Abstract: An apparatus, including: a probe to interface with a surface of a tissue; a light source optically coupled to the probe, the light source directing light of at least 1000 nm into the tissue; a detector optically coupled to the probe, the detector to detect light based on scattering of light from the light source in the tissue, and the detector having a light sensitivity in a range of at least 1000 nm; a processor coupled to the detector, the processor to: receive a signal from the detector corresponding to the detected light from the light source, and determine a blood flow measurement from the region of interest using diffuse correlation spectroscopy based on the signal.

Abstract: The present disclosure provides systems and methods for characterizing and monitoring biological material. In one aspect, a method for characterizing biological material includes acquiring optical data associated with a biological material, and analyzing the optical data to determine optical properties of the biological tissue. The method also includes determining, using the optical properties, phase information corresponding to the biological material, and generating a report characterizing the biological tissue using at least the phase information.

Abstract: The present disclosure provides systems and methods for characterizing and monitoring biological material. In one aspect, a method for characterizing biological material includes acquiring optical data associated with a biological material, and analyzing the optical data to determine optical properties of the biological tissue. The method also includes determining, using the optical properties, phase information corresponding to the biological material, and generating a report characterizing the biological tissue using at least the phase information.

Abstract: There is provided herewith an apparatus, probe, and method for the combination of near-infrared spectroscopy (NIRS) and diffuse correlation spectroscopy (DCS). The apparatus, probe and method allow for the simultaneous detection of NIRS and DCS.

Abstract: An apparatus, including: a probe to interface with a surface of a tissue; a light source optically coupled to the probe, the light source directing light of at least 1000 nm into the tissue; a detector optically coupled to the probe, the detector to detect light based on scattering of light from the light source in the tissue, and the detector having a light sensitivity in a range of at least 1000 nm; a processor coupled to the detector, the processor to: receive a signal from the detector corresponding to the detected light from the light source, and determine a blood flow measurement from the region of interest using diffuse correlation spectroscopy based on the signal.

Abstract: The present disclosure provides systems and methods for characterizing and monitoring biological material. In one aspect, a method for characterizing biological material includes acquiring optical data associated with a biological material, and analyzing the optical data to determine optical properties of the biological tissue. The method also includes determining, using the optical properties, phase information corresponding to the biological material, and generating a report characterizing the biological tissue using at least the phase information.

Abstract: A cancer screening method includes changing a compression state of selected tissue; and obtaining a signal indicative of a response of an optical property of the selected tissue in response to the change in the compression state.

Abstract: Laser speckle microrheology is used to determine a mechanical property of a biological tissue, namely, an elastic modulus. Speckle frames may be acquired by illuminating a coherent light and capturing back-scattered rays in parallel and cross-polarized states with respect to illumination. The speckle frames may be analyzed temporally to obtain diffuse reflectance profiles (DRPs) for the parallel-polarized and cross-polarized states. A scattering characteristic of particles in the biological tissue may be determined based on the DRPs, and a displacement characteristic may be determined based at least in part on a speckle intensity autocorrelation function and the scattering characteristic. A size characteristic of scattering particles may be determined based on the DRP for the parallel polarization state. The mechanical property may be calculated using the displacement and size characteristics.

Abstract: There is provided herewith an apparatus, probe, and method for the combination of near-infrared spectroscopy (NIRS) and diffuse correlation spectroscopy (DCS). The apparatus, probe and method allow for the simultaneous detection of NIRS and DCS.

Abstract: An exemplary apparatus can be provided to determine information regarding a sample(s), which can include, for example an arrangement(s) composed of, at least partially, a particular material in a predetermined area thereof, and including a light facilitating device that can be configured to provide or receive a light radiation(s) to or from the sample(s). The particular material can have a characteristic which can facilitate a sufficient amount of X-ray radiation to pass therethrough so as to generate an X-ray image(s). An X-ray absorption of the material can be at most about 10 times that of a ¼? acrylic plate. The light facilitating device can include a light transmitting configuration which can provide the light radiation(s) to the sample.

Abstract: An exemplary apparatus can be provided to determine information regarding a sample(s), which can include, for example an arrangement(s) composed of, at least partially, a particular material in a predetermined area thereof, and including a light facilitating device that can be configured to provide or receive a light radiation(s) to or from the sample(s). The particular material can have a characteristic which can facilitate a sufficient amount of X-ray radiation to pass therethrough so as to generate an X-ray image(s). An X-ray absorption of the material can be at most about 10 times that of a ¼? acrylic plate. The light facilitating device can include a light transmitting configuration which can provide the light radiation(s) to the sample.

Abstract: A cancer screening method includes changing a compression state of selected tissue; and obtaining a signal indicative of a response of an optical property of the selected tissue in response to the change in the compression state.