Patents by Inventor Stefan Bleich

Stefan Bleich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Susceptibility to and stratification for monoaminergic antidepressants
    Patent number: 10059996
    Abstract: The present invention relates to a method for predicting the non-response or response to a monoaminergic antidepressant of a patient to be treated with a monoaminergic antidepressant comprising the steps: (i) determining the DNA-methylation status of a brain-derived neurotrophic factor (BDNF)-gene promoter in a sample of said patient; (ii) attributing a hypomethylation of said BDNF-gene promoter to the non-response to a monoaminergic antidepressant of said patient; and (iii) attributing normal methylation or hypermethylation of said BDNF-gene promoter to the response to a monoaminergic antidepressant of said patient. Furthermore, a kit and the use of a kit in said method is disclosed.
    Type: Grant
    Filed: May 8, 2013
    Date of Patent: August 28, 2018
    Assignees: Medizineische Hochschule Hannover, Universitätsmedizin der Johannes-Gutenberg-Universität Mainz
    Inventors: Helge Frieling, André Tadic, Stefan Bleich, Klaus J. Lieb
  • SUSCEPTIBILITY TO AND STRATIFICATION FOR MONOAMINERGIC ANTIDEPRESSANTS
    Publication number: 20150184242
    Abstract: The present invention relates to a method for predicting the non-response or response to a monoaminergic antidepressant of a patient to be treated with a monoaminergic antidepressant comprising the steps: (i) determining the DNA-methylation status of a brain-derived neurotrophic factor (BDNF)-gene promoter in a sample of said patient; (ii) attributing a hypomethylation of said BDNF-gene promoter to the non-response to a monoaminergic antidepressant of said patient; and (iii) attributing normal methylation or hypermethylation of said BDNF-gene promoter to the response to a monoaminergic antidepressant of said patient. Furthermore, a kit and the use of a kit in said method is disclosed.
    Type: Application
    Filed: May 8, 2013
    Publication date: July 2, 2015
    Applicant: UNIVERSITASMEDIZN DER JOHANNES-GUTENBERG UNIVERSITAT MAINZ
    Inventors: Helge Frieling, André Tadic, Stefan Bleich, Klaus J. Lieb