Patents by Inventor Stefan Engelhardt
Stefan Engelhardt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240189339Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.Type: ApplicationFiled: November 21, 2023Publication date: June 13, 2024Applicant: Julius-Maximilians-Universitat WurzburgInventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Publication number: 20230287413Abstract: The present invention relates to a composition for use in the treatment of pulmonary fibrosis of a subject, wherein the composition comprises an inhibitor of miR-21 and a moiety that delivers said inhibitor of miR-21 to a macrophage. Further, the composition may be administered by a pulmonary administration. In particular aspects, said subject to be treated suffers from pulmonary fibrosis and further has a lung disease or disorder, wherein the lung disease or disorder may be a corona virus disease. Furthermore, the invention relates to a composition, wherein the composition comprises an inhibitor of miR-21 and a moiety that delivers said inhibitor of miR-21 to a lung macrophage.Type: ApplicationFiled: April 9, 2021Publication date: September 14, 2023Applicant: Technische Universität MünchenInventors: Stefan ENGELHARDT, Deepak Prabhu RAMANUJAM
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Publication number: 20230028937Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.Type: ApplicationFiled: June 22, 2022Publication date: January 26, 2023Applicant: Julius-Maximilians-Universitat WurzburgInventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Publication number: 20210113603Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.Type: ApplicationFiled: September 1, 2020Publication date: April 22, 2021Applicant: Julius-Maximilians-Universitat WurzburgInventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Patent number: 10915303Abstract: Disclosed herein are system, method, and computer program product embodiments for an integrated development and modification system. An embodiment operates by providing an application including a user interface component bound to perform a function on data from a data source. A modification of the user interface component is received during a run time of the application. The modification is applied to the application. The application including the modification is provided to the user during the run time of the application.Type: GrantFiled: January 26, 2017Date of Patent: February 9, 2021Assignee: SAP SEInventors: Tim Back, Holger Bohle, Stefan Engelhardt, Thorsten Erlewein, Ioannis Grammatikakis, Ralf Handl, Bernhard Siewert, Gregor Tielsch, Marcel Waechter, Martin Zurmuehl, Christoph Gollmick
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Patent number: 10726011Abstract: A system includes reception of a first query to search two or more heterogeneous data providers, generation of a first query language excerpt to define a combined key column based on key columns associated with a first data provider of the two or more heterogeneous data providers, for each of two or more columns of the first data provider, generation of a second query language excerpt to map the column of the first data provider to a respective result set key column and a respective result set value column, generation of a third query language excerpt to identify two or more of the result set value columns to search, and generation of a first query language statement based on the first, second and third query language excerpts.Type: GrantFiled: October 11, 2016Date of Patent: July 28, 2020Assignee: SAP SEInventors: Christian Conradi, Marcel Hermanns, Stefan Engelhardt, Vera Thome-Fix, Maximilian Eisele, Gregor Tielsch
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Publication number: 20200069720Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.Type: ApplicationFiled: August 16, 2019Publication date: March 5, 2020Applicant: Julius-Maximilians-Universitat WurzburgInventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Patent number: 10434117Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.Type: GrantFiled: June 22, 2018Date of Patent: October 8, 2019Assignee: Julius-Maximilians-Universitat WurzburgInventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Publication number: 20180360866Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.Type: ApplicationFiled: June 22, 2018Publication date: December 20, 2018Applicant: Julius-Maximilians-Universitat WurzburgInventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Publication number: 20180210622Abstract: Disclosed herein are system, method, and computer program product embodiments for an integrated development and modification system. An embodiment operates by providing an application including a user interface component bound to perform a function on data from a data source. A modification of the user interface component is received during a run time of the application. The modification is applied to the application. The application including the modification is provided to the user during the run time of the application.Type: ApplicationFiled: January 26, 2017Publication date: July 26, 2018Inventors: Tim Back, Holger Bohle, Stefan Engelhardt, Thorsten Erlewein, Ioannis Grammatikakis, Ralf Handl, Bernhard Siewert, Gregor Tielsch, Marcel Waechter, Martin Zurmuehl, Christoph Gollmick
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Publication number: 20180210717Abstract: Disclosed herein are system, method, and computer program product embodiments for an integrated development and modification system. An embodiment operates by receiving a selection of a user interface component of an application. Metadata corresponding to data of a data source is determined, and a function that executes an operation with respect to the data is determined. One or more roles that have access to the data are determined. The application, including the user interface component, is provided via a web browser for access by a user associated with one of the roles.Type: ApplicationFiled: January 26, 2017Publication date: July 26, 2018Inventors: Tim Back, Holger Bohle, Stefan Engelhardt, Thorsten Erlewein, Ioannis Grammatikakis, Ralf Handl, Bernhard Siewert, Gregor Tielsch, Marcel Waechter, Martin Zurmuehl, Christoph Gollmick
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Patent number: 10028974Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.Type: GrantFiled: April 19, 2017Date of Patent: July 24, 2018Assignee: Julius-Maximilians-Universitat WurzburgInventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Publication number: 20180101572Abstract: A system includes reception of a first query to search two or more heterogeneous data providers, generation of a first query language excerpt to define a combined key column based on key columns associated with a first data provider of the two or more heterogeneous data providers, for each of two or more columns of the first data provider, generation of a second query language excerpt to map the column of the first data provider to a respective result set key column and a respective result set value column, generation of a third query language excerpt to identify two or more of the result set value columns to search, and generation of a first query language statement based on the first, second and third query language excerpts.Type: ApplicationFiled: October 11, 2016Publication date: April 12, 2018Inventors: Christian Conradi, Marcel Hermanns, Stefan Engelhardt, Vera Thome-Fix, Maximilian Eisele, Gregor Tielsch
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Publication number: 20170304347Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.Type: ApplicationFiled: April 19, 2017Publication date: October 26, 2017Applicant: Julius-Maximilians-Universitat WurzburgInventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Patent number: 9663788Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.Type: GrantFiled: November 20, 2015Date of Patent: May 30, 2017Assignee: Julius-Maximilans-Universitat WurzburgInventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Publication number: 20160177302Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.Type: ApplicationFiled: November 20, 2015Publication date: June 23, 2016Inventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Patent number: 9220722Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.Type: GrantFiled: October 23, 2013Date of Patent: December 29, 2015Assignee: JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURGInventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Publication number: 20150369481Abstract: In order to be able to make length adjustments in a chimney pipe system as flexibly as possible, the chimney pipe has two opposite connection ends, which are connected to each other by a center part. The one connection end has a conical insertion region and the other connection end is cylindrical. The cylindrical configuration enables arbitrary trimming on site, without additional measures being required.Type: ApplicationFiled: August 28, 2015Publication date: December 24, 2015Inventor: Stefan ENGELHARDT
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Publication number: 20140121264Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.Type: ApplicationFiled: October 23, 2013Publication date: May 1, 2014Applicant: JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURGInventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Patent number: 8592389Abstract: In some embodiments, the present invention concerns antisense oligonucleotides against targets of miR-21. In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.Type: GrantFiled: June 28, 2012Date of Patent: November 26, 2013Assignee: Julius-Maximilians-Universitat WurzburgInventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross