Patents by Inventor Stefan Dengl

Stefan Dengl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-PD1 ANTIBODIES AND METHODS OF USE
    Publication number: 20170247454
    Abstract: The present invention relates to anti-PD1 antibodies and methods of using the same.
    Type: Application
    Filed: September 29, 2016
    Publication date: August 31, 2017
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Joerg Benz, Laura Codarri Deak, Stefan Dengl, Sebastian Fenn, Jens Fischer, Guy Georges, Christian Klein, Viktor Levitski, Valeria Lifke, Oliver Ploettner, Stefan Seeber, Barbara Weiser, Ildiko Wuensche, Adrian Zwick
  • ANTI-PDGF-B ANTIBODIES AND METHODS OF USE
    Publication number: 20170247440
    Abstract: Herein are reported anti-PDGF-B antibodies and their use in ophthalmology.
    Type: Application
    Filed: May 9, 2017
    Publication date: August 31, 2017
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Marc Bedoucha, Sebastian Breuer, Stefan Dengl, Christian Gassner, Guy Georges, Sabine Gruener, Guido Hartmann, Peter Michael Huelsmann, Joerg Moelleken, Olaf Mundigl, Joerg Thomas Regula, Barbara Weiser
  • BISPECIFIC ANTIBODIES AND METHODS OF USE IN OPHTHALMOLOGY
    Publication number: 20170240629
    Abstract: Herein are reported novel bispecific antibodies that specifically bind to two different antigens selected from the group consisting of human ANG2, human VEGF, human IL-1beta and human PDGF-B.
    Type: Application
    Filed: May 9, 2017
    Publication date: August 24, 2017
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Marc Bedoucha, Sebastian Breuer, Stefan Dengl, Christian Gassner, Guy Georges, Sabine Gruener, Guido Hartmann, Peter Michael Huelsmann, Hubert Kettenberger, Joerg Moelleken, Michael Molhoj, Olaf Mundigl, Joerg Thomas Regula, Ralf Schumacher, Barbara Weiser
  • HER3/HER2 BISPECIFIC ANTIBODIES BINDING TO THE BETA-HAIRPIN OF HER3 AND DOMAIN II OF HER2
    Publication number: 20170233490
    Abstract: The invention relates to HER3/HER2 bispecific antibodies binding to the beta-hairpin of HER3 and domain II of HER2, their preparation and use as medicament.
    Type: Application
    Filed: November 10, 2016
    Publication date: August 17, 2017
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Birgit Bossenmaier, Richard Buick, Stefan Dengl, Michael Gerg, Carmen Peess, Wolfgang Schaefer, Michael Schraeml, Claudio Sustmann
  • COVALENTLY LINKED HELICAR-ANTI-HELICAR ANTIBODY CONJUGATES AND USES THEREOF
    Publication number: 20170058050
    Abstract: Herein is reported a conjugate comprising a helicar motif amino acid sequence containing compound and an antibody that specifically binds to the helicar motif amino acid sequence characterized by a covalent bond between the helicar motif amino acid sequence containing compound and an amino acid residue in the CDR2 of the anti-helicar antibody, whereby the CDR2 is determined according to Kabat.
    Type: Application
    Filed: July 1, 2016
    Publication date: March 2, 2017
    Applicant: Hoffmann-La Roche Inc.
    Inventors: ULRICH BRINKMANN, GUY GEORGES, EIKE HOFFMANN, GEORG TIEFENTHALER, EKKEHARD MOESSNER, STEFAN DENGL, ACHIM GAERTNER
  • COVALENTLY LINKED POLYPEPTIDE TOXIN-ANTIBODY CONJUGATES
    Publication number: 20170058051
    Abstract: Herein is reported a conjugate of a haptenylated polypeptide toxin and an anti-hapten antibody, wherein a disulfide bond is formed between a cysteine residue either before or after the lysine residue that is used for hapten-conjugation and a cysteine residue in the CDR2 of the antibody, whereby the CDR2 is determined according to Kabat.
    Type: Application
    Filed: July 1, 2016
    Publication date: March 2, 2017
    Applicant: Hoffmann-La Roche Inc.
    Inventors: ULRICH BRINKMANN, EIKE HOFFMANN, STEFAN DENGL, KLAUS MAYER
  • HUMANIZED ANTI-TAU(pS422) ANTIBODIES AND METHODS OF USE
    Publication number: 20160376352
    Abstract: The invention provides humanized anti-human Tau(pS422) antibodies and methods of using the same.
    Type: Application
    Filed: June 22, 2016
    Publication date: December 29, 2016
    Inventors: Stefan Dengl, Thomas Emrich, Guy Georges, Ulrich Goepfert, Fiona Grueninger, Adrian Hugenmatter, Anton Jochner, Hubert Kettenberger, Joerg Moelleken, Ekkehard Moessner, Olaf Mundigl, Jens Niewoehner, Tilman Schlothauer, Michael Molhoj, Kevin Brady
  • COVALENTLY LINKED ANTIGEN-ANTIBODY CONJUGATES
    Publication number: 20150258209
    Abstract: Herein is reported a conjugate comprising an antigen and an antibody that specifically binds to the antigen wherein a covalent bond is formed between the antigen and an amino acid residue in the CDR2 of the antibody, an antibody comprising a cysteine residue at amino acid position 53 (according to Kabat) in the heavy chain CDR2 and uses thereof.
    Type: Application
    Filed: December 19, 2014
    Publication date: September 17, 2015
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: JOERG BENZ, ULRICH BRINKMANN, STEFAN DENGL, SEBASTIAN DZIADEK, GUY GEORGES, MICHAEL GROTE, ALEXANDER HAAS, EIKE HOFFMANN
  • METHOD FOR PRODUCING MONOMERIC AND MULTIMERIC MOLECULES AND USES THEREOF
    Publication number: 20150218250
    Abstract: Herein is reported a method for the production of a polypeptide that is biologically active as n-mer comprising a nucleic acid encoding a fusion polypeptide according to the following formula (Bn—CSo—Is—CSp—FC—CSq—It—CSr—Bm)u, wherein B denotes a polypeptide that is biologically active as n-mer and forms non-defined aggregates/multimers upon expression in the absence of a fused Fc-region, FC denotes a heavy chain Fc-region polypeptide, CS denotes a cleavage site, and I denotes an intervening amino acid sequence, wherein FC does not substantially bind to an Fc-receptor, recovering the fusion polypeptide from the cell or the cultivation medium, optionally cleaving the fusion polypeptide with a protease, and thereby producing a polypeptide that is biologically active as n-mer and forms non-defined aggregates/multimers upon expression in the absence of a fused Fc-region.
    Type: Application
    Filed: February 2, 2015
    Publication date: August 6, 2015
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Johannes Auer, Martin Bader, Stefan Dengl, Stefan Lorenz, Stefan Seeber