Abstract: The present invention relates to compounds with the ability to stimulate/induce ubiquitination of a target protein/target proteins. The compounds of the present invention may stimulate/induce ubiquitination of a target protein/target proteins; i.e. via degradation of a target protein/target proteins by the cullin-RING ubiquitin ligase (CRL). Such target protein/target proteins may be proteins involved in diseases, like cancer, metabolic disorder, infectious disease and/or neurological disorder. The invention also relates to the compounds and composition for use as medicaments as well as pharmaceutical compositions comprising these compounds. Particularly, the compounds of the present invention may degrade proteins associated with cancer, metabolic disorder, infectious disease and/or neurological disorder.

Abstract: A drive train for a wind-up injection device is described. The drive train includes a torsional energy storage adapted to be loaded or unloaded by a rotatable element, a rotatable user handle, a rotationally driveable expelling mechanism adapted to expel the liquid drug, and a clutch element coupled with the torsional energy storage via the rotatable element and including a ratchet for maintaining the rotatable element at one of a number of discrete angular positions against the torque of the torsional energy storage. The clutch element is adapted to transmit the torque from the user handle to the torsional energy storage, or alternatively from the torsional energy storage to the expelling mechanism. The ratchet is switchable from one position to an adjacent position by a torque transmitted from the user handle to the torsional energy storage. The drive train is adapted to dampen torque peaks visco-elastically and/or visco-frictionally.

Abstract: Various embodiments of the present disclosure relate generally to systems and methods for drone-based systems and methods for capturing a multi-media representation of an entity. In some embodiments, the multi-media representation is digital, or multi-view, or interactive, and/or the combinations thereof. According to particular embodiments, a drone having a camera is controlled or operated to obtain a plurality of images having location information. The plurality of images, including at least a portion of overlapping subject matter, are fused to form multi-view interactive digital media representations.

Abstract: An apparatus includes a processor configured to determine a set of geometric relationships in relation to a set of object representations within a computer aided design model, where each geometric relationship is represented by a number, and is configured to determine a set of intervals within the set of geometric relationships that meet a resolution interval criterion, where each interval is a numerical range that does not include numbers representing the geometric relationships, and is configured to select a set of resolution values. Each resolution value is within one of the intervals according to a resolution setting criterion. The processor is configured to update the CAD model by implementing the set of resolution values, generate instructions for controlling a manufacturing process using the updated CAD model, and output the instructions to a manufacturing system for control of the manufacturing process according to the instructions.

Abstract: A button for a drug delivery device with a reduced operating loudness includes a plate-like button body forming a touch surface, wherein the plate-like button body is coupled by an axial supporting member to a noise-generating interface of the drug delivery device and movable into a longitudinal direction of the drug delivery device, wherein the plate-like button body includes a material composite with at least one first component consisting of a first material and at least one second component consisting of a second material different from the first material, wherein the at least one first component and the at least one second component are coupled via at least one coupling plane that is at least sectionwise slanted or perpendicular to the longitudinal direction. Further, the disclosure describes a button assembly for a drug delivery device which is shock resistant.

Abstract: A compound of general formula I wherein A is selected from the group of an unbranched or branched alky group with 1 to 12 carbon atoms, an —R1—O—R2 group, an —R1—Si(R3R4R5) group, an —R1—O—Si(R3R4R5) group, a —C(O)—O—R9—Si(R3R4R5) group, a —CH(O—R6)(O—R7) group, an —R1—CH(O—R6)(O—R7) group, or an —R1—O—C(O)—O—R8 group; SG is a protective group; R1 is a divalent hydrocarbon residue with 1 to 12 carbon atoms; R2 is a monovalent hydrocarbon residue with 1 to 12 carbon atoms; R3, R4 and R5 each independently are a monovalent hydrocarbon residue with 1 to 12 carbon atoms; R6 and R7 each independently are a monovalent hydrocarbon residue with 1 to 12 carbon atoms; R8 is a monovalent hydrocarbon residue with 1 to 12 carbon atoms; and R9 is a divalent hydrocarbon residue with 1 to 12 carbon atoms.

Abstract: Provided herein are methods of preparing a poloxamer for use in a cell culture medium. Also provided herein are cell culture media containing the poloxamer prepared by the methods herein, as well as methods of using the media for cell culturing and polypeptide production from cells.

Abstract: Luminaire (1) comprising suspension means (3) and a housing (5) with a top wall (7). Said suspension means (3) comprising a hook (9a, b) formed of an elastic wire (11) with a loop portion (15) connected to two remote, oppositely arranged end portions (13a, b) each forming a spindle (17a, b), and two elongated channel elements (19a, b) arranged along a rotation axis (21) and mounted on the top wall (7), with each spindle (17a, b) being snugly fitted in a respective channel element (19a, b). By a mutual misalignment between the spindles (17a, b) and the channel element (19a, b) with respect to the rotation axis (21), the hook (9a, b) is in a low tension state when in a first rotational position (27), and in a high tension state when in further rotational positions (29) and urging the hook (9a, b) to assume the first rotational position (27).

Abstract: A lighting device (1) comprising: a substrate defining a plane; at least one solid-state light source mounted on the substrate, an outer light-transmissive envelope (2), and a light-transmissive wall which is arranged at a circumference of the substrate and which has an extension along and is curved towards an optical axis (A) of the lighting device (1). The light-transmissive wall comprises an edge portion distal to the substrate, which edge portion is adapted to diffuse light from the at least one solid-state light source such that a shadow on the outer light-transmissive envelope (2) is blurred, the shadow being caused by an electrical component mounted on the substrate and blocking light emitted by the at least one solid-state light source.

Abstract: A panel module (100), comprising a first frame (110) arranged in a first plane (P), and at least one optical element (135) elongating along the first plane. The first frame is at least partially hollow and arranged to hold at least a peripheral portion of the at least one optical element. The panel module further comprises a lighting arrangement (130) comprising at least one light-emitting diode, wherein the lighting arrangement is arranged within the first frame and at an edge portion of the at least one optical element. The panel further comprises a driver unit (140) coupled to the lighting arrangement and configured to supply power thereto. The first frame comprises a first space (150) provided behind the at least one optical element in a direction (D) perpendicular to the first plane, wherein the driver unit is arranged within the first space.

Abstract: A lighting device (1) comprising: a substrate defining a plane; at least one solid-state light source mounted on the substrate, an outer light-transmissive envelope (2), and a light-transmissive wall which is arranged at a circumference of the substrate and which has an extension along and is curved towards an optical axis (A) of the lighting device (1). The light-transmissive wall comprises an edge portion distal to the substrate, which edge portion is adapted to diffuse light from the at least one solid-state light source such that a shadow on the outer light-transmissive envelope (2) is blurred, the shadow being caused by an electrical component mounted on the substrate and blocking light emitted by the at least one solid-state light source.

Abstract: Luminaire (1) comprising suspension means (3) and a housing (5) with a top wall (7). Said suspension means (3) comprising a hook (9a, b) formed of an elastic wire (11) with a loop portion (15) connected to two remote, oppositely arranged end portions (13a, b) each forming a spindle (17a, b), and two elongated channel elements (19a, b) arranged along a rotation axis (21) and mounted on the top wall (7), with each spindle (17a, b) being snugly fitted in a respective channel element (19a, b). By a mutual misalignment between the spindles (17a, b) and the channel element (19a, b) with respect to the rotation axis (21), the hook (9a, b) is in a low tension state when in a first rotational position (27), and in a high tension state when in further rotational positions (29) and urging the hook (9a, b) to assume the first rotational position (27).

Abstract: The invention provides a kit of parts, especially for a lighting system with a light generated device hosted in a housing, the kit of parts comprising (i) a cable gland (100) comprising a cable gland body (110) and a sealing nut (120) for the cable gland body (110), wherein the cable gland (100) is configured for hosting an electrical cable (10) over at least part of a cable length (L) of the electrical cable (10), wherein the electrical cable (10) comprises an electrically conductive wire (11), wherein the cable gland (100) has a cable gland length (L2), and (ii) a wire transport element (2000) comprising a wire transport connector facility (2220) for hosting a part of a functional device electrically conductive wire (311), wherein the shape of the wire transport element (2000) is such that the wire transport element (2000) can be transported through the cable gland (100) over at least part of the cable gland length (L2).

Abstract: A system and method for operating a lift mechanism are provide, the lifting mechanism (100, 200) including a first housing component (102, 202) and a second housing component (104, 204), the second housing component including a plurality of legs (132, 232) arranged to stabilize the lifting mechanism against a surface of an object, and a magnet (134, 234) arranged within the second housing component. The lifting mechanism further includes a first coupling shaft (136, 236) arranged between the first housing component and the second housing component the first coupling shaft arranged to allow for two degrees of rotational freedom of the first housing component with respect to the second housing component.

Abstract: A luminaire is disclosed comprising an optical stack (200) transparent to radio waves, the optical stack comprising a first surface (210) including a light exit window (211) and a further surface (220) opposing the first surface, the optical stack including a planar light guide (300) having a first major surface facing or defining the first surface, an opposing second major surface facing or defining the further surface and at least one edge surface (310) extending between said opposing first and second major surfaces; and a frame (700) around the optical stack, the frame carrying at least one light source (100) optically coupled to one or more of said edge surfaces of the light guide, wherein the frame delimits the light exit window and an exposed portion (221) of the further surface opposing the light exit window, said light exit window and the exposed portion delimiting a conduit (230) for said radio waves through the optical stack.

Abstract: The invention provides a luminaire (200) comprising a hollow light transmissive body (210), an LED assembly (100) comprised by the hollow light transmissive body (210), and a first end cap (220) closing the hollow light transmissive body (210) at a first end (211) of the hollow light transmissive body (210) and functionally coupled to the hollow light transmissive body (210); wherein (i) the LED assembly (100) is functionally coupled to a connector part (132); (ii) the first end cap (220) is functionally coupled to a complementary connector part (222), complementary to the connector part (132); and (iii) the LED assembly (100) and the first end cap (220) are associated with each other through the connector parts (132, 222), while allowing a translational movement of the LED assembly (100) along a longitudinal axis (115) relative to the hollow light transmissive body (210).

Abstract: A lighting module assembly (1000) comprising a stack of optical elements (1001), a plurality of elongated arms (1010, 1020, 1030, 1040) forming a frame (1005) for supporting the stack of optical elements (1001), at least one arm (1010) having a cavity (1015) extending in an elongation direction of the arm (1010), and at least one lighting element (1090). The cavity (11015) is arranged for receiving the at least one lighting element (1090) and for directing the light (1006) of the lighting element (1090), in use, to the stack (1001), and each elongated arm (1010, 1020, 1030, 1040) is formed by a first elongated arm part (1011). The stack (1001) comprises a diffuser (1002), a light guide plate (1003), and a reflector (1004). At least one first elongated arm parts (1011) is integrally formed with at least one of the diffuser (1002), and the light guide plate (1003).

Abstract: The invention provides a lighting module (100) for use in a luminaire (200). The lighting module comprises a base (101) having a longitudinal axis (LA) which comprises an electrical connector (102) for connecting the lighting module (100) to a luminaire socket (201) of the luminaire (200). The lighting module (100) further comprises a driver unit (103) which comprises a driver circuit (104) which is electrically connected to the electrical connector (102). The lighting module (100) further comprises a light unit (105) which comprises at least one solid state light source (106) which is electrically connected to the driver circuit (104) and emits light. The lighting module (100) further comprises a heat sink (107) which removes heat from the at least one solid state light source (106).

Abstract: A luminaire is disclosed comprising an optical stack (200) transparent to radio waves, the optical stack comprising a first surface (210) including a light exit window (211) and a further surface (220) opposing the first surface, the optical stack including a planar light guide (300) having a first major surface facing or defining the first surface, an opposing second major surface facing or defining the further surface and at least one edge surface (310) extending between said opposing first and second major surfaces; and a frame (700) around the optical stack, the frame carrying at least one light source (100) optically coupled to one or more of said edge surfaces of the light guide, wherein the frame delimits the light exit window and an exposed portion (221) of the further surface opposing the light exit window, said light exit window and the exposed portion delimiting a conduit (230) for said radio waves through the optical stack.

Abstract: The invention provides a kit of parts, especially for a lighting system with a light generated device hosted in a housing, the kit of parts comprising (i) a cable gland (100) comprising a cable gland body (110) and a sealing nut (120) for the cable gland body (110), wherein the cable gland (100) is configured for hosting an electrical cable (10) over at least part of a cable length (L) of the electrical cable (10), wherein the electrical cable (10) comprises an electrically conductive wire (11), wherein the cable gland (100) has a cable gland length (L2), and (ii) a wire transport element (2000) comprising a wire transport connector facility (2220) for hosting a part of a functional device electrically conductive wire (311), wherein the shape of the wire transport element (2000) is such that the wire transport element (2000) can be transported through the cable gland (100) over at least part of the cable gland length (L2).