Abstract: The invention relates to transdermal therapeutic systems which have the active ingredient nicotine and have particularly high flexibility. This flexibility decisively improves wearer comfort on the skin, since the system is readily capable of adapting to the surface of the skin and its constant movement. Surprisingly, the nicotine TTS of the invention is markedly more flexible than the conventional nicotine TTS products which are leaders in the market, although at least some of those systems are comparably thin.

Abstract: A transdermal therapeutic system embodied as a matrix or reservoir system is characterized by

Abstract: A transdermal therapeutic system (TTS) for administering the active substance oxybutynin, comprising a substantially water vapour-impermeable backing layer (1), at least one pressure-sensitive adhesive matrix layer (2, 3) attached thereto, and a detachable protective film (4), is characterized in that the said matrix layer comprises two phases which are immiscible with each other, namely an inner and an outer phase, with the said inner phase (2) containing the active substance oxybutynin base or oxybutynin hydrochloride and being dispersed in the form of droplets in the outer phase (3), and the said outer phase being a pressure sensitive adhesive prepared on the basis of hydrocarbon polymers or/and silicone polymers.

Abstract: In a process for the production of polysiloxane pressure-sensitive adhesive layers with reduced cold flow by means of coating and drying a one-component polysiloxane pressure-sensitive adhesive solution onto a suitable flat-shaped carrier, a complex of a metal ion of the group consisting of calcium, magnesium, zinc, aluminum, titanium, zirconium or hafnium with a low-molecular organic complex former is added to the organic adhesive solution to be coated, whereby the metal ion is only released from the bond to the complex former under the conditions of heating and/or drying of the adhesive solution.

Abstract: A transdermal therapeutic system embodied as a matrix or reservoir system is characterized by a content of at least one basic- or neutral-reacting pharmaceutical active agent a content of a pressure-sensitive adhesive polymer which possesses as part of its chain acrylic acid or methacrylic acid units, the content of the carboxyl groups, relative to the mean polymer mass, being 0.5 to 10.0% (w/w) and the carboxyl groups being present stoichiometrically at 5 to 100 %, preferably 10 to 50%, in form of alkali salts or alkaline earth salts. Water-binding additives may also be present, for reducing the sensitivity to moisture.

Abstract: A medical pressure sensitive adhesive based on polyacrylates and neutral polyamine salts is characterized in that it has a pressure-sensitive adhesive matrix of two polymer components A and B, with polymer component A being a polyacrylate pressure-sensitive adhesive containing carboxyl groups, the carboxyl groups of which are neutralised; the polymer component B being a neutral polyamine salt obtained by reacting a polyacrylate copolymer containing amino groups with an acid, with the polymer component B being dispersed in the polymer component A, and the two components forming a two-phase system.

Abstract: The invention relates to a TTS with backing layers that guarantee a high wear comfort and that facilitate application in regions of the human body that are subject to great mechanical loads, especially the large joints of the extremities. The inventive backing layers overcome the disadvantages with respect to reduced absorption of the active substance by the skin that are typically associated with such backing layers. The inventive systems are preferably used for the local of systemic administration of anti-inflammatory and pain-relieving active substances.

Abstract: A process for ascertaining the adhesive behaviour of pressure-sensitive adhesive flat materials such as medicinal adhesive tape and, in particular, pressure-sensitive adhesive application systems such as transdermal therapeutic systems (TTS) is characterized in that a flat material (5) with an adhesive layer (6) of a defined coating weight per unit area and of defined quality of the adhesive mass is adhered with predetermined surface pressure and at a predetermined temperature to an elastic carrier film (4) of defined thickness and elasticity, and that said carrier film (4) is clamped into a test cell (21), in the manner of a membrane, between half-shells (1,2) of a test cell (21), and that the carrier film (4) along with the adhered flat material (5) is subjected, in chronologically repeated sequence, to loading and unloading with alternating elastic stretchings by defined loading forces from the side facing away from the flat material, and that a detachment of the adhesive layer, which detachment arises pro

Abstract: A transdermal therapeutic system (TTS) for the delivery of active compounds to or through the skin, having a layer adhering comparatively permanently to the skin, whose outer edges are defined by a contour, is characterized in that at least two sections which are concave relative to the surface are contained in the contour.

Abstract: Active ingredient-containing layered articles or discs which are suitable, in particular, as active ingredient reservoirs for transdermal therapeutic systems are obtained starting from an elongate article having an enveloping surface corresponding to the contour of the layered articles to be produced, and having a cross-sectional constitution corresponding to the internal structure of the layered articles, by layered detachment perpendicular to the axial direction of the elongate article. In the simplest case, this article consists of a uniform active ingredient-containing composition and forms a solid cylinder which is converted into single products perpendicular to the axis with identical spacing to result in circular one-compartment discs identical to one another.