Abstract: A grinding-means device, in particular a grinding-disc device or backup-pad device, for arranging at least one grinding means, in particular at least one grinding wheel, on a portable power tool, in particular a grinding machine, includes at least one receiving unit, in particular a grinding disc or backup pad, which is fixable in a thread-free manner on an output unit of the tool and on which at least one grinding means is arranged. The grinding-means device includes at least one securing unit formed separately from the receiving unit and configured to axially fix the receiving unit and/or the grinding means to the output unit of the tool in a tool-free manner, and/or at least to axially fix the grinding means to the receiving unit in a tool-free manner.

Abstract: The present invention provides compounds and compositions containing reduced nicotinamide riboside for use in methods of promoting protective immunity and/or for preventing and/or treating bacterial or viral infections and/or for limiting immune mediated pathology following infection in an individual comprising delivering to the individual in need an effective unit dose form of reduced nicotinamide.

Abstract: The present invention provides compounds and compositions containing reduced nicotinamide riboside for use in methods of prevention and/or treatment of pancreatic disease and/or conditions. In one embodiment of the invention, said compounds and compositions of the invention maintain or improve pancreatic tissue function. In another embodiment of the invention, compounds and compositions of the invention may be used in methods to prevent and/or treat pancreatic diseases and/or conditions such as: acute or chronic pancreatitis; pancreatitis associated with diabetes mellitus, cystic fibrosis, or exocrine pancreatic insufficiency or hereditary pancreatitis; pancreatic cancer; and/or recovery after pancreatic injury or surgery.

Abstract: The present invention provides compounds and compositions containing reduced nicotinamide riboside for use in methods of prevention and/or treatment of cardiovascular disease and/or conditions. In one embodiment of the invention, said compounds and compositions of the invention maintain or improve cardiovascular tissue and cellular function. In another embodiment of the invention, said compounds and compositions of the invention enhance cardiovascular recovery after injury or surgery.

Abstract: The present invention provides compounds and compositions containing reduced nicotinamide riboside for use in methods of prevention and/or treatment of neurological disease and/or conditions. In one embodiment of the invention, said compounds and compositions of the invention maintain or improve brain function, in particular brain energy deficits. In another embodiment of the invention, compounds and compositions of the invention improve neurological recovery and regeneration after injury or surgery. In another embodiment of the invention, compounds and compositions of the invention may be used in methods to prevent and/or treat neurological diseases and/or conditions and/or recovery after injury or surgery.

Abstract: The present invention provides compounds and compositions containing reduced nicotinamide riboside for use in methods of prevention and/or treatment of lung disease and/or conditions. In one embodiment of the invention, said compounds and compositions of the invention improve the lung by maintaining or improving lung function. In another embodiment of the invention, the compounds and compositions of the invention improve lung recovery and regeneration after injury or surgery.

Abstract: A wood drill includes a clamping portion for connecting, for conjoint rotation, to a tool fitting of a portable power tool, and a head portion which is provided with a centering geometry. The clamping portion is formed at a first end, remote from a workpiece, and the head portion is formed at a second end, close to a workpiece, of the wood drill. The clamping portion is connected to the head portion via a shank portion. A maximum outside radius of the head portion is greater than a maximum outside radius of the shank portion. The head portion has at least one main lip with at least two stages for introducing a bore with a predefined inside radius into a workpiece. An outside radius of a main lip base is less than 60%, preferably less than 50%, of an outside radius of the head portion.

Abstract: The present invention provides compounds and compositions containing reduced nicotinamide riboside for use in methods of prevention and/or treatment of liver disease and/or conditions. In one embodiment of the invention, said compounds and compositions of the invention improve liver by maintaining or improving liver function; maintaining or improving hepatocyte function; and improving liver recovery and regeneration after injury, transplantation or surgery. In another embodiment of the invention, compounds and compositions of the invention may be used in methods to prevent and/or treat liver diseases and/or conditions such as: non-alcoholic fatty liver disease (NAFLD), alcoholic fatty liver disease, hepatic steatosis, cirrhosis and/or recovery and regeneration after liver injury, transplantation or surgery.

Abstract: The present invention provides compounds and compositions containing reduced nicotinamide riboside for use in methods of prevention and/or treatment of kidney diseases and conditions. In one embodiment of the invention, said compounds and compositions of the invention improve kidney function by reducing formation of kidney cysts, reducing glomerule dilatation, reducing renal cell apoptosis and preventing increases in blood urea nitrogen. In another embodiment of the invention, compounds and compositions of the invention may be used in methods to prevent and/or treat acute kidney injury (AKI), chronic kidney disease, diabetic nephropathy, focal segmental glomerulosclerosis, nephrotic syndrome, renal fibrosis and kidney cancer.

Abstract: The present invention relates to compositions and methods for preventing or treating skeletal muscle conditions or dis- eases. The present invention also relates to compositions and methods that help to increase NAD+levels in skeletal muscle. Preferably, the present invention relates to compositions and methods that use trigonelline and minerals selected from the group consisting of: calcium, magnesium, sodium and/or potassium for preventing or treating skeletal muscle conditions or diseases. The recipient of the compositions of the invention can be, for example, an elderly individual or an individual with sarcopenia or an individual in need of the compositions and methods of the invention for recovery of skeletal muscles, for example, after exercise, muscle injury or surgery.

Abstract: Compositions consist essentially of trigonelline or consist of trigonelline. The compositions can be used in food or beverage applications, pharmaceutical formulations, or as a dietary supplement. The compositions can be administered to a mammal to treat or prevent a mitochondria-related disease or a condition associated with altered mitochondrial function in an individual in need thereof or at risk thereof. The mitochondria-related disease or condition is selected from the group consisting of deleterious effects of aging, stress (e.g.

Abstract: Compositions consist essentially of trigonelline or consist of trigonelline. The compositions can be used in food or beverage applications, pharmaceutical formulations, or as a dietary supplement. The compositions can be administered to a mammal to promote the increase of intracellular levels of nicotinamide adenine dinucleotide (“NAD+”) in cells and tissues for improving cell and tissue survival or overall cell and tissue health. Preferably, NAD+ biosynthesis is increased in one or more cells of a mammal, for example one or more cells that are part of at least one body part selected from the group consisting of a liver, a kidney, a brain, and a skeletal muscle.

Abstract: The present invention relates to compositions and methods for preventing or treating skeletal muscle conditions or diseases. The present invention also relates to compositions and methods that help to increase levels of NAD+ in skeletal muscle. Preferably, the present invention relates to compositions and methods that use trigonelline, high protein and/or creatine and/or tryptophan for preventing or treating skeletal muscle conditions or diseases. The recipient of the compositions or methods of the invention can be, for example, an elderly individual or an individual with sarcopenia or an individual in need of the compositions and methods of the invention for recovery of skeletal muscles, for example, after exercise, muscle injury or surgery.

Abstract: The present invention relates to compositions and methods for preventing or treating skeletal muscle conditions or diseases. The present invention also relates to compositions and methods that help to increase NAD+ levels in skeletal muscle. Preferably, the present invention relates to compositions and methods that use trigonelline and vitamins selected from the group consisting of: Vitamin D, Vitamin B12, B3, B6, B7, Vitamin C and/or Vitamin E for preventing or treating skeletal muscle conditions or diseases. The recipient of the compositions of the invention can be, for example, an elderly individual or an individual with sarcopenia or an individual in need of the compositions and methods of the invention for recovery of skeletal muscles, for example, after exercise, muscle injury or surgery.

Abstract: The present invention provides compounds and compositions containing reduced nicotinamide riboside for use in methods of prevention and/or treatment of skeletal muscle disease and/or conditions. In one embodiment of the invention, said compounds and compositions of the invention improve skeletal muscle by maintaining or improving muscle function; maintaining or increasing muscle mass; maintaining or improving muscle strength; and improving muscle recovery and regeneration after injury or surgery. In another embodiment of the invention, compounds and compositions of the invention may be used in methods to prevent and/or treat skeletal muscle diseases and/or conditions such as: cachexia or precachexia; sarcopenia, myopathy, dystrophy, and/or recovery after intense exercise, muscle injury or surgery.

Abstract: A tool storage device for storing application tools and/or assembly aids includes at least one plug-in member and at least one storage housing. The plug-in member is configured to retain application tools or assembly aids. The storage housing includes a receiving region for releasably fastening the plug-in member to the storage housing. The plug-in member has a first retaining end connected to the receiving region of the storage housing, and a second retaining end connected to the receiving region of the storage housing, in order to secure the plug-in member in a form-fitting manner with respect to at least a first direction. The plug-in member is connected to the storage housing such that the plug-in member is mounted, in particular clamped in place, firmly, in particular in a play-free manner, in at least a second direction on the storage housing.

Abstract: The invention relates to a method for subsequently altering a decorative surface that is ready for use, including the following steps: providing a material panel with a decorative layer which is ready for use and has a first coloured. decoration and a protective layer with a structured surface. According to the invention, in order to provide a method for subsequently altering a decorative surface that is ready for use, with which the structures can be optically highlighted, without interfering with the mechanical or structural integrity of the decorative surface, a second coloured decoration is applied to the protective layer and unevenly distributed.

Abstract: A tool storage device for storing application tools and/or assembly aids includes at least one plug-in member and at least one storage housing. The plug-in member is configured to retain application tools or assembly aids. The storage housing includes a receiving region for releasably fastening the plug-in member to the storage housing. The plug-in member has a first retaining end connected to the receiving region of the storage housing, and a second retaining end connected to the receiving region of the storage housing, in order to secure the plug-in member in a form-fitting manner with respect to at least a first direction. The plug-in member is connected to the storage housing such that the plug-in member is mounted, in particular clamped in place, firmly, in particular in a play-free manner, in at least a second direction on the storage housing.

Abstract: A grinding-means device, in particular a grinding-disc device or backup-pad device, for arranging at least one grinding means, in particular at least one grinding wheel, on a portable power tool, in particular a grinding machine, includes at least one receiving unit, in particular a grinding disc or backup pad, which is fixable in a thread-free manner on an output unit of the tool and on which at least one grinding means is arranged. The grinding-means device includes at least one securing unit formed separately from the receiving unit and configured to axially fix the receiving unit and/or the grinding means to the output unit of the tool in a tool-free manner, and/or at least to axially fix the grinding means to the receiving unit in a tool-free manner.

Abstract: An abrasive-means holding device for holding an abrasive means includes a holding body that is operable to rotate about a central axis. The holding body has a first side, a second side facing away from the first side, and a vacuuming opening that extends therethrough from the first side to the second side. The holding body also has a group of aspiration cavities that are arranged on the first side and that are fluidically connected to each other by at least one through-hole that connects the aspiration cavities. At least one aspiration cavity forms a vacuuming cavity that is directly fluidically connected to the vacuuming opening and that is configured to vacuum-off dust immediately out of an adjacent aspiration cavity and mediately out of a more distantly adjacent aspiration cavity. The aspiration cavities of the group are arranged in relation to each other along a linear course.