Patents by Inventor Stefan Dickopf
Stefan Dickopf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7955638Abstract: The present invention relates to binding surfaces for the immobilization of ligands, ligand surfaces and structured surface arrays which present a plurality of identical or different ligands. The invention further relates to a process for the production and the use of such surfaces and to specific binder molecules which can be used for the preparation thereof.Type: GrantFiled: October 30, 2007Date of Patent: June 7, 2011Assignee: Graffinity Pharmaceuticals AGInventors: Stefan Dickopf, Holger Ottleben, Harald Rau, Renate Sekul, Kristina Schmidt, Dirk Vetter
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Patent number: 7842242Abstract: A device for optically coupling a first optical element to a second optical element comprises a first optical element with a first radiation penetration surface; a second optical element with a second radiation penetration surface located across from the first radiation penetration surface; and a chamber delimited by the first and second radiation penetration surfaces and a circumferentially closed side wall which connects the first and second radiation penetration surfaces. The circumferentially closed side wall defines a first sector in the first radiation penetration surface and a second sector in the second radiation penetration surface, the area of the first sector being smaller than the area of the first radiation penetration surface, and the area of the second sector being smaller than the area of the second radiation penetration surface.Type: GrantFiled: April 1, 2004Date of Patent: November 30, 2010Assignee: Graffinity Pharmaceuticals AGInventors: Stefan Dickopf, Thomas Perschke, Mladen Nedic, Kristina Schmidt
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Publication number: 20080167196Abstract: The present invention relates to binding surfaces for the immobilization of ligands, ligand surfaces and structured surface arrays which present a plurality of identical or different ligands. The invention further relates to a process for the production and the use of such surfaces and to specific binder molecules which can be used for the preparation thereof.Type: ApplicationFiled: October 30, 2007Publication date: July 10, 2008Inventors: Stefan Dickopf, Holger Ottleben, Harald Rau, Renate Sekul, Kristina Schmidt, Dirk Vetter
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Publication number: 20070273883Abstract: The invention relates to a sensor arrangement comprising a radiation-conducting substrate, said arrangement having a plurality of sensor fields and separating regions for separating the individual sensor fields from the respectively adjacent sensor fields. Said separating regions are formed by a separating agent layer that causes a reflectivity lower than 0.5 for radiation from the substrate on the interface between the separating agent layer and the substrate, at least in a first region adjacent to the interface between the separating agent layer and the substrate, and an extinction higher than 0.95 at least in a second region located above the first region, on the side opposing the substrate.Type: ApplicationFiled: June 21, 2004Publication date: November 29, 2007Applicant: Graffinity Pharmaceuticals AGInventors: Stefan Dickopf, Klaus Burkert, Alexander Maier, Kristina Schmidt
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Publication number: 20070248300Abstract: A device for optically coupling a first optical element to a second optical element comprises a first optical element with a first radiation penetration surface; a second optical element with a second radiation penetration surface located across from the first radiation penetration surface; and a chamber delimited by the first and second radiation penetration surfaces and a circumferentially closed side wall which connects the first and second radiation penetration surfaces. The circumferentially closed side wall defines a first sector in the first radiation penetration surface and a second sector in the second radiation penetration surface, the area of the first sector being smaller than the area of the first radiation penetration surface, and the area of the second sector being smaller than the area of the second radiation penetration surface.Type: ApplicationFiled: April 1, 2004Publication date: October 25, 2007Applicant: Graffinity Pharmaceuticals AGInventors: Stefan Dickopf, Thomas Perschke, Mladen Nedic, Kristina Schmidt
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Publication number: 20050014135Abstract: The invention relates to a method for the selection and identification of at least on representative (interaction partner) from a plurality of peptide or protein molecules, which can specifically interact with at least one representative from a plurality of target molecules, forming a bond.Type: ApplicationFiled: May 27, 2004Publication date: January 20, 2005Inventors: Oliver Hill, Holger Ottleben, Stefan Dickopf, Klaus Burkert
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Publication number: 20040263853Abstract: The invention relates to a surface plasmon resonance (SPR) sensor surface support comprising a multitude of SPR sensor surfaces that are parallelly arranged in a plane on a substrate. Radiation for exciting surface plasmons can be directed through the substrate in order to be reflected by the SPR sensor surfaces. The sensor surface support also comprises separating means for separating the individual SPR sensor surfaces from the respectively adjacent SPR sensor areas, whereby the separating means for each SPR sensor surface form a respective cavity.Type: ApplicationFiled: May 27, 2004Publication date: December 30, 2004Inventors: Oliver Hill, Klaus Burkert, Stefan Dickopf
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Publication number: 20040235146Abstract: The present invention relates to binding surfaces for the immobilization of ligands, ligand surfaces and structured surface arrays which present a plurality of identical or different ligands. The invention further relates to a process for the production and the use of such surfaces and to specific binder molecules which can be used for the preparation thereof.Type: ApplicationFiled: June 30, 2003Publication date: November 25, 2004Inventors: Stefan Dickopf, Holger Ottleben, Harald Rau, Renate Sekul, Kristina Schmidt, Dirk Vetter
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Patent number: 6795192Abstract: The invention relates to an an SPR surface plasmon resonance spectroscopy sensor for parallel measurement of a plurality of samples, comprising a body (1a) having several SPR sensor areas (2) for guiding radiation in order to carry out SPR measurements and which are coated with a material which is suitable for SPR in such a way that each SPR sensor area (2) can be exclusively associated with a single sample. The radiation conducting body (1a) forms a unit with the SPR sensor areas (2), whereby the path of the rays guided by the SPR sensor areas (2) can also extend through the radiation conducting body (1a).Type: GrantFiled: August 19, 2002Date of Patent: September 21, 2004Assignee: Graffinity Pharmaceutical Design GmbHInventors: Stefan Dickopf, Kristina Schmidt, Dirk Vetter
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Publication number: 20040131510Abstract: The present invention relates to a synthesis apparatus, especially for use in combinatorial chemistry (e.g., solid phase synthesis) as well as a method of manufacturing the same. The synthesis apparatus according to the present invention comprises essentially a vessel, e.g., a microtiterplate, with wall and/or bottom sections as well as a solid phase support, e.g., membranes, which are suitable for use in solid phase synthesis. By thermal effects in an area, preferably a very limited area, of the solid phase support the support is fixed to at least one section of the vessel.Type: ApplicationFiled: February 17, 2004Publication date: July 8, 2004Inventors: Harald Rau, Michael Frank, Kristina Schmidt, Stefan Dickopf, Klaus Burkert
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Patent number: 6752963Abstract: The invention relates to an SPR sensor array comprising a plurality of SPR sensor surface areas (120) arranged on a substrate (10, 20) in a two-dimensional matrix located in a plane to which the SPR sensor surface areas (120) are parallel and whereby radiation capable of exciting surface plasmons in the SPR sensor surface areas (120) under specific physical conditions can be guided through the substrate (10, 20) to be reflected from the SPR sensor surface areas, as well as separating means (110) for separating each SPR sensor surface area (120) from its neighboring SPR sensor surface area (120), wherein the separating means (110) and SPR sensor surface areas (120) are provided such that at least outside of surface plasmon resonance occurring in the SPR sensor surface areas (120) the radiation (40) guided through the substrate (10, 20) is reflected in the region of the separating means to a different degree than in the region of the SPR sensor surface areas (120) to create a contrast between the separating meaType: GrantFiled: February 21, 2001Date of Patent: June 22, 2004Assignee: Graffinity Pharmaceutical Design GmbHInventors: Stefan Dickopf, Kristina Schmidt, Dirk Vetter, Klaus Burkert
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Publication number: 20040023366Abstract: The present invention relates to binding surfaces for the immobilization of ligands, ligand surfaces and structured surface arrays which present a plurality of identical or different ligands. The invention further relates to a process for the production and the use of such surfaces and to specific binder molecules which can be used for the preparation thereof.Type: ApplicationFiled: June 30, 2003Publication date: February 5, 2004Inventors: Stefan Dickopf, Holger Ottleben, Harald Rau, Renate Sekul, Kristina Schmidt, Dirk Vetter
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Publication number: 20030128364Abstract: The invention relates to an an SPR surface plasmon resonance spectroscopy sensor for parallel measurement of a plurality of samples, comprising a body (1a) having several SPR sensor areas (2) for guiding radiation in order to carry out SPR measurements and which are coated with a material which is suitable for SPR in such a way that each SPR sensor area (2) can be exclusively associated with a single sample. The radiation conducting body (1a) forms a unit with the SPR sensor areas (2), whereby the path of the rays guided by the SPR sensor areas (2) can also extend through the radiation conducting body (1a).Type: ApplicationFiled: August 19, 2002Publication date: July 10, 2003Inventors: Stefan Dickopf, Kristina Schmidt, Dirk Vetter
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Patent number: 6441906Abstract: The invention relates to a set-up of measuring instruments for the parallel readout of SPR sensors. The aim of the invention is to provide a measuring arrangement for the parallel readout of a plurality of SPR sensors, wherein the readout process should be terminated within an integration period of less than 30 minutes. To this end, a wavelength-selective component (5) and an optical imaging system (L2, L3) are arranged downstream of a light source (3).Type: GrantFiled: May 18, 2001Date of Patent: August 27, 2002Assignee: Graffinity Pharmaceutical Design GmbHInventors: Stefan Dickopf, Kristina Schmidt, Dirk Vetter
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Publication number: 20020001085Abstract: The invention relates to a set-up of measuring instruments for the parallel readout of SPR sensors. The aim of the invention is to provide a measuring arrangement for the parallel readout of a plurality of SPR sensors, wherein the readout process should be terminated within an integration period of less than 30 minutes. To this end, a wavelength-selective component (5) and an optical imaging system (L2, L3) are arranged downstream of a light source (3).Type: ApplicationFiled: May 18, 2001Publication date: January 3, 2002Inventors: Stefan Dickopf, Kristina Schmidt, Dirk Vetter
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Publication number: 20010026943Abstract: The invention relates to an SPR sensor array comprising a plurality of SPR sensor surface areas (120) arranged on a substrate (10, 20) in a two-dimensional matrix located in a plane to which the SPR sensor surface areas (120) are parallel and whereby radiation capable of exciting surface plasmons in the SPR sensor surface areas (120) under specific physical conditions can be guided through the substrate (10, 20) to be reflected from the SPR sensor surface areas, as well as separating means (110) for separating each SPR sensor surface area (120) from its neighboring SPR sensor surface area (120), wherein the separating means (110) and SPR sensor surface areas (120) are provided such that at least outside of surface plasmon resonance occurring in the SPR sensor surface areas (120) the radiation (40) guided through the substrate (10, 20) is reflected in the region of the separating means to a different degree than in the region of the SPR sensor surface areas (120) to create a contrast between the separating meaType: ApplicationFiled: February 21, 2001Publication date: October 4, 2001Inventors: Stefan Dickopf, Kristina Schmidt, Dirk Vetter, Klaus Burkert