Abstract: The invention provides methods and compositions for hybridizing at least one molecule to a target. The invention may, for example, eliminate the use of, or reduce the dependence on formamide in hybridization. Compositions for use in the invention include an aqueous composition comprising at least one nucleic acid sequence and at least one polar aprotic solvent in an Camount effective to denature double-stranded nucleotide sequences.

Abstract: A packaging container for dry, tricklable products, with the container being produced by folding and fixing of a flat carton member prepunched and provided with folding lines. The container includes a reclosable pouring spout at an upper end portion and is adapted to be filled from a closable bottom end thereof. The pouting spout includes a middle lid portion which, from a transverse upper edge of a short narrow side of the container, is upwardly inclined toward an opposite narrow side thereof. The lid portion, at a distance from the upper edge, has a projecting tongue forming a breakable seal adapted to be fixed to a planar top side portion of the container. A locking tongue, upon a reclosing of the pouring spout, is adapted to be inserted under a transverse free end edge portion of the top side portion.