Abstract: It relates to a pharmaceutical combination comprising a KRAS G12C inhibitor, in particular 1-{6-[(4M)-4-(5-Chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro [3.3] heptan-2-yl} prop-2-en-1-one (Compound A) and one or more therapeutically active agents selected from a SHP2 inhibitor (e.g. TNO155) and a PD-1 inhibitor, pharmaceutical compositions comprising the same; and methods of using such combinations and compositions in the treatment or prevention of a cancer or a tumor, in particular wherein the cancer or tumor is KRAS G12C mutated.

Abstract: The invention concerns a composite material consisting of intermetallic phases and ceramic, in particular in the form of a coating on metallic substrates, as well as an arc wire spraying process for production of the composite material in which the intermetallic phases and the ceramics to be deposited are newly formed during the deposit process from the components of the supplied wires by chemical reaction. The invention further concerns wear resistant layers formed by the composites, tribologic layers and plating or hard-facing materials.

Abstract: The present invention relates to a process for applying a wear-resistant tribological coating to a sliding region of a synchronizer ring in which a thermally sprayed coating contains a maximum of approximately 40% by weight of solid lubricant, as well as to a synchronizer ring sliding region having a coating applied by such a process.

Abstract: A cylinder head for internal combustion engines, comprising a metallic valve seat ring that is formed by a thermally sprayed homogeneous layer made of a basic Co or Co/Mo alloy. The sum of the Co content and Mo content in the alloy exceeds 50 percent by weight while the Fe content lies below 5 percent by weight. Also disclosed is a method for thermally spraying said valve seat ring by means of an arc wire spraying process with the aid of at least two filler wires and/or composite wires, the essential Co portion in the deposited layer being delivered by the jacket of the filler wire and/or the matrix of the composite wire.

Abstract: A cylinder head for internal combustion engines, comprising a metallic valve seat ring that is formed by a thermally sprayed homogeneous layer made of a basic Co or Co/Mo alloy. The sum of the Co content and Mo content in the alloy exceeds 50 percent by weight while the Fe content lies below 5 percent by weight. Also disclosed is a method for thermally spraying said valve seat ring by means of an arc wire spraying process with the aid of at least two filler wires and/or composite wires, the essential Co portion in the deposited layer being delivered by the jacket of the filler wire and/or the matrix of the composite wire.

Abstract: The invention concerns a composite material consisting of intermetallic phases and ceramic, in particular in the form of a coating on metallic substrates, as well as an arc wire spraying process for production of the composite material in which the intermetallic phases and the ceramics to be deposited are newly formed during the deposit process from the components of the supplied wires by chemical reaction. The invention further concerns wear resistant layers formed by the composites, tribologic layers and plating or hard-facing materials.

Abstract: The present invention relates to a synchronizer ring having an annular body which has a sliding region, the sliding region being provided with a wear-resistant tribological coating. According to the invention, it is provided for the tribological coating to be a thermally sprayed coating which contains a maximum of approximately 40% by weight of solid lubricant.