Abstract: The present invention provides ingestible dosage form articles such as opaque capsules with reduced light transmittance.

Abstract: A process for making multiparticulates, comprising providing a molten feed comprising an active ingredient and an excipient, and providing a spinning disc sprayer comprising a rotating disc having a feed-receiving surface driven from above by a hollow drive shaft, wherein axes of rotation of the hollow drive shaft and rotatable disc are coaxial and a downward end of the hollow drive shaft is disposed with a distributor for regulating flow of the molten feed into the well, the distributor and the well together configured for providing a substantially radial, uniform outward flow of the molten feed across the feed-receiving surface.

Abstract: The present invention provides ingestible dosage form articles such as opaque capsules with reduced light transmittance.

Abstract: The present invention provides ingestible dosage form articles such as opaque capsules with reduced light transmittance.

Abstract: An aqueous composition for making dip-molded comestible hard capsules comprising a film forming capsule base material and one or more colorants each consisting of a hydrophilic coloring foodstuff concentrate.

Abstract: An aqueous composition for making dip-molded comestible hard capsules comprising a film forming capsule base material and one or more colorants each consisting of a hydrophilic coloring foodstuff concentrate.

Abstract: An acid resistant capsule comprises at least one hard capsule shell, said shell comprising: an enteric polymer having acid groups; a film-forming aid; and an alkaline material, wherein said alkaline material is present in an amount such that said carboxylic acid groups of said enteric polymer have a degree of ionization of less than 15%.

Abstract: The present invention provides ingestible dosage form articles such as opaque capsules with reduced light transmittance.

Abstract: An apparatus for dosing solid particulate material into one or more receptacles, the apparatus comprising: a reservoir for containing an amount of solid particulate material; a dosing unit comprising a dose collection position for collecting a predetermined dose of solid particulate material from the reservoir, and a dose release position for releasing the solid particulate material into the one or more receptacles; a receptacle handling unit for retaining the one or more receptacles, arranged to at least periodically align at least one of the one or more receptacles with the dosing unit when in the dose release position; and optionally a receptacle closing unit for closing the one or more receptacles once filled with the solid particulate material; wherein the dosing unit comprises one or more dosing chambers arranged to displace relative to said reservoir, and/or vice versa, along a perpendicular axis Y such that at least a portion of the chamber(s) is capable of being immerged into, and emerged out of, the

Abstract: An apparatus for aseptic sealing a capsule having coaxial parts that at least partly overlap when telescopically joined, certain embodiments of the apparatus comprising: a capsule carrier assembly provided with at least one cavity for accommodating a respective capsule therein; a clamping member comprising a first half and a second half disposed on either side of the cavity at a capsule processing station, and each half arranged to linearly displace towards the cavity containing the capsule to a clamped position over and/or around at least a portion of the capsule; wherein the clamping member comprises a sealing means adapted to apply a sealing fluid uniformly to a circumferential gap around the capsule to be sealed when in the clamped position, and wherein the clamping member further comprises a suction means adapted to provide an area of low pressure around the capsule after application of the sealing fluid so as to remove any excess sealing fluid from the capsule when in the same clamped position.

Abstract: A tamperproof dosage form article comprising: a core, wherein the core comprises a first end and a second end; a first shell on at least a portion of the first end of the core; a second shell on at least a portion of the second end of the core; wherein the first and second shells comprise one or more locking protrusions extending along at least a portion of the circumference and inner surface of the shells, and the core comprises one or more locking recesses, and wherein at least a portion of the shells proximal to the locking protrusions is elastically deformable and arranged such that each one locking protrusion is snapped into each one of the locking recesses once inserted over a predetermined portion of the core to provide a locking force between the core and the shells.

Abstract: An aqueous composition for making dip-molded comestible hard capsules comprising a film forming capsule base material and one or more colorants each consisting of a hydrophilic coloring foodstuff concentrate.

Abstract: A comestible dosage form article, in the form of a hard capsule, for administration to a target subject, the dosage form comprising at least one body and at least one cap telescopically engageable with the body, the cap and the body being separable such to allow dispensing of a contents therefrom. The capsule comprising a sensory trigger over at least a portion of the outer surface of the capsule arranged to provide a visual, taste, and/or tactile deterrence to ingestion thereof.

Abstract: An aqueous composition for making dip-molded comestible hard capsules comprising a film forming capsule base material and one or more colorants each consisting of a hydrophilic coloring foodstuff concentrate.

Abstract: The present disclosure relates to a separable hard capsule for containing a medication. The capsule may be opened by finger force and used, for example, by pediatric and geriatric patients.

Abstract: A comestible dosage form article for administration to a target subject, the dosage form comprising: an outer capsule comprising a first cap telescopically engageable with a first body; and an inner capsule, within the outer capsule, comprising a second cap telescopically engageable with a second body, wherein the inner capsule is inverted with respect to the outer capsule such that, in an assembled state, the second cap is proximal to the first body and distal to the first cap.

Abstract: A tamperproof dosage form for oral administration comprising: a caplet comprising first and second ends, a middle region extending between said first and second ends, parallel and oppositely disposed top and bottom faces, and a land interposed between the top and bottom faces and extending along a perimeter of the caplet on a plane parallel to a caplet length axis; and first and second shells, each comprising an open end and a closed dome-shaped end, each fitted over at least a portion of the caplet, the portion comprising at least the first and/or second ends of the caplet and at least part of the middle region. An adhesive substance being arranged between the caplet and the shells at least over a portion of the top and/or bottom faces proximal to the first and second ends of the caplet and a corresponding portion of an inner surface of the closed dome-shaped end of the shells to fixedly join the shells to the caplet.

Abstract: A tamperproof dosage form for oral administration comprising: a caplet comprising first and second ends, a middle region extending between said first and second ends, parallel and oppositely disposed top and bottom faces, and a land interposed between the top and bottom faces and extending along a perimeter of the caplet on a plane parallel to a caplet length axis; and first and second shells, each comprising an open end and a closed dome-shaped end, each fitted over at least a portion of the caplet, the portion comprising at least the first and/or second ends of the caplet and at least part of the middle region. An adhesive substance being arranged between the caplet and the shells at least over a portion of the top and/or bottom faces proximal to the first and second ends of the caplet and a corresponding portion of an inner surface of the closed dome-shaped end of the shells to fixedly join the shells to the caplet.

Abstract: An aqueous composition for making dip-molded comestible hard capsules comprising a film forming capsule base material and one or more colorants each consisting of a hydrophilic coloring foodstuff concentrate.

Abstract: An acid resistant capsule comprises at least one hard capsule shell, said shell comprising: an enteric polymer having acid groups; a film-forming aid; and an alkaline material, wherein said alkaline material is present in an amount such that said carboxylic acid groups of said enteric polymer have a degree of ionization of less than 15%.