Patents by Inventor Stefan Brust
Stefan Brust has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7803524Abstract: Immunologically active peptides which are derived from a novel immunodeficiency virus which has the designation MVP5180/91 are described. A diagnostic composition containing such a peptide and methods of detecting an antibody against a retrovirus that causes immune deficiency using such diagnostic composition are also described. A kit containing the immunologically active peptides is also described. An immunogen and method of immunizing a mammal against HIV infection using the immunologically active peptides is described. DNA encoding the peptides and methods of detecting nucleic acids encoding HIV viruses are also described.Type: GrantFiled: March 21, 2005Date of Patent: September 28, 2010Assignee: Siemens Healthcare Diagnostics Products GmbHInventors: Stefan Brust, Stefan Knapp, Manfred Gerken, Lutz G. Guertler
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Patent number: 6974866Abstract: A novel HIV type O immunodeficiency virus is disclosed which has the designation MVP-2901/94 and which has been deposited with the European collection of animal Cell Cultures (ECACC) under No. V 950121601. The characteristic antigens which can be obtained from the virus and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the partial DNA and amino acid sequences of the virus.Type: GrantFiled: February 4, 2003Date of Patent: December 13, 2005Assignee: Dade Behring Marburg GmbHInventors: Hans-Peter Hauser, Stefan Knapp, Stefan Brust, Lutz G. Gürtler, Josef Eberle, Lazare Kaptue, Léopold Achenqui Zekeng
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Publication number: 20050271678Abstract: Immunologically active peptides which are derived from a novel immunodeficiency virus which has the designation MVP5180/91 are described. A diagnostic composition containing such a peptide and methods of detecting an antibody against a retrovirus that causes immune deficiency using such diagnostic composition are also described. A kit containing the immunologically active peptides is also described. An immunogen and method of immunizing a mammal against HIV infection using the immunologically active peptides is described. DNA encoding the peptides and methods of detecting nucleic acids encoding HIV viruses are also described.Type: ApplicationFiled: March 21, 2005Publication date: December 8, 2005Applicant: Dade Behring Marburg GmbHInventors: Stefan Brust, Stefan Knapp, Manfred Gerken, Lutz Guertler
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Patent number: 6869608Abstract: Immunologically active peptides which are derived from a novel immunodeficiency virus which has the designation MVP5180/91 are described. A diagnostic containing such a peptide and methods of detecting an antibody against a retrovirus that causes immune deficiency using such diagnostic composition are also described. A kit containing the immunologically active peptides is also described. An immunogen and method of immunizing a mammal against HIV infection using the immunologically active peptides is described. DNA encoding the peptides and methods of detecting nucleic acids encoding HIV viruses are also described.Type: GrantFiled: December 4, 2001Date of Patent: March 22, 2005Assignee: Dade Behring Marburg GmbHInventors: Stefan Brust, Stefan Knapp, Manfred Gerken, Lutz G. Guertler
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Publication number: 20030147917Abstract: A novel immunodeficiency virus is disclosed which has the designation MVP-2901/94 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 95012601. The characteristic antigens which can be obtained from the virus and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the partial DNA and amino acid sequences of the virus.Type: ApplicationFiled: February 4, 2003Publication date: August 7, 2003Inventors: Hans-Peter Hauser, Stefan Knapp, Stefan Brust, Lutz G. Gurtler, Josef Eberle, Lazare Kaptue, Leopold Achenqui Zekeng
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Patent number: 6548635Abstract: A novel HIV type O immunodeficiency virus is disclosed which has the designation MVP-2901/94 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 950121601. The characteristic antigens which can be obtained from the virus and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the partial DNA and amino acid sequences of the virus.Type: GrantFiled: July 6, 2000Date of Patent: April 15, 2003Assignee: Dade Behring Marburg GmbHInventors: Hans-Peter Hauser, Stefan Knapp, Stefan Brust, Lutz G. Gürtler, Josef Eberle, Lazare Kaptue, Léopold Achengui Zekeng
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Publication number: 20020123039Abstract: Immunologically active peptides which are derived from a novel immunodeficiency virus which has the designation MVP5180/91 are described. A diagnostic composition containing such a peptide and methods of detecting an antibody against a retrovirus that causes immune deficiency using such diagnostic composition are also described. A kit containing the immunologically active peptides is also described. An immunogen and method of immunizing a mammal against HIV infection using the immunologically active peptides is described. DNA encoding the peptides and methods of detecting nucleic acids encoding HIV viruses are also described.Type: ApplicationFiled: December 4, 2001Publication date: September 5, 2002Inventors: Stefan Brust, Stefan Knapp, Manfred Gerken, Lutz G. Guertler
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Patent number: 6335158Abstract: The present invention is directed toward nucleic-acid based methodologies for the detection of human immunodeficiency virus (HIV) nucleic acids in a sample. A novel HIV-1 isolate, designated MVP5180/91, was isolated from a West African Cameroonian patient with immunodeficiency. Nucleic acid and amino acid sequence comparisons of this isolate, with other HIV-1 strains of subtypes A-E and HIV-2 isolates, demonstrated that this virus shares only limited homology with other known HIV-1 and -2 isolates. However, this virus does display some genetic relatedness to another Cameroonian isolate designated ANT-70. These viruses form the basis for a new HIV-1 group which has been designated subtype O. An immunologically important epitope, corresponding to amino acids 601-623 of the MVP5180/91 transmembrane envelope glycoprotein, was identified. Labeled nucleic acids can be prepared from the nucleotide sequence encoding this region and employed in standard hybridization assays to detect HIV-1 nucleic acids.Type: GrantFiled: August 10, 1998Date of Patent: January 1, 2002Assignee: Dade Behring Marburg GmbHInventors: Stefan Brust, Stefan Knapp, Manfred Gerken, Lutz G. Guertler
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Publication number: 20010009667Abstract: Immunologically active peptides which are derived from a novel immunodeficiency virus which has the designation MVP5180/91 are described. A diagnostic composition containing such a peptide and methods of detecting an antibody against a retrovirus that causes immune deficiency using such diagnostic composition are also described. A kit containing the immunologically active peptides is also described. An immunogen and method of immunizing a mammal against HIV infection using the immunologically active peptides is described. DNA encoding the peptides and methods of detecting nucleic acids encoding HIV viruses are also described.Type: ApplicationFiled: August 10, 1998Publication date: July 26, 2001Inventors: STEFAN BRUST, STEFAN KNAPP, MANFRED GERKEN, LUTZ G. GUERTLER
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Patent number: 6162631Abstract: A novel immunodeficiency virus is disclosed which has the designation MVP-2901/94 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 95012601. The characteristic antigens which can be obtained from the virus and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the partial DNA and amino acid sequences of the virus.Type: GrantFiled: December 12, 1997Date of Patent: December 19, 2000Assignee: Behringwerke AktiengesellschaftInventors: Hans-Peter Hauser, Stefan Knapp, Stefan Brust, Lutz G. Gurtler, Josef Eberle, Lazare Kaptue, Leopold Achengui Zekeng
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Patent number: 6120990Abstract: The present invention is directed to an immunochemical method for qualitatively or quantitatively detecting an analyte in which a first and a second binding component are contacted with the analyte, followed by detection of the binding of the binding components to the analyte. According to the invention, both of the binding components are prepared recombinantly in the same host using different vectors (V1 and V2) for expressing fusion proteins, with the first binding component being expressed as a fusion protein F1 in vector V1 and the second binding component being expressed as a fusion protein F2 in vector V2. The novel method, which can also be employed for simultaneously determining several analytes, is more sensitive and specific than prior known methods.Type: GrantFiled: June 4, 1998Date of Patent: September 19, 2000Assignee: Dade Behring Marburg GmbHInventors: Stefan Brust, Hans-Peter Hauser, Stefan Knapp, Helmut Peters
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Patent number: 6030770Abstract: The present invention relates to a process for the determination of an analyte, in which a sample optionally containing the analyte to be determined is brought into contact with a first receptor R1, which has a binding affinity for the analyte, immobilized on a solid phase, and a receptor R2, which likewise has a binding affinity for the analyte, is added and in which furthermore the resulting immune complexes are brought into contact with a binding factor which has a binding affinity for the analyte and for a receptor R3 immobilized on the same or a second solid phase and in which the amount of the analyte bound to the first solid phase or, if present, to the second solid phase is detected in a suitable manner.Type: GrantFiled: July 17, 1997Date of Patent: February 29, 2000Assignee: Dade Behring Marburg GmbHInventor: Stefan Brust
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Patent number: 5989806Abstract: The present invention relates to a process for the immunochemical determination of one or more analytes in a sample using an immobilized specific receptor R1, which exhibits interactive bioaffinity with the analyte, and a specific receptor R2, which likewise exhibits interactive bioaffinity with the analyte and which as a rule is labeled. In the novel process, a receptor R3, which possesses one or more than one specific binding site for the analyte, is added and the resulting immune complexes are entirely or partially dissociated, after which they are reassociated and subsequently detected. According to a further embodiment, a receptor R4 is employed in addition to the receptor R3, which receptor R4 possesses an affinity towards R3 and is immobilized on the solid phase, with the resulting immune complexes being entirely or partially dissociated, after which they are reassociated and subsequently detected.Type: GrantFiled: December 17, 1997Date of Patent: November 23, 1999Assignee: Behring Diagnostics GmbHInventor: Stefan Brust
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Patent number: 5914243Abstract: The invention relates to a process for the immunochemical determination of an analyte in a sample by means of a first specific binding partner, where the specific binding partner being immobilized on a support and the extent of the binding of the analyte to the specific binding partner being determined by means of a further specific binding partner which directly or indirectly bears a label, wherein there is additionally added to the process a binding factor, which is not labelled.Type: GrantFiled: May 15, 1995Date of Patent: June 22, 1999Assignee: Behring Diagnostics GmbHInventor: Stefan Brust
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Patent number: 5895811Abstract: The invention relates to an artificial positive control reagents based on antibody conjugates that are used in immunochemical detection methods and to processes for the preparation of these reagents.Type: GrantFiled: June 5, 1995Date of Patent: April 20, 1999Assignee: Behring Diagnostics GmbHInventors: Stefan Brust, Heinz-Juergen Friesen, Guenther Nau, Hans-Erwin Pauly
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Patent number: 5830634Abstract: Immunologically active peptides which are derived from a novel immunodeficiency virus which has the designation MVP5180/91 are described. A diagnostic composition containing such a peptide and methods of detecting an antibody against a retrovirus that causes immune deficiency using such diagnostic composition are also described. A kit containing the immunologically active peptides is also described. An immunogen and method of immunizing a mammal against HIV infection using the immunologically active peptides is described. DNA encoding the peptides and methods of detecting nucleic acids encoding HIV viruses are also described.Type: GrantFiled: February 23, 1995Date of Patent: November 3, 1998Assignee: Dade Behring Marburg GmbHInventors: Stefan Brust, Stefan Knapp, Manfred Gerken, Lutz G. Guertler
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Patent number: 5798205Abstract: A novel HIV type O immunodeficiency virus is disclosed which has the designation MVP-2901/94 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 95012601. The characteristic antigens which can be obtained from the virus and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the partial DNA and amino acid sequences of the virus.Type: GrantFiled: February 16, 1996Date of Patent: August 25, 1998Assignee: Behringwerke AktiengesellschaftInventors: Hans-Peter Hauser, Stefan Knapp, Stefan Brust, Lutz G. Gurtler, Josef Eberle, Lazare Kaptue, Leopold Achenqui Zekeng
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Patent number: 5491218Abstract: The invention relates to artificial positive control reagents based on antibody conjugates that are used in immunochemical detection methods and to processes for the preparation of these reagents.Type: GrantFiled: April 1, 1994Date of Patent: February 13, 1996Assignee: Behringwerke AktiengesellschaftInventors: Stefan Brust, Heinz-Juergen Friesen, Guenther Nau, Hans-Erwin Pauly