abstract: An apparatus for cooling, comprising: a liquid pump for transport of fluid through a heating cycle, an external heat source for heating the fluid in the heating cycle, for example a solar heater directly connected to the heating cycle or connected through a heat exchanger, an expander with an expander inlet and an expander outlet, the expander inlet having a fluid connection to the external heat source for receiving fluid in the gas phase to drive the expander by expanding the fluid, a compressor with a compressor inlet and a compressor outlet, the compressor being driven by the expander for compressing working fluid from a low pressure compressor inlet gas to a high pressure compressor outlet gas, a first heat exchanger with a fluid connection to the compressor outlet and connected to the expander inlet for transfer of heat from the high pressure compressor outlet gas to the fluid in the heating cycle, a second heat exchanger with a condenser for condensing the working fluid from the expander by energy trans

Abstract: A device having a first flow meter (2) and a second flow meter (3). The first and the second flow meters work according to a Coriolis principle. The first flow meter includes a first measuring tube (7). The second flow meter includes a second measuring tube (10). The first flow meter and the second flow meter are disposed in a common housing (4,5,6). The first flow meter and the second flow meters have different eigenfrequencies because of a first vibration-influencing device (18) attached to the first flow meter and a second vibration-influencing device (19) attached to the second flow meter.

Abstract: Insulin preparations of superior physical stability, comprising dissolved and/or precipitated human insulin or an analogue or derivative thereof, and a water-soluble reduced or non-reducing carbohydrate containing at least 4 carbon atoms in the main carbohydrate structure, or a water-soluble non-reducing ester and/or ether derivative of a carbohydrate or reduced carbohydrate containing at least 4 carbon atoms in the main carbohydrate structure, or mixtures thereof are disclosed.

Abstract: The present invention relates to a process for producing a therapeutic powder formulation, comprising (a) providing an acidic aqueous solution comprising an insulin or analoguc or derivative thereof and an enhancer; (b) adjusting the pH to a pH in the range of 4.5 to 7.4; (c) precipitating a product comprising the insulin or analogue or derivative thereof and the enhancer, wherein the precipitation is performed essentially without evaporation of the solution; and (d) removing the water.

Abstract: Insulin preparations of superior physical stability, comprising dissolved and/or precipitated human insulin or an analogue or derivative thereof, and a water-soluble reduced or non-reducing carbohydrate containing at least 4 carbon atoms in the main carbohydrate structure, or a water-soluble non-reducing ester and/or ether derivative of a carbohydrate or reduced carbohydrate containing at least 4 carbon atoms in the main carbohydrate structure, or mixtures thereof are disclosed.

Abstract: A therapeutic powder formulation suitable for pulmonary administration comprising particles composed of human insulin or any analogue or derivative thereof and an enhancer which enhances the absorption of insulin in the lower respiratory tract, wherein at least 50% by weight of the particles are crystalline.

Abstract: The present invention relates to a pharmaceutical preparation comprising glucagon and a stabilizing amount of a pharmaceutically acceptable ampholyte, especially an amino acid or dipeptide or a mixture thereof and optionally an excipient.The preparation is stable for extended periods of time in solution at room temperature.