Patents by Inventor Stefan Bornstein

Stefan Bornstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODULAR IMPLANTABLE DEVICE FOR THE MACRO-ENCAPSULATION OF CELLS
    Publication number: 20250064574
    Abstract: A modular implantable device for the macroencapsulation of cells, comprising: —at least one bracket configured for accommodating at least one cell module within the device, at least one oxygen module, and at least one immuno-isolating membrane, wherein the at least one oxygen module is contained within the device in a shell formed by the at least one bracket and the at least one immuno-isolating membrane, optionally together with the at least one cell module.
    Type: Application
    Filed: December 19, 2022
    Publication date: February 27, 2025
    Inventors: Barbara Ludwig, Stefan Bornstein, Carsten Werner, Carolin Heller, Petra Welzel
  • GHRH agonists for islet cell transplantation and function and the treatment of diabetes
    Patent number: 9393271
    Abstract: Disclosed herein are compositions of GHRH agonists and peptides, and methods to treat diabetes. In one embodiment, a method of promoting survival of grafted cells and/or tissues may involve exposing the cells and/or tissues to an effective amount of at least one agonist of GHRH. In some embodiments, the grafted cells and/or tissues may be pancreatic cells. In some embodiments, the grafted cells may be islet cells co-cultured with non-pancreatic cells. In a further embodiment, a method of treating a patient diagnosed with diabetes involves transplanting and/or grafting the islet cells and/or tissues comprising islet cells into a patient, and administering a therapeutically effective amount of at least one agonist of GHRH to the patient. In some embodiments, the islet cells and/or tissues comprising islet cells may be optionally exposed to GHRH and/or at least one agonist of GHRH prior to transplantation into a patient.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: July 19, 2016
    Assignees: University of Miami, The United States of America, Represented by the Department of Veterans Affairs, Dresden University of Technology
    Inventors: Andrew V. Schally, Norman L. Block, Stefan Bornstein, Barbara Ludwig
  • Agonists of growth hormone releasing hormone as effectors for survival and proliferation of pancreatic islets
    Patent number: 8980249
    Abstract: Agonists of growth hormone releasing hormone promote islet graft growth and proliferation in patients. Methods of treating patients comprise the use of these agonists.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: March 17, 2015
    Assignees: University of Miami, Dresden University of Technology
    Inventors: Andrew V. Schally, Barbara Ludwig, Stefan Bornstein, Norman L. Block
  • GHRH AGONISTS FOR ISLET CELL TRANSPLANTATION AND FUNCTION AND THE TREATMENT OF DIABETES
    Publication number: 20140193378
    Abstract: Disclosed herein are compositions of GHRH agonists and peptides, and methods to treat diabetes. In one embodiment, a method of promoting survival of grafted cells and/or tissues may involve exposing the cells and/or tissues to an effective amount of at least one agonist of GHRH. In some embodiments, the grafted cells and/or tissues may be pancreatic cells. In some embodiments, the grafted cells may be islet cells co-cultured with non-pancreatic cells. In a further embodiment, a method of treating a patient diagnosed with diabetes involves transplanting and/or grafting the islet cells and/or tissues comprising islet cells into a patient, and administering a therapeutically effective amount of at least one agonist of GHRH to the patient. In some embodiments, the islet cells and/or tissues comprising islet cells may be optionally exposed to GHRH and/or at least one agonist of GHRH prior to transplantation into a patient.
    Type: Application
    Filed: December 23, 2013
    Publication date: July 10, 2014
    Applicants: UNIVERSITY OF MIAMI, DRESDEN UNIVERSITY OF TECHNOLOGY, U.S.A., REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Andrew V. SCHALLY, Norman L. BLOCK, Stefan BORNSTEIN, Barbara LUDWIG
  • AGONISTS OF GROWTH HORMONE RELEASING HORMONE AS EFFECTORS FOR SURVIVAL AND PROLIFERATION OF PANCREATIC ISLETS
    Publication number: 20130195807
    Abstract: Agonists of growth hormone releasing hormone promote islet graft growth and proliferation in patients. Methods of treating patients comprise the use of these agonists.
    Type: Application
    Filed: June 3, 2011
    Publication date: August 1, 2013
    Inventors: Andrew V. Schally, Barbara Ludwig, Stefan Bornstein, Norman L. Block