Abstract: An optical system for shaping a laser beam includes an optical element with a base member having a lower base, an upper base, and a lateral surface. The lateral surface includes a transmitting surface for the laser beam, and the base member includes a first cutout portion having a lower base arranged in the upper base of the base member, and a lateral surface that has a first reflecting surface for the laser beam and generates an at least segmentally ring-shaped laser beam. The base member includes a second cutout portion having a lower base arranged in the lower base of the base member, an upper base that includes a transmitting surface for the laser beam, and a lateral surface abutting the lower and upper base. The lateral surface includes a second reflecting surface for the at least segmentally ring-shaped laser beam.

Abstract: A compound comprising three components A, B, and C, which components are covalently bound forming the compound having the structure A-B-C wherein component A has a specific binding affinity for antigens, component B is covalently linked to component A component C is a compound having an alkylated purine or pyrimidine moiety such as guanine, cytosine or a Coenzyme A moiety and linked thereto a moiety having a physiological effect with the proviso that component B has an catalytical or acceptor activity to couple component C with covalently coupled components A-B.

Abstract: A process is disclosed which enables the establishing of comprehensive immunoglobulin-specific reaction profiles of subjects with disorders of the immune function by the individual V gene repertoire of Ig-expressing B cells. The process comprises the isolation of B cells from body fluids, the isolation of individual B cells and their genetic material, the amplification of nucleic acids coding the variable regions of an antibody expressed by a B cell, the recombinant preparation of antibodies by expressing the amplificates, and the determination of the binding capability of the recombinant antibody to antigens.

Abstract: A silicon-ceramic composite substrate includes a low-temperature ceramic having at least one pre-formed ceramic layer and a silicon substrate. The low-temperature ceramic forms a carrier layer and the silicon substrate surface has a contact area with nanostructures) that completely penetrate into the low-temperature ceramic.

Abstract: An optical system for shaping a laser beam is disclosed. The optical system includes an optical element with a base member having a lower base, an upper base, and a lateral surface. The lateral surface includes a transmitting surface for the laser beam, and the base member includes a first cutout portion having a lower base arranged in the upper base of the base member, and a lateral surface that has a first reflecting surface for the laser beam and generates an at least segmentally ring-shaped laser beam. The base member includes a second cutout portion having a lower base arranged in the lower base of the base member, an upper base that includes a transmitting surface for the laser beam, and a lateral surface abutting the lower and upper base. The lateral surface includes a second reflecting surface for the at least segmentally ring-shaped laser beam.

Abstract: The invention relates to a silicon-ceramic composite substrate (01), which comprises a low-temperature ceramic (02) having at least one pre-structured ceramic layer and a silicon substrate (03). According to the invention, the low-temperature ceramic (02) forms a carrier layer and the silicon substrate surface has nanostructures (06), which are completely penetrated into the low-temperature ceramic (02), in a contact area (04) with the carrier layer.

Abstract: A compound comprising three components A, B, and C, which components are covalently bound forming the compound having the structure A-B-C wherein component A has a specific binding affinity for antigens, component B is covalently linked to component A component C is a compound having an alkylated purin or pyrimidin moiety such as guanin, cytosin or a Coenzyme A moiety and linked thereto a moiety having a physiological effect with the proviso that component B has an catalytical or acceptor activity to couple component C with covalently coupled components A-B.

Abstract: A process is disclosed which enables the establishing of comprehensive immunoglobulin-specific reaction profiles of subjects with disorders of the immune function by the individual V gene repertoire of Ig-expressing B cells.

Abstract: Subject of the invention is a compound, consisting of a targeting moiety which specifically binds to a disease related cell surface marker, a nucleic acid which specifically induces cell death and a linker, wherein the linker covalently links the targeting moiety to the nucleic acid. Subject of the invention are also medicaments comprising the compound and their use as a medicament for the treatment of diseases, including proliferative diseases.

Abstract: A synthetic, soluble, endogenous complex formed from at least one component A and at least one component B, whereby component A comprises a binding domain for extra-cellular surface structures that internalize upon binding of component A of said complex, and component B has a constitutive catalytic kinase activity and effects cell biosynthesis/signalling including cell death after internalization. The complex allows to influence the growth and the physiology of cells. In particular said complex, nucleic acid molecules encoding it, cells transfected or transformed with these nucleic acid molecules are usable for the preparation of medicaments for the treatment of proliferative diseases, inflammatory diseases, allergies and autoimmune diseases.

Abstract: A complex at least formed from at least one component A and at least one component B, wherein component A has a binding activity for cellular surface structures, and component B carries a protease or derivatives thereof as an effector function.

Abstract: A pharmaceutical formulation containing at least one protein-containing substance and at least one substance selected from the group of compatible solutes.

Abstract: The invention relates to biochips for documenting of specific molecule-molecule interactions or cell-molecule interactions, more particularly unknown singular protein interactions. The invention also relates to corresponding methods for selecting and characterizing molecules, especially polypeptides and the complementary binding molecules.

Abstract: A pharmaceutical formulation containing at least one protein-containing substance and at least one substance selected from the group of compatible solutes.

Abstract: A complex at least formed from at least one component A and at least one component B, wherein component A has a binding activity for cellular surface structures, and component B carries a protease or derivatives thereof as an effector function.

Abstract: A barbeque grill assembly comprises a grill, a frame supporting the grill, a heating element, and a fuel storage tank. A shell receives the fuel storage tank and may have a weight scale to read the fullness of the tank. The shell also offers features such as light and barbeque grill mounts.