Abstract: What is described are BET protein-inhibitory, in particular BRD4-inhibitory 2,3-benzodiazepines of the general formula (I) in which R1a, R1b, R1c, R2, R3, R4, R5, A and X have the meanings given in the description, intermediates for preparing the compounds according to the invention, pharmaceutical compositions comprising the compounds according to the invention and their prophylactic and therapeutic use for hyperproliferative disorders, in particular for tumour disorders. Also described is the use of BET protein inhibitors for benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, for neurodegenerative disorders, for inflammatory disorders, for atherosclerotic disorders and for the control of male fertility.

Abstract: Spiroindoline derivatives, process for their preparation and pharmaceutical compositions thereof, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially sex-hormone-related diseases in both men and women, in particularly those selected from the group of endometriosis, uterine fibroids, polycystic ovarian disease, hirsutism, precocious puberty, gonadal steroid-dependent neoplasia such as cancers of the prostate, breast and ovary, gonadotrope pituitary adenomas, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hypertrophy, contraception and infertility (e.g., assisted reproductive therapy such as in vitro fertilization). The present application relates in particular to spiroindoline derivatives as gonadotropin-releasing hormone (GnRH) receptor antagonists.

Abstract: A controller for use in a power converter includes an oscillator that generates a first signal that determines a duration of a switching cycle period of a switch included in the power converter. The controller also includes a logic circuit that generates a second signal to control switching of the switch in response to a feedback signal and in response to the first signal. The logic circuit generates the second signal to control a peak switch current of the switch during each switching cycle period according to either a first mode of operation or a second mode of operation. The peak switch current of the switch is varied in the first mode of operation in response to the feedback signal indicating that an output load is greater than a threshold and the peak switch current of the switch is kept at a constant value in the second mode of operation in response to the feedback signal indicating that the output load is less than the threshold.

Abstract: An example controller for use in a power converter includes an oscillator that is to be coupled to a switch of the power converter to determine a switching cycle period of the switch. The controller also includes means for controlling a duty cycle of the switch to regulate an output of the power converter and for maintaining a substantially constant rate of change of the duty cycle with respect to changes in a magnitude of a feedback signal as the controller transitions between duty cycle control modes such that a control loop gain of the power converter is substantially constant during the transition.

Abstract: A power converter includes an energy transfer element and a power switch coupled the energy transfer element and an input of the power converter. A control circuit is coupled to generate a switching signal to control switching of the power switch in response to a feedback signal representative of an output of the power converter. A programming interface circuit is coupled to the control circuit and a coupling switcher coupled to the programming interface circuit. A programming terminal is selectively coupled to the programming interface circuit through the coupling switcher. A programming circuit coupled to the programming terminal is coupled to the programming interface circuit through the coupling switcher during a startup programming condition and during a fault condition of the power converter, and is decoupled from the programming interface circuit by the coupling switcher during a normal operating condition of the power converter.

Abstract: A controller includes a current sense circuit and a voltage regulation circuit. The current sense circuit generates a first signal that indicates whether a current through a sense terminal exceeds a first threshold current level, which indicates a fault condition of a power converter. The voltage regulation circuit regulates the sense terminal to a first voltage level when the current through the terminal is less than the first threshold current level and regulates the sense terminal to a second voltage level when the current exceeds the first threshold current level. The current sense circuit generates a second signal that indicates whether the current through the sense terminal exceeds a second threshold current level while the sense terminal is regulated to the second voltage level. The response circuit generates an output signal that determines a response of the controller to the fault condition based on the second signal.

Abstract: A timing circuit of a controller generates a clock signal having a switching period for use by a pulse width modulation (PWM) circuit to control a switch of a power supply. The switching period of the clock signal is based on a charging time plus a discharging time of a capacitor included in the timing circuit. A first current source charges the capacitor while the timing circuit is in a normal charging mode. A second current source charges the capacitor while the timing circuit is in an alternative charging mode that is when the on time of the switch exceeds a threshold time. The current provided by the second current source is less than the current provided by the first current source such that the switching period of the clock signal is increased in response to the timing circuit entering the alternative charging mode.

Abstract: A power converter controller is disclosed. An example controller includes a control circuit coupled to receive a feedback signal representative of an output of the power converter. The control circuit coupled to control a switching of a power switch of the power converter in response to the feedback signal to control a transfer of energy from an input of the power converter to the output of the power converter. An internal programming interface circuit is coupled to the control circuit. A coupling switcher is coupled to the internal programming interface circuit. An external programming terminal is selectively coupled to the internal programming interface circuit through the coupling switcher. An external programming circuit coupled to the external programming terminal is coupled to the internal programming interface circuit through the coupling switcher during a startup programming condition and during a fault condition of the power converter.

Abstract: A timing circuit of a controller generates a clock signal having a switching period for use by a pulse width modulation (PWM) circuit to control a switch of a power supply. The switching period of the clock signal is based on a charging time plus a discharging time of a capacitor included in the timing circuit. A first current source charges the capacitor while the timing circuit is in a normal charging mode. A second current source charges the capacitor while the timing circuit is in an alternative charging mode that is when the on time of the switch exceeds a threshold time. The current provided by the second current source is less than the current provided by the first current source such that the switching period of the clock signal is increased in response to the timing circuit entering the alternative charging mode.

Abstract: An example integrated circuit controller for use in a switching power supply includes a pulse width modulation (PWM) circuit and a timing circuit. The PWM circuit controls a switch to regulate an output of the power supply in response to a switch current flowing through the switch and in response to a clock signal having a switching period. The timing circuit provides the clock signal and increases the switching period in response to an on time of the switch exceeding a threshold time.

Abstract: A power supply includes an energy transfer element, a switch, and a controller. The controller includes a modulator, a drive signal generator, a comparator, and a variable current limit generator. The modulator generates an enable signal having logic states responsive to a feedback signal. The drive signal generator either enables or skips enabling a switch of the power supply during a switching period in response to the logic state of the enable signal. The comparator asserts an over current signal to disable the switch if the switch current exceeds a variable current limit. The variable current limit generator sets the variable current limit to a first current limit in response to one logic state of the enable signal and sets the variable current limit to a second current limit if the enable signal transitions logic states and the over current signal is asserted during the switching period.

Abstract: A method, in a power supply controller, of responding to an increase in current through a terminal of the power supply controller, is disclosed. The method includes regulating the terminal to a first voltage level and sensing a magnitude of a first current through the terminal while the controller is regulating the terminal to the first voltage level. The method also includes providing an initial response by the power supply controller in response to the magnitude of the first current exceeding a first threshold current level and then regulating the terminal to a second voltage level after the magnitude of the first current exceeds the first threshold current level. The magnitude of a second current through the terminal is sensed while the controller is regulating the terminal to the second voltage level and the controller determines a final response based on the magnitude of the second current.

Abstract: An example integrated circuit controller includes a pulse width modulation (PWM) circuit and a timing circuit. The PWM circuit controls a switch to regulate an output of a power supply in response to a switch current flowing through the switch and in response to a clock signal having a switching period. The timing circuit provides the clock signal and includes a timing capacitor where the switching period of the clock signal is equal to a charging time that the timing capacitor charges to an upper reference voltage plus a discharging time that the timing capacitor discharges to a lower reference voltage. The timing circuit increases the charging time of the timing capacitor by decreasing a rate at which the timing capacitor is charged to increase the switching period of the clock signal if an on time of the switch is greater than or equal to a threshold time.

Abstract: A package for a semiconductor die includes a die attach pad that provides an attachment surface area for the semiconductor die, and tie bars connected to the die attach pad. The die attach pad is disposed in a first general plane and the tie bars are disposed in a second general plane offset with respect to the first general plane. A molding compound encapsulates the semiconductor die in a form having first, second, third and fourth lateral sides, a top and a bottom. The tie bars are exposed substantially coincident with at least one of the lateral sides. The form includes a discontinuity that extends along the at least one of the lateral sides, the discontinuity increasing a creepage distance measured from the tie bars to the bottom of the package.

Abstract: An example controller for a power converter to provide power to a load through a distribution network includes a control circuit and a cable drop compensator. The control circuit outputs a drive signal to control switching of a switch to regulate an output of the power converter in response to a feedback signal. The cable drop compensator is coupled to adjust the feedback signal in response to a conduction time of an output diode of the power converter to compensate for a distribution voltage dropped across the distribution network.

Abstract: An example power supply controller includes a switch duty cycle controller coupled to receive a feedback signal and a duty cycle adjust signal. The switch duty cycle controller is coupled to generate a drive signal coupled to control switching of a switch, which is coupled to an energy transfer element, to regulate energy delivered from an input of a power supply to an output of the power supply. The power supply controller also includes a gain selector circuit coupled to receive an input voltage signal, which is representative of an input voltage to the power supply, to generate the duty cycle adjust signal received by the switch duty cycle controller. The duty cycle of the drive signal to be varied in response to a plurality of linear functions over a range of values of the input voltage signal.

Abstract: An example integrated circuit controller includes a pulse width modulation (PWM) circuit and a timing circuit. The PWM circuit controls a switch to regulate an output of a power supply in response to a switch current flowing through the switch and in response to a clock signal having a switching period. The timing circuit provides the clock signal and includes a timing capacitor where the switching period of the clock signal is equal to a charging time that the timing capacitor charges to an upper reference voltage plus a discharging time that the timing capacitor discharges to a lower reference voltage. The timing circuit increases the charging time of the timing capacitor by decreasing a rate at which the timing capacitor is charged to increase the switching period of the clock signal if an on time of the switch is greater than or equal to a threshold time.

Abstract: An example integrated circuit controller for use in a switching power supply includes a pulse width modulation (PWM) circuit and a timing circuit. The PWM circuit controls a switch to regulate an output of the power supply in response to a switch current flowing through the switch and in response to a clock signal having a switching period. The timing circuit provides the clock signal and increases the switching period in response to an on time of the switch exceeding a threshold time.

Abstract: A power converter controller is disclosed. An example controller includes a control circuit coupled to receive a feedback signal representative of an output of the power converter. The control circuit coupled to control a switching of a power switch of the power converter in response to the feedback signal to control a transfer of energy from an input of the power converter to the output of the power converter. An internal programming interface circuit is coupled to the control circuit. A coupling switcher is coupled to the internal programming interface circuit. An external programming terminal is selectively coupled to the internal programming interface circuit through the coupling switcher. An external programming circuit coupled to the external programming terminal is coupled to the internal programming interface circuit through the coupling switcher during a startup programming condition and during a fault condition of the power converter.

Abstract: An example controller for use in a power converter includes an oscillator that is to be coupled to a switch of the power converter to determine a switching cycle period of the switch. The controller also includes means for controlling a duty cycle of the switch to regulate an output of the power converter and for maintaining a substantially constant rate of change of the duty cycle with respect to changes in a magnitude of a feedback signal as the controller transitions between duty cycle control modes such that a control loop gain of the power converter is substantially constant during the transition.