Patents by Inventor Stefan Evers

Stefan Evers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220054635
    Abstract: The present invention relates to methods of treating a disease, and methods for reduction of the formation of anti-drug antibodies (ADAs) in response to the administration of a therapeutic agent. The invention further relates to methods of treating a disease, particularly a B-cell proliferative disorder, and methods for reduction of adverse effects in response to the administration of a therapeutic agent, particularly a T-cell activating therapeutic agent.
    Type: Application
    Filed: November 5, 2021
    Publication date: February 24, 2022
    Inventors: Marina BACAC, Stefan EVERS, Christian KLEIN, Pavel PISA, Eva ROSSMANN, Jose SARO, Pablo UMANA
  • Patent number: 11154485
    Abstract: The invention relates to an antiperspirant cosmetic agent which includes at least one specific chitosan and which is free of aluminum-containing compounds, in particular free of halides and/or hydroxy halides of aluminum and/or zirconium. The present invention further relates to the use of a specific chitosan and to a non-therapeutic method for reducing body perspiration. Adding or using the at least one specific chitosan ensures that the sweat gland(s) is/are effectively influenced, thus resulting in a significant reduction in underarm perspiration even in the absence of antiperspirant aluminum-containing compounds.
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: October 26, 2021
    Assignee: Henkel AG & Co. KGaA
    Inventors: Bernhard Banowski, Stefan Evers, Marcus Claas
  • Publication number: 20210252144
    Abstract: The present invention relates to methods of treating a disease, and methods for reduction of the formation of anti-drug antibodies (ADAs) in response to the administration of a therapeutic agent. The invention further relates to methods of treating a disease, particularly a B-cell proliferative disorder, and methods for reduction of adverse effects in response to the administration of a therapeutic agent, particularly a T-cell activating therapeutic agent.
    Type: Application
    Filed: April 26, 2021
    Publication date: August 19, 2021
    Inventors: Marina BACAC, Stefan EVERS, Christian KLEIN, Pavel PISA, Eva ROSSMANN, Jose SARO, Pablo UMANA
  • Patent number: 11046961
    Abstract: The aim of the invention is to improve the secretion of a protein from a host cell in order to increase the product yield of protein in a fermentation process. This is achieved by an expression vector comprising a) a promoter sequence and b) a nucleic acid sequence that codes for a protein. The protein comprises a signal peptide and an additional amino acid sequence, and the signal peptide comprises an amino acid sequence that is at least 80% identical to the amino acid sequence specified in SEQ ID NO: 2, at least 80% identical to the amino acid sequence specified in SEQ ID NO: 4, at least 80% identical to the amino acid sequence specified in SEQ ID NO: 6, or the signal peptide comprises an amino acid sequence that is structurally homologous to at least one of said sequences.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: June 29, 2021
    Assignee: BASF SE
    Inventors: Christian Degering, Thorsten Eggert, Stefan Evers, Karl-Heinz Maurer, Johannes Bongaerts
  • Patent number: 11013801
    Abstract: The present invention relates to methods of treating a disease, and methods for reduction of the formation of anti-drug antibodies (ADAs) in response to the administration of a therapeutic agent. The invention further relates to methods of treating a disease, particularly a B-cell proliferative disorder, and methods for reduction of adverse effects in response to the administration of a therapeutic agent, particularly a T-cell activating therapeutic agent.
    Type: Grant
    Filed: December 7, 2016
    Date of Patent: May 25, 2021
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Marina Bacac, Stefan Evers, Christian Klein, Pavel Pisa, Eva Rossmann, Jose Saro, Pablo Umana
  • Publication number: 20200095564
    Abstract: The aim of the invention is to improve the secretion of a protein from a host cell in order to increase the product yield of protein in a fermentation process. This is achieved by an expression vector comprising a) a promoter sequence and b) a nucleic acid sequence that codes for a protein. The protein comprises a signal peptide and an additional amino acid sequence, and the signal peptide comprises an amino acid sequence that is at least 80% identical to the amino acid sequence specified in SEQ ID NO: 2, at least 80% identical to the amino acid sequence specified in SEQ ID NO: 4, at least 80% identical to the amino acid sequence specified in SEQ ID NO: 6, or the signal peptide comprises an amino acid sequence that is structurally homologous to at least one of said sequences.
    Type: Application
    Filed: December 2, 2019
    Publication date: March 26, 2020
    Applicant: BASF SE
    Inventors: Christian Degering, Thorsten Eggert, Stefan Evers, Karl-Heinz Maure, Johannes Bongaerts
  • Patent number: 10494622
    Abstract: The aim of the invention is to improve the secretion of a protein from a host cell in order to increase the product yield of protein in a fermentation process. This is achieved by an expression vector comprising a) a promoter sequence and b) a nucleic acid sequence that codes for a protein. The protein comprises a signal peptide and an additional amino acid sequence, and the signal peptide comprises an amino acid sequence that is at least 80% identical to the amino acid sequence specified in SEQ ID NO: 2, at least 80% identical to the amino acid sequence specified in SEQ ID NO: 4, at least 80% identical to the amino acid sequence specified in SEQ ID NO: 6, or the signal peptide comprises an amino acid sequence that is structurally homologous to at least one of said sequences.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: December 3, 2019
    Assignee: BASF SE
    Inventors: Christian Degering, Thorsten Eggert, Stefan Evers, Karl-Heinz Maurer, Johannes Bongaerts
  • Publication number: 20190224102
    Abstract: The invention relates to an antiperspirant cosmetic agent which includes at least one specific chitosan and which is free of aluminum-containing compounds, in particular free of halides and/or hydroxy halides of aluminum and/or zirconium. The present invention further relates to the use of a specific chitosan and to a non-therapeutic method for reducing body perspiration. Adding or using the at least one specific chitosan ensures that the sweat gland(s) is/are effectively influenced, thus resulting in a significant reduction in underarm perspiration even in the absence of antiperspirant aluminum-containing compounds.
    Type: Application
    Filed: April 2, 2019
    Publication date: July 25, 2019
    Applicant: Henkel AG & Co. KGaA
    Inventors: Bernhard Banowski, Stefan Evers, Marcus Claas
  • Patent number: 10123958
    Abstract: The present invention relates to an antiperspirant cosmetic agent including at least one specific protein from legumes of the genus Pisum and/or Phaseolus and/or Vigna and/or Macrotyloma or from cruciferous plants of the genus Brassica and including no aluminum and/or zirconium halides and/or hydroxyhalides. The present invention further relates to the use of a specific protein and to a non-therapeutic method for reducing body perspiration. Adding or using said at least one specific protein ensures that the sweat gland(s) are effectively influenced, thus resulting in a significant reduction in axillary sweat even in the absence of antiperspirant aluminum salts.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: November 13, 2018
    Assignee: Henkel AG & Co. KGaA
    Inventors: Bernhard Banowski, Stefan Evers
  • Publication number: 20180073005
    Abstract: The aim of the invention is to improve the secretion of a protein from a host cell in order to increase the product yield of protein in a fermentation process. This is achieved by an expression vector comprising a) a promoter sequence and b) a nucleic acid sequence that codes for a protein. The protein comprises a signal peptide and an additional amino acid sequence, and the signal peptide comprises an amino acid sequence that is at least 80% identical to the amino acid sequence specified in SEQ ID NO 2, at least 80% identical to the amino acid sequence specified in SEQ ID NO 4, at least 80% identical to the amino acid sequence specified in SEQ ID NO 6, or the signal peptide comprises an amino acid sequence that is structurally homologous to at least one of said sequences.
    Type: Application
    Filed: September 22, 2017
    Publication date: March 15, 2018
    Applicant: BASF SE
    Inventors: Christian Degering, Thorsten Eggert, Stefan Evers, Karl-Heinz Maurer, Johannes Bongaerts
  • Patent number: 9803183
    Abstract: The aim of the invention is to improve the secretion of a protein from a host cell in order to increase the product yield of protein in a fermentation process. This is achieved by an expression vector comprising a promoter sequence and a nucleic acid sequence that codes for a protein. The protein comprises a signal peptide and an additional amino acid sequence, and the signal peptide comprises an amino acid sequence that is at least 80% identical to the amino acid sequence specified SEQ ID NO: 2, at least 80% identical to the amino acid sequence specified in SEQ ID NO: 4, at least 80% identical to the amino acid sequence specified in SEQ ID NO: 6, or the signal peptide comprises an amino acid sequence that is structurally homologous to at least one of said sequences.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: October 31, 2017
    Assignee: BASF SE
    Inventors: Christian Degering, Thorsten Eggert, Stefan Evers, Karl-Heinz Maurer, Johannes Bongaerts
  • Patent number: 9725704
    Abstract: In a microbial fermentation, the aim is to increase the product yield of protein. This is achieved by a method in which an expression construct is introduced into a microorganism of the species Bacillus pumilus which comprises a promoter and a nucleic acid coding for the protein, and the protein is expressed in said expression construct.
    Type: Grant
    Filed: January 29, 2013
    Date of Patent: August 8, 2017
    Assignee: BASF SE
    Inventors: Tobias Kueppers, Victoria Steffen, Renee Charlott Eichstadt, Stefan Evers, Karl-Heinz Maurer, Johannes Bongaerts, Hendrik Hellmuth, Thomas Weber, Timothy O'Connell
  • Publication number: 20170216182
    Abstract: The invention relates to an antiperspirant cosmetic agent which includes at least one specific chitosan and which is free of aluminum-containing compounds, in particular free of halides and/or hydroxy halides of aluminum and/or zirconium. The present invention further relates to the use of a specific chitosan and to a non-therapeutic method for reducing body perspiration. Adding or using the at least one specific chitosan ensures that the sweat gland(s) is/are effectively influenced, thus resulting in a significant reduction in underarm perspiration even in the absence of antiperspirant aluminum-containing compounds.
    Type: Application
    Filed: April 20, 2017
    Publication date: August 3, 2017
    Applicant: Henkel AG & Co. KGaA
    Inventors: Bernhard Banowski, Stefan Evers, Marcus Claas
  • Publication number: 20170209573
    Abstract: The present invention relates to methods of treating a disease, and methods for reduction of the formation of anti-drug antibodies (ADAs) in response to the administration of a therapeutic agent. The invention further relates to methods of treating a disease, particularly a B-cell proliferative disorder, and methods for reduction of adverse effects in response to the administration of a therapeutic agent, particularly a T-cell activating therapeutic agent.
    Type: Application
    Filed: December 7, 2016
    Publication date: July 27, 2017
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Marina Bacac, Stefan Evers, Christian Klein, Pavel Pisa, Eva Rossmann, Jose Saro, Pablo Umana
  • Patent number: 9695461
    Abstract: The stabilization of a hydrolytic enzyme in a liquid preparation is to be improved through a component that stabilizes the hydrolytic enzyme. This is accomplished by a method for adapting a hydrolytic enzyme to a component that stabilizes the hydrolytic enzyme, comprising the following method steps: a) providing a hydrolytic enzyme (starting enzyme) and a component that stabilizes the hydrolytic enzyme and that comprises a reversible inhibitor of the hydrolytic enzyme; b) changing the amino acid sequence of the hydrolytic enzyme in at least one position, by substitution, deletion or insertion; c) determining the relative activity of the hydrolytic enzyme from step b) and the relative activity of the starting enzyme in a liquid preparation; d) selecting the hydrolytic enzyme that has a reduced relative activity by comparison with the relative activity of the starting enzyme.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: July 4, 2017
    Assignee: Henkel AG & Co. KGaA
    Inventors: Petra Siegert, Stefan Evers, Marion Merkel, Nina Mussmann, Hendrik Hellmuth, Timothy O'Connell, Karl-Heinz Maurer, Ulrich Schwaneberg, Felix Jakob, Ronny Martinez, Brian Laufs, Ayhan Aydemir, Thomas Weber
  • Publication number: 20170157017
    Abstract: The invention relates to an antiperspirant cosmetic including at least one specific design protein and which is exempt of aluminum and/or zirconium halides and/or hydroxy halides. The invention further relates to the use of a specific protein and to a non-therapeutic method for reducing body perspiration. Adding or using said at least one specific protein ensures that the sweat gland(s) is/are effectively influenced, thus resulting in a significant reduction in axillary hyperhidrosis even in the absence of antiperspirant aluminum salts.
    Type: Application
    Filed: February 16, 2017
    Publication date: June 8, 2017
    Applicant: Henkel AG & Co. KGaA
    Inventors: Bernhard Banowski, Stefan Evers, Timothy O'Connell
  • Publication number: 20170151150
    Abstract: The invention relates to an antiperspirant cosmetic including at least one specific protein from human or animal sources or from fish or birds or eggs and which is exempt of aluminum and/or zirconium halides and/or hydroxy halides and Bovine serum albumin (BSA). The invention further relates to the use of a specific protein and to a non-therapeutic method for reducing body perspiration. Adding or using said at least one specific protein ensures that the sweat gland(s) is/are effectively influenced, thus resulting in a significant reduction in axillary hyperhidrosis even in the absence of antiperspirant aluminum salts.
    Type: Application
    Filed: February 10, 2017
    Publication date: June 1, 2017
    Applicant: Henkel AG & Co. KGaA
    Inventors: Bernhard Banowski, Stefan Evers
  • Publication number: 20170151151
    Abstract: The present invention relates to an antiperspirant cosmetic agent that includes at least one specific protein from Malvaceae of the genus Adansonia and is free of aluminum and/or zirconium halides and/or hydroxy halides. The present invention further relates to the use of a specific protein and to a non-therapeutic method for reducing body perspiration. Adding or using said at least one specific protein ensures that the sweat gland(s) is/are effectively influenced, thus resulting in a significant reduction in underarm sweat even in the absence of antiperspirant aluminum salts.
    Type: Application
    Filed: February 10, 2017
    Publication date: June 1, 2017
    Applicant: Henkel AG & Co. KGaA
    Inventors: Bernhard Banowski, Stefan Evers
  • Patent number: 9663798
    Abstract: The aim is to increase the protein product yield in microbial fermentation. This is achieved by a method which introduces into a microorganism not only a first expression construct which encodes the protein, but also a second expression construct which encodes an auxiliary protease which differs from the protein, is proteolytically active and which comprises an amino acid sequence which is at least 50% identical to the amino acid sequence indicated in SEQ ID NO. 1.
    Type: Grant
    Filed: April 5, 2012
    Date of Patent: May 30, 2017
    Assignee: BASF SE
    Inventors: Lukas Maksym, Ramona Knab, Stefan Evers, Karl-Heinz Maurer, Johannes Bongaerts
  • Publication number: 20170112750
    Abstract: The invention relates to an antiperspirant cosmetic including at least one specific protein from poaceae of the genus triticum and/or oryza and including no aluminum and/or zirconium halides and/or hydroxy halides. The invention further relates to the use of a specific protein and to a non-therapeutic method for reducing body perspiration. Adding or using said at least one specific protein ensures that the sweat gland(s) is/are effectively influenced, thus resulting in a significant reduction in axillary hyperhidrosis even in the absence of antiperspirant aluminum salts.
    Type: Application
    Filed: January 5, 2017
    Publication date: April 27, 2017
    Applicant: Henkel AG & Co. KGaA
    Inventors: Bernhard Banowski, Stefan Evers