Abstract: The use of P2X4 antagonists for the treatment of dry eye syndrome, more in particular substituted N-phenylacetamide compounds of general formula (I), pharmaceutical compositions and combinations comprising said compounds for use in the treatment or prophylaxis of dry eye syndrome and in particular dry eye, ocular neuropathic pain, ocular trauma and post-operative ocular pain.

Abstract: Substituted N-phenylacetamide compounds of general formula (I), methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases.

Abstract: A communication system for use in a switching module includes a low-side control block coupled to control switching of a low-side switch of the switching module. The low-side control block is further coupled to be referenced with a low-side reference system ground. A high-side control block is coupled to control switching of a high-side switch of the switching module. The high-side control block is further coupled to be referenced with a floating node of the switching module. During steady state operation, the low-side control block is coupled to send signals during each switching cycle to the high-side control block to turn the high-side switch on and off. A status update is communicated from the high-side control block to the low-side control block through a first single-wire communication link.

Abstract: A controller includes an oscillator coupled to a switch to determine a time at which the switch is turned on. The oscillator includes a capacitor, a charging current source and a discharging current source coupled to charge and discharge the capacitor. A time period for the capacitor to charge and discharge between first and second voltage levels is a time period of a switching cycle. A duty cycle mode control circuit is coupled to operate in a first duty control mode in response to a feedback signal being between first and second feedback signal values, operate in a second duty control mode in response to the feedback signal being a between the second and third feedback signal values, and operate in a third duty control mode in response to the feedback signal being between the third and fourth feedback signal values.

Abstract: The present invention relates to N-(tetrazolylaryl) amide compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.

Abstract: The present invention relates to tetrazolyl-containing cyclopropanecarboxamides compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.

Abstract: The present invention relates to carboxylic acid aromatic 1,2-cyclopropylamides of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neurogenic disorder, as a sole agent or in combination with other active ingredients.

Abstract: A controller includes an oscillator coupled to a switch to determine a time at which the switch is turned on. The oscillator includes a capacitor, a charging current source and a discharging current source coupled to charge and discharge the capacitor. A time period for the capacitor to charge and discharge between first and second voltage levels is a time period of a switching cycle. A duty cycle mode control circuit is coupled to operate in a first duty control mode in response to a feedback signal being between first and second feedback signal values, operate in a second duty control mode in response to the feedback signal being a between the second and third feedback signal values, and operate in a third duty control mode in response to the feedback signal being between the third and fourth feedback signal values.

Abstract: A communication system for use in a switching module includes a low-side control block coupled to control switching of a low-side switch of the switching module. The low-side control block is further coupled to be referenced with a low-side reference system ground. A high-side control block is coupled to control switching of a high-side switch of the switching module. The high-side control block is further coupled to be referenced with a floating node of the switching module. During steady state operation, the low-side control block is coupled to send signals during each switching cycle to the high-side control block to turn the high-side switch on and off. A status update is communicated from the high-side control block to the low-side control block through a first single-wire communication link.

Abstract: A method for controlling a power converter switch includes operating the power converter switch in first, second, and third duty cycle control modes in response to a feedback signal representative of an output of the power converter. The first duty cycle control mode includes modulating a peak switch current of the power converter switch in response to the feedback signal, and switching the power converter switch at a substantially fixed first switching frequency value. The second duty cycle control mode includes modulating the switching frequency in response to the feedback signal, and maintaining the peak switch current substantially at a peak switch current threshold value. The third duty cycle control mode includes modulating the peak switch current of the power converter switch in response to the feedback signal, and switching the power converter switch at a substantially fixed second switching frequency value.

Abstract: A communication system for use in a switching module includes a low-side control block coupled to control switching of a low-side switch of the switching module. The low-side control block is further coupled to be referenced with a low-side reference system ground. A high-side control block is coupled to control switching of a high-side switch of the switching module. The high-side control block is further coupled to be referenced with a floating node of the switching module. During steady state operation, the low-side control block is coupled to send signals during each switching cycle to the high-side control block to turn the high-side switch on and off. A status update is communicated from the high-side control block to the low-side control block through a first single-wire communication link.

Abstract: A system for use with a motor includes a system controller and a device coupled to the system controller. The device includes a switching element and a current sense output terminal coupled to the system controller. The current sense terminal is coupled to provide a current signal representative of the current of the switching element.

Abstract: A communication system for use in a switching module includes a low-side control block coupled to control switching of a low-side switch of the switching module. The low-side control block is further coupled to be referenced with a low-side reference system ground. A high-side control block is coupled to control switching of a high-side switch of the switching module. The high-side control block is further coupled to be referenced with a floating node of the switching module. During steady state operation, the low-side control block is coupled to send signals during each switching cycle to the high-side control block to turn the high-side switch on and off. A status update is communicated from the high-side control block to the low-side control block through a first single-wire communication link.

Abstract: What is described are BET protein-inhibitory, in particular BRD4-inhibitory 2,3-benzodiazepines of the general formula (I) in which R1a, R1b, R1c, R2, R3, R4, R5, A and X have the meanings given in the description, intermediates for preparing the compounds according to the invention, pharmaceutical compositions comprising the compounds according to the invention and their prophylactic and therapeutic use for hyperproliferative disorders, in particular for tumor disorders. Also described is the use of BET protein inhibitors for benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, for neurodegenerative disorders, for inflammatory disorders, for atherosclerotic disorders and for the control of male fertility.

Abstract: A method for controlling a power converter switch includes operating the power converter switch in first, second, and third duty cycle control modes in response to a feedback signal representative of an output of the power converter. The first duty cycle control mode includes modulating a peak switch current of the power converter switch in response to the feedback signal, and switching the power converter switch at a substantially fixed first switching frequency value. The second duty cycle control mode includes modulating the switching frequency in response to the feedback signal, and maintaining the peak switch current substantially at a peak switch current threshold value. The third duty cycle control mode includes modulating the peak switch current of the power converter switch in response to the feedback signal, and switching the power converter switch at a substantially fixed second switching frequency value.

Abstract: A method for controlling a power converter switch to regulate power delivered to an output of a power converter includes operating the power converter switch in first, second, and third duty cycle control modes in response to a feedback signal. The first duty cycle control mode includes modulating a peak switch current of the power converter switch in response to the feedback signal, and switching the power converter switch at a substantially fixed first switching frequency value. The second duty cycle control mode includes modulating the switching frequency in response to the feedback signal, and maintaining the peak switch current substantially at a peak switch current threshold value. The third duty cycle control mode includes modulating the peak switch current of the power converter switch in response to the feedback signal, and switching the power converter switch at a substantially fixed second switching frequency value.

Abstract: An interface module for use in a power conversion system includes a first current circuit coupled to a single external programming terminal to conduct a programming current through an external programming circuitry coupled to the single external programming terminal. A current comparator is coupled to the first current circuit to compare a current representative of the programming current with an internal current. A mode select circuit is coupled to the current comparator to generate a select signal to select one of a plurality of modes in response to a comparison of the current representative of the programming current with the internal current by the current comparator. A second current circuit is coupled to the first current circuit and the mode select circuit to generate a reference current in response to the programming current and the select signal from the mode select circuit.

Abstract: An energy storage circuit for use with a power converter includes a base capacitor coupled between an input bus and a ground potential, and an adjust capacitor. A switching device is coupled in series with the adjust capacitor between the input bus and the ground potential. A voltage regulator coupled between a control terminal of the switching device and ground. The voltage regulator has an input coupled to the second internal node, wherein when the power switch is turned on a signal at the second internal node is representative of a fluctuating input voltage. The voltage regulator is activated when the fluctuating input voltage is in a crest region, thereby turning the switching device off and disengaging the adjust capacitor. The voltage regulator is deactivated when the fluctuating input voltage is in a valley region, thereby turning the switching device on and engaging the adjust capacitor.

Abstract: A controller for use in a power converter includes a drive circuit coupled to control switching of a power switch of the power converter to regulate the output of the power converter. A limit sense circuit is coupled to output a limit sense signal in response to a condition of the power converter. The drive circuit is coupled to operate in a first operation mode if there is a no limit condition. The first operation mode includes regulating the output of the power converter with a regulated output voltage and a first maximum output current. The drive circuit is coupled to operate in a second operation mode if there is a limit condition. The second operation mode regulating the output of the power converter with the regulated output voltage and a second maximum output current wherein the second maximum output current is less than the first maximum output current.

Abstract: An interface module for use in a power conversion system includes a first current circuit coupled to a single external programming terminal to conduct a programming current through an external programming circuitry coupled to the single external programming terminal. A current comparator is coupled to the first current circuit to compare a current representative of the programming current with an internal current. A mode select circuit is coupled to the current comparator to generate a select signal to select one of a plurality of modes in response to a comparison of the current representative of the programming current with the internal current by the current comparator. A second current circuit is coupled to the first current circuit and the mode select circuit to generate a reference current in response to the programming current and the select signal from the mode select circuit.