Patents by Inventor Stefan Endres

Stefan Endres has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11355945
    Abstract: A compensation device (20) for compensating for a discharge current has a compensation current generation device (28), a potential generation device (150), active conductor terminals (61, 62, 63, 64) and a PE conductor terminal (65), which active conductor terminals (61, 62, 63, 64) have a first active conductor terminal (61) and a second active conductor terminal (62; 64), which potential generation device (150) is interconnected with the first active conductor terminal (61) and has a potential generation device terminal (155), which potential generation device (150) is designed to provide a potential at the potential generation device terminal (155) which at least temporarily differs from the potential at the first active conductor terminal (61), and which compensation current generation device (28) is designed to effect a compensation current (I_COMP) between the potential generation device terminal (155) and the PE conductor terminal (65).
    Type: Grant
    Filed: January 26, 2021
    Date of Patent: June 7, 2022
    Inventors: Daniel Spesser, Tim Pfizenmaier, Florian Mayer, Stefan Endres, Christoph Sessler
  • Publication number: 20220169699
    Abstract: The present invention relates to PD-1-CD28 fusion proteins, nucleic acid molecules, vectors, transduced cells carrying nucleic acid molecules or vectors of the present invention or expressing the fusion proteins of the present invention, methods and kits comprising the nucleic acid molecules, vectors and/or the fusion proteins of the present invention. The invention also provides the use of said transduced cells in a method for the treatment of particular diseases as well as a pharmaceutical composition/medicament comprising said transduced cells expressing the fusion proteins of the present invention for use in a method of treating of diseases, in particular in the medical intervention of diseases characterized by PD-L1 and/or PD-L2 expression.
    Type: Application
    Filed: October 29, 2021
    Publication date: June 2, 2022
    Inventors: Sebastian Kobold, Stefan Endres
  • Publication number: 20220143087
    Abstract: The present invention relates to lymphocytes genetically engineered to express a CCR8 polypeptide or a functional variant thereof for use in targeted tumor immunotherapies such as adoptive T cell therapy.
    Type: Application
    Filed: March 6, 2020
    Publication date: May 12, 2022
    Inventors: Sebastian Kobold, Stefan Endres, Bruno Cadilha
  • Patent number: 11283366
    Abstract: A rectifier arrangement (20) for rectifying an AC voltage into a DC voltage has a first connection (21), a second connection (22), a third connection (23) and a fourth connection (24), which rectifier arrangement (20) has an intermediate circuit (50) with a first line (51), a second line (52) and a node point (53), which node point (53) is connected to the first line (51) via at least one first capacitor (61) and to the second line (52) via at least one second capacitor (62), which first connection (21), second connection (22) and third connection (23) are each connected to a star point (40) via an associated circuit arrangement (31, 32, 33), which fourth connection (24) is likewise connected to the star point (40), and which star point (40) is connected to the node point (53) via a controllable switch (45).
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: March 22, 2022
    Assignee: Dr. Ing. h. c. F Porsche Aktiengesllschaft
    Inventors: Daniel Spesser, Tim Pfizenmaier, Stefan Endres, Christoph Sessler
  • Publication number: 20220029596
    Abstract: A DC filter device includes: a first filter device connection; a second filter device connection; a third filter device connection; a fourth filter device connection; a coil core; at least one first coil arranged on the coil core, the at least one first coil being connected in between the first filter device connection and the third filter device connection; at least one second coil arranged on the coil core, the at least one second coil being connected in between the second filter device connection and the fourth filter device connection; and a third coil arranged on the coil core, the third coil having a first coil connection and a second coil connection. The first coil connection and the second coil connection are connected to one another via a circuit device, which circuit device has a resistor.
    Type: Application
    Filed: July 19, 2021
    Publication date: January 27, 2022
    Inventors: Daniel Spesser, Tim Pfizenmaier, Stefan Endres
  • Publication number: 20220029552
    Abstract: A rectifier arrangement (20) for rectifying an AC voltage into a DC voltage has connections, circuit arrangements, an interconnection apparatus (26) and an intermediate circuit (50). The connections include first and second connections (22, 21). The intermediate circuit (50) has a first line (51), a second line (52) and at least one capacitor (61, 62) between the first and second lines (51, 52). The circuit arrangements (31, 32, 33, 34, 35, 36) each have a first circuit arrangement connection (A) and a second circuit arrangement connection (B), between which a changeover arrangement (92) and a coil (91) are connected in series. The interconnection apparatus (26) enables at least: a first configuration in which the first connection (22) is connected to at least one first circuit arrangement connection (A), and a second configuration in which the first connection (22) is connected to at least one second circuit arrangement connection (B).
    Type: Application
    Filed: July 21, 2021
    Publication date: January 27, 2022
    Inventors: Daniel Spesser, Tim Pfizenmaier, Florian Mayer, Stefan Endres
  • Publication number: 20220029554
    Abstract: A rectifier arrangement for rectifying an AC voltage into a DC voltage has connections, circuit arrangements, an interconnection apparatus and an intermediate circuit. Each circuit arrangement has first and second circuit arrangement connections, between which a changeover arrangement and a coil are connected in series with the changeover arrangement. The changeover arrangements are interconnected to the intermediate circuit. The interconnection apparatus is designed to enable at least a first configuration and a second configuration. In the first configuration, the circuit arrangements form a first group and a second group, with two connections connected to the circuit arrangements in the first group, but not to the circuit arrangements in the second group, and two connections are connected to the circuit arrangements in the second group, but not to the circuit arrangements in the first group. In the second configuration, at least one of the connections is connected to all circuit arrangements.
    Type: Application
    Filed: July 21, 2021
    Publication date: January 27, 2022
    Inventors: Daniel Spesser, Tim Pfizenmaier, Florian Mayer, Stefan Endres
  • Patent number: 11228255
    Abstract: A rectifier assembly (20) for rectifying an AC voltage into a DC voltage has at least one first terminal (21, 22, 23), a second terminal (24) and an intermediate circuit (50). The first terminal (21, 22, 23) is connected via a circuit (31, 32, 33) to a neutral point (40), and the second terminal (24) is connected to the neutral point (40). The circuit arrangement (31, 32, 33) has a first branch (81) and a second branch (82) connected in parallel with the first branch (81). Both branches (81, 82) comprise a changeover arrangement (92, 93) and a coil (91, 94) connected in series with the changeover arrangement. The coil (91) in the first branch (81) is on the side of the changeover arrangement (92) averted from the neutral point (40), and the coil (94) in the second branch (82) is on the side facing the neutral point (40).
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: January 18, 2022
    Inventors: Daniel Spesser, Tim Pfizenmaier, Stefan Endres, Christoph Sessler
  • Patent number: 11192935
    Abstract: The present invention relates to PD-1-CD28 fusion proteins, nucleic acid molecules, vectors, transduced cells carrying nucleic acid molecules or vectors of the present invention or expressing the fusion proteins of the present invention, methods and kits comprising the nucleic acid molecules, vectors and/or the fusion proteins of the present invention. The invention also provides the use of said transduced cells in a method for the treatment of particular diseases as well as a pharmaceutical composition/medicament comprising said transduced cells expressing the fusion proteins of the present invention for use in a method of treating of diseases, in particular in the medical intervention of diseases characterized by PD-L1 and/or PD-L2 expression.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: December 7, 2021
    Inventors: Sebastian Kobold, Stefan Endres
  • Patent number: 11190003
    Abstract: A method for controlling a charging apparatus of a vehicle, in particular an electric or hybrid vehicle, wherein the charging apparatus has a charging device including a protection and monitoring device. The vehicle includes a high-voltage on-board power system and an electrical energy storage apparatus connected to the high-voltage on-board power system. The method includes electrically connecting the high-voltage on-board power system to charging connections of an energy supply system by the charging apparatus. The charging connections include a neutral conductor, a protective conductor and at least one phase conductor. A protective conductor resistance is detected between the neutral conductor and the protective conductor by feeding in a test current by the protection and monitoring device. A frequency of the test current is filtered out of the compensation frequency range on a narrowband basis.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: November 30, 2021
    Inventors: Tim Pfizenmaier, Daniel Spesser, Michael Kammer, Florian Habel, Eckhard Broeckmann, Frank Mehling, Michael Guenther Zeyen, Wolfgang Hofheinz, Guenter Uhl, Dietmar Bytzek, Juergen Hetzler, Stefan Zeltner, Stefan Endres, Christoph Sessler
  • Publication number: 20210257848
    Abstract: A compensation device (20) for compensating for a discharge current has a compensation current generation device (28), a potential generation device (150), active conductor terminals (61, 62, 63, 64) and a PE conductor terminal (65), which active conductor terminals (61, 62, 63, 64) have a first active conductor terminal (61) and a second active conductor terminal (62; 64), which potential generation device (150) is interconnected with the first active conductor terminal (61) and has a potential generation device terminal (155), which potential generation device (150) is designed to provide a potential at the potential generation device terminal (155) which at least temporarily differs from the potential at the first active conductor terminal (61), and which compensation current generation device (28) is designed to effect a compensation current (I_COMP) between the potential generation device terminal (155) and the PE conductor terminal (65).
    Type: Application
    Filed: January 26, 2021
    Publication date: August 19, 2021
    Inventors: Daniel Spesser, Tim Pfizenmaier, Florian Mayer, Stefan Endres, Christoph Sessler
  • Publication number: 20200317806
    Abstract: The present invention relates to a bispecific (monoclonal) antibody molecule with a first binding domain binding an \JD antigen on CD8+ T-cells that does not naturally occur in and/or on CD8+ T-cells and a second binding domain binding to a tumor M specific antigen naturally occurring on the surface of a minor cell. The bispecific (monoclonal) antibody molecules are particularly useful in combination with transduced CD8+ T-cells comprising an antigen which does not naturally occur in and/or on CD8+ T-cells and/or a T-cell receptor.
    Type: Application
    Filed: April 2, 2020
    Publication date: October 8, 2020
    Inventors: Carole Bourquin, Raffaella Castoldi, Stefan Endres, Christian Klein, Sebastian Kobold, Gerhard Niederfellner, Claudio Sustmann
  • Publication number: 20200295670
    Abstract: A rectifier assembly (20) for rectifying an AC voltage into a DC voltage has at least one first terminal (21, 22, 23), a second terminal (24) and an intermediate circuit (50). The first terminal (21, 22, 23) is connected via a circuit (31, 32, 33) to a neutral point (40), and the second terminal (24) is connected to the neutral point (40). The circuit arrangement (31, 32, 33) has a first branch (81) and a second branch (82) connected in parallel with the first branch (81). Both branches (81, 82) comprise a changeover arrangement (92, 93) and a coil (91, 94) connected in series with the changeover arrangement. The coil (91) in the first branch (81) is on the side of the changeover arrangement (92) averted from the neutral point (40), and the coil (94) in the second branch (82) is on the side facing the neutral point (40).
    Type: Application
    Filed: March 16, 2020
    Publication date: September 17, 2020
    Inventors: Daniel Spesser, Tim Pfizenmaier, Stefan Endres, Christoph Sessler
  • Patent number: 10633451
    Abstract: The present invention relates to a bispecific (monoclonal) antibody molecule with a first binding domain binding an antigen on CD8+ T-cells that does not naturally occur in and/or on CD8+ T-cells and a second binding domain binding to a tumor specific antigen naturally occurring on the surface of a tumor cell. The bispecific (monoclonal) antibody molecules are particularly useful in combination with transduced CD8+ T-cells comprising an antigen which does not naturally occur in and/or on CD8+ T-cells and/or a T-cell receptor.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: April 28, 2020
    Assignees: Hoffmann-La Roche Inc., Ludwig-Maximillians-Universit√§t M√ľnchen
    Inventors: Carole Bourquin, Raffaella Castoldi, Stefan Endres, Christian Klein, Sebastian Kobold, Gerhard Niederfellner, Claudio Sustmann
  • Publication number: 20190270382
    Abstract: A method for controlling a charging apparatus of a vehicle, in particular an electric or hybrid vehicle, wherein the charging apparatus has a charging device including a protection and monitoring device. The vehicle includes a high-voltage on-board power system and an electrical energy storage apparatus connected to the high-voltage on-board power system. The method includes electrically connecting the high-voltage on-board power system to charging connections of an energy supply system by the charging apparatus. The charging connections include a neutral conductor, a protective conductor and at least one phase conductor. A protective conductor resistance is detected between the neutral conductor and the protective conductor by feeding in a test current by the protection and monitoring device. A frequency of the test current is filtered out of the compensation frequency range on a narrowband basis.
    Type: Application
    Filed: March 4, 2019
    Publication date: September 5, 2019
    Applicant: Dr. Ing. h.c. F. Porsche Aktiengesellschaft
    Inventors: Tim Pfizenmaier, Daniel Spesser, Michael Kammer, Florian Habel, Eckhard Broeckmann, Frank Mehling, Michael Guenther Zeyen, Wolfgang Hofheinz, Guenter Uhl, Dietmar Bytzek, Juergen Hetzler, Stefan Zeltner, Stefan Endres, Christoph Sessler
  • Publication number: 20190216908
    Abstract: The present invention generally relates to T-cells, such as CD8+ T-cells, CD4+ T-cells, CD3+ T-cells, ?? T-cells or natural killer (NK) T-cells, transfected/transduced with a fusion protein which is recruited by the use of trivalent, bispecific antibody molecule which specifically binds to/interacts with the extracellular domain of the fusion protein. More precisely, the present invention relates to a kit comprising the nucleic acid molecules, vectors and/or the fusion proteins of the present invention and the trivalent, bispecific antibody molecules of the present invention. Further aspects of the inventions are expression vectors comprising nucleic acid molecules encoding the fusion proteins as well as the trivalent, bispecific antibody molecules. Further, a process for the production of the trivalent, bispecific antibody molecules of the invention and a medicament/pharmaceutical composition comprising said trivalent, bispecific antibody molecules are described.
    Type: Application
    Filed: June 30, 2017
    Publication date: July 18, 2019
    Inventors: Christian Klein, Claudio Sustmann, Gerhard Niederfellner, Martina Geiger, Stefan Endres, Sebastian Kobold
  • Publication number: 20190010207
    Abstract: The present invention relates to PD-1-CD28 fusion proteins, nucleic acid molecules, vectors, transduced cells carrying nucleic acid molecules or vectors of the present invention or expressing the fusion proteins of the present invention, methods and kits comprising the nucleic acid molecules, vectors and/or the fusion proteins of the present invention. The invention also provides the use of said transduced cells in a method for the treatment of particular diseases as well as a pharmaceutical composition/medicament comprising said transduced cells expressing the fusion proteins of the present invention for use in a method of treating of diseases, in particular in the medical intervention of diseases characterized by PD-L1 and/or PD-L2 expression.
    Type: Application
    Filed: June 20, 2016
    Publication date: January 10, 2019
    Inventors: Sebastian KOBOLD, Stefan ENDRES
  • Publication number: 20180256645
    Abstract: The present invention relates to CXCR6-transduced (a) T cell(s) such as (a) CD8+ T cell(s), (a) CD4+ T cell(s), (a) CD3+ T cell(s), (a) ?? T cell(s) or (a) natural killer (NK) T cell(s) for targeted tumor therapy, nucleic acid sequences, vectors capable of transducing such (a) T cell(s), (a) transduced T cell(s) carrying the nucleic acid sequences or vectors of the present invention, methods and kits comprising the nucleic acid sequences or vectors of the present invention. The invention also provides the use of said transduced T cell(s) in a method for the treatment of diseases characterized by CXCL16 overexpression as well as a pharmaceutical composition/medicament comprising (a) transduced T cell(s) expressing the CXCR6 for use in methods of treating diseases characterized by CXCL16 overexpression.
    Type: Application
    Filed: October 14, 2016
    Publication date: September 13, 2018
    Inventors: Sebastian KOBOLD, Stefan ENDRES, Moritz RAPP, Simon GRASSMANN
  • Patent number: 9929566
    Abstract: A circuit includes an active element, a drive circuit for the active element and a control logic for providing a control signal for the drive circuit. Further, an interface circuit is provided, which includes a primary terminal for receiving a primary signal and a secondary terminal that is galvanically isolated from the primary terminal. The interface circuit is implemented to provide the primary signal received at the primary terminal to the control logic via the secondary terminal, and to provide, based on the primary signal received at the primary terminal, by means of a rectifier circuit, an auxiliary energy signal for the drive circuit at the secondary terminal.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: March 27, 2018
    Assignee: Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V.
    Inventors: Stefan Zeltner, Stefan Endres
  • Publication number: 20160013655
    Abstract: A circuit includes an active element, a drive circuit for the active element and a control logic for providing a control signal for the drive circuit. Further, an interface circuit is provided, which includes a primary terminal for receiving a primary signal and a secondary terminal that is galvanically isolated from the primary terminal. The interface circuit is implemented to provide the primary signal received at the primary terminal to the control logic via the secondary terminal, and to provide, based on the primary signal received at the primary terminal, by means of a rectifier circuit, an auxiliary energy signal for the drive circuit at the secondary terminal.
    Type: Application
    Filed: September 25, 2015
    Publication date: January 14, 2016
    Inventors: Stefan Zeltner, Stefan Endres