Patents by Inventor Stefan Engelhardt

Stefan Engelhardt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240189339
    Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.
    Type: Application
    Filed: November 21, 2023
    Publication date: June 13, 2024
    Applicant: Julius-Maximilians-Universitat Wurzburg
    Inventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
  • Publication number: 20230287413
    Abstract: The present invention relates to a composition for use in the treatment of pulmonary fibrosis of a subject, wherein the composition comprises an inhibitor of miR-21 and a moiety that delivers said inhibitor of miR-21 to a macrophage. Further, the composition may be administered by a pulmonary administration. In particular aspects, said subject to be treated suffers from pulmonary fibrosis and further has a lung disease or disorder, wherein the lung disease or disorder may be a corona virus disease. Furthermore, the invention relates to a composition, wherein the composition comprises an inhibitor of miR-21 and a moiety that delivers said inhibitor of miR-21 to a lung macrophage.
    Type: Application
    Filed: April 9, 2021
    Publication date: September 14, 2023
    Applicant: Technische Universität München
    Inventors: Stefan ENGELHARDT, Deepak Prabhu RAMANUJAM
  • Publication number: 20230028937
    Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.
    Type: Application
    Filed: June 22, 2022
    Publication date: January 26, 2023
    Applicant: Julius-Maximilians-Universitat Wurzburg
    Inventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
  • Publication number: 20210113603
    Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.
    Type: Application
    Filed: September 1, 2020
    Publication date: April 22, 2021
    Applicant: Julius-Maximilians-Universitat Wurzburg
    Inventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
  • Patent number: 10915303
    Abstract: Disclosed herein are system, method, and computer program product embodiments for an integrated development and modification system. An embodiment operates by providing an application including a user interface component bound to perform a function on data from a data source. A modification of the user interface component is received during a run time of the application. The modification is applied to the application. The application including the modification is provided to the user during the run time of the application.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: February 9, 2021
    Assignee: SAP SE
    Inventors: Tim Back, Holger Bohle, Stefan Engelhardt, Thorsten Erlewein, Ioannis Grammatikakis, Ralf Handl, Bernhard Siewert, Gregor Tielsch, Marcel Waechter, Martin Zurmuehl, Christoph Gollmick
  • Patent number: 10726011
    Abstract: A system includes reception of a first query to search two or more heterogeneous data providers, generation of a first query language excerpt to define a combined key column based on key columns associated with a first data provider of the two or more heterogeneous data providers, for each of two or more columns of the first data provider, generation of a second query language excerpt to map the column of the first data provider to a respective result set key column and a respective result set value column, generation of a third query language excerpt to identify two or more of the result set value columns to search, and generation of a first query language statement based on the first, second and third query language excerpts.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: July 28, 2020
    Assignee: SAP SE
    Inventors: Christian Conradi, Marcel Hermanns, Stefan Engelhardt, Vera Thome-Fix, Maximilian Eisele, Gregor Tielsch
  • Publication number: 20200069720
    Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.
    Type: Application
    Filed: August 16, 2019
    Publication date: March 5, 2020
    Applicant: Julius-Maximilians-Universitat Wurzburg
    Inventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
  • Patent number: 10434117
    Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: October 8, 2019
    Assignee: Julius-Maximilians-Universitat Wurzburg
    Inventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
  • Publication number: 20180360866
    Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.
    Type: Application
    Filed: June 22, 2018
    Publication date: December 20, 2018
    Applicant: Julius-Maximilians-Universitat Wurzburg
    Inventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
  • Publication number: 20180210622
    Abstract: Disclosed herein are system, method, and computer program product embodiments for an integrated development and modification system. An embodiment operates by providing an application including a user interface component bound to perform a function on data from a data source. A modification of the user interface component is received during a run time of the application. The modification is applied to the application. The application including the modification is provided to the user during the run time of the application.
    Type: Application
    Filed: January 26, 2017
    Publication date: July 26, 2018
    Inventors: Tim Back, Holger Bohle, Stefan Engelhardt, Thorsten Erlewein, Ioannis Grammatikakis, Ralf Handl, Bernhard Siewert, Gregor Tielsch, Marcel Waechter, Martin Zurmuehl, Christoph Gollmick
  • Publication number: 20180210717
    Abstract: Disclosed herein are system, method, and computer program product embodiments for an integrated development and modification system. An embodiment operates by receiving a selection of a user interface component of an application. Metadata corresponding to data of a data source is determined, and a function that executes an operation with respect to the data is determined. One or more roles that have access to the data are determined. The application, including the user interface component, is provided via a web browser for access by a user associated with one of the roles.
    Type: Application
    Filed: January 26, 2017
    Publication date: July 26, 2018
    Inventors: Tim Back, Holger Bohle, Stefan Engelhardt, Thorsten Erlewein, Ioannis Grammatikakis, Ralf Handl, Bernhard Siewert, Gregor Tielsch, Marcel Waechter, Martin Zurmuehl, Christoph Gollmick
  • Patent number: 10028974
    Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: July 24, 2018
    Assignee: Julius-Maximilians-Universitat Wurzburg
    Inventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
  • Publication number: 20180101572
    Abstract: A system includes reception of a first query to search two or more heterogeneous data providers, generation of a first query language excerpt to define a combined key column based on key columns associated with a first data provider of the two or more heterogeneous data providers, for each of two or more columns of the first data provider, generation of a second query language excerpt to map the column of the first data provider to a respective result set key column and a respective result set value column, generation of a third query language excerpt to identify two or more of the result set value columns to search, and generation of a first query language statement based on the first, second and third query language excerpts.
    Type: Application
    Filed: October 11, 2016
    Publication date: April 12, 2018
    Inventors: Christian Conradi, Marcel Hermanns, Stefan Engelhardt, Vera Thome-Fix, Maximilian Eisele, Gregor Tielsch
  • Publication number: 20170304347
    Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.
    Type: Application
    Filed: April 19, 2017
    Publication date: October 26, 2017
    Applicant: Julius-Maximilians-Universitat Wurzburg
    Inventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
  • Patent number: 9663788
    Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: May 30, 2017
    Assignee: Julius-Maximilans-Universitat Wurzburg
    Inventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
  • Publication number: 20160177302
    Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.
    Type: Application
    Filed: November 20, 2015
    Publication date: June 23, 2016
    Inventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
  • Patent number: 9220722
    Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: December 29, 2015
    Assignee: JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
    Inventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
  • Publication number: 20150369481
    Abstract: In order to be able to make length adjustments in a chimney pipe system as flexibly as possible, the chimney pipe has two opposite connection ends, which are connected to each other by a center part. The one connection end has a conical insertion region and the other connection end is cylindrical. The cylindrical configuration enables arbitrary trimming on site, without additional measures being required.
    Type: Application
    Filed: August 28, 2015
    Publication date: December 24, 2015
    Inventor: Stefan ENGELHARDT
  • Publication number: 20140121264
    Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.
    Type: Application
    Filed: October 23, 2013
    Publication date: May 1, 2014
    Applicant: JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
    Inventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
  • Patent number: 8592389
    Abstract: In some embodiments, the present invention concerns antisense oligonucleotides against targets of miR-21. In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: November 26, 2013
    Assignee: Julius-Maximilians-Universitat Wurzburg
    Inventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross