Patents by Inventor Stefan Ambs

Stefan Ambs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and Compositions for the Treatment of Prostate Related Disorders using miR-106b
    Publication number: 20170211066
    Abstract: Methods and compositions for the treatment of prostate associated disorders are disclosed.
    Type: Application
    Filed: April 6, 2017
    Publication date: July 27, 2017
    Applicants: The Ohio State University Research Foundation, The Government of the United States of America, as represented by the Secretary of the Department of
    Inventors: Carlo M. Croce, Stefan Ambs
  • Methods and Compositions for the Treatment of Prostate Related Disorders using miR-1
    Publication number: 20160186184
    Abstract: Methods and compositions for the treatment of prostate associated disorders are disclosed.
    Type: Application
    Filed: March 7, 2016
    Publication date: June 30, 2016
    Applicants: The Ohio State University Research Foundation, The Government of the United States of America, as represented by the Secretary of the Department of
    Inventors: Carlo M. Croce, Stefan Ambs
  • Methods and Compositions for Increasing the Efficacy of Doxorubicin Treatment in the Treatmentof Prostate Related Disorders using miR-106b-25 Cluster
    Publication number: 20160177316
    Abstract: Methods and compositions for the treatment of prostate associated disorders are disclosed.
    Type: Application
    Filed: March 7, 2016
    Publication date: June 23, 2016
    Applicants: The Ohio State University Research Foundation, The Government of the United States of America, as represented by the Secretary of the Department of
    Inventors: Carlo M. Croce, Stefan Ambs
  • Methods and Compositions for the Treatment of Prostate Related Disorders using miR-32
    Publication number: 20160177312
    Abstract: Methods and compositions for the treatment of prostate associated disorders are disclosed.
    Type: Application
    Filed: March 7, 2016
    Publication date: June 23, 2016
    Applicants: The Ohio State University Research Foundation, The Government of the United States of America, as represented by the Secretary of the Department of
    Inventors: Carlo M. Croce, Stefan Ambs
  • Methods and Compositions for the Treatment of Prostate Related Disorders using miR-106b
    Publication number: 20160177311
    Abstract: Methods and compositions for the treatment of prostate associated disorders are disclosed.
    Type: Application
    Filed: March 7, 2016
    Publication date: June 23, 2016
    Applicants: The Ohio State University Research Foundation, The Government of the United States of America, as represented by the Secretary of the Department of
    Inventors: Carlo M. Croce, Stefan Ambs
  • Manganese superoxide dismutase Val16Ala polymorphism predicts resistance to chemotherapeutic drug cancer therapy
    Patent number: 7985561
    Abstract: The present invention provides, for the first time, the finding that the manganese superoxide dismutase Val16Ala polymorphism is significantly associated with prognosis for cancer patients treated with chemotherapeutic drug therapy. The alanine allele is a novel biomarker that predicts poor response and poor outcome to chemotherapeutic drug cancer therapy. Conversely, the valine allele predicts a good response and a good outcome to chemotherapeutic drug cancer therapy. Therefore, a genotype assay can be used to determine which alleles a subject is carrying, and subsequently this information can be used to determine if chemotherapeutic drug therapy is appropriate, and to customize therapy according to the patient's MnSOD genotype.
    Type: Grant
    Filed: November 11, 2008
    Date of Patent: July 26, 2011
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Stefan Ambs, Brenda Boersma
  • MicroRNA-Based Methods and Compositions for the Diagnosis, Prognosis and Treatment of Prostate Related Disorders
    Publication number: 20110054009
    Abstract: Methods and compositions for the diagnosis, prognosis and/or treatment of prostate associated disorders are disclosed.
    Type: Application
    Filed: February 27, 2009
    Publication date: March 3, 2011
    Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Carlo M. Croce, Stefan Ambs
  • MANGANESE SUPEROXIDE DISMUTASE VAL16ALA POLYMORPHISM PREDICTS RESISTANCE TO CHEMOTHERAPEUTIC DRUG CANCER THERAPY
    Publication number: 20090136952
    Abstract: The present invention provides, for the first time, the finding that the manganese superoxide dismutase Val16Ala polymorphism is significantly associated with prognosis for cancer patients treated with chemotherapeutic drug therapy. The alanine allele is a novel biomarker that predicts poor response and poor outcome to chemotherapeutic drug cancer therapy. Conversely, the valine allele predicts a good response and a good outcome to chemotherapeutic drug cancer therapy. Therefore, a genotype assay can be used to determine which alleles a subject is carrying, and subsequently this information can be used to determine if chemotherapeutic drug therapy is appropriate, and to customize therapy according to the patient's MnSOD genotype.
    Type: Application
    Filed: November 11, 2008
    Publication date: May 28, 2009
    Applicants: Human Services
    Inventors: Stefan Ambs, Brenda Boersma
  • p53 and VEGF regulate tumor growth of NOS2 expressing cancer cells
    Publication number: 20070056049
    Abstract: The invention provides, for example, in vitro and in vivo methods for screening modulators of NOS-2 activity using p53 mutant cells, methods of predicting the benefit of administering NOS-2 inhibitors to a cancer patient, and methods of treating cancer by administering NOS-2 inhibitors to patients with p53 mutant cancers.
    Type: Application
    Filed: August 1, 2005
    Publication date: March 8, 2007
    Applicant: The Govt. of the USA as represented by the Secretary of the Dept. of Health & Human Services
    Inventors: Stefan Ambs, Curtis Harris