Abstract: The present invention relates to a method for determining an organ function in a subject, comprising the steps of: providing a first concentration-time curve obtained by transcutaneously measuring in a body fluid at a first position background fluorescence in at least one first time point and fluorescence of an indicator compound in at least a second, a third, a fourth, a fifth, and a sixth time point; providing a second concentration curve obtained by transcutaneously measuring in a body fluid at a second position background fluorescence in at least one seventh time point and fluorescence of an indicator compound in at least a eighth, a ninth, a tenth, an eleventh, and a twelfth time point; fitting the first and the second concentration curve into a kinetic model representing at least four diffusion compartments; and thereby determining an organ function in a subject.

Abstract: A method for aligning a workpiece in a working space of a machine tool having a numerical control system uses a probe. 3D models of the working space, probe, and workpiece are virtually displayed. The workpiece is positioned in the working space and the virtual workpiece is positioned in the virtual working space so that there is an initial coincidence between positions thereof. The probe is manually positioned relative to the workpiece, wherein a planned probing point and probing direction are selected based on a minimum distance of the virtual probe from the virtual workpiece, and are displayed. Enabling of the probing is based on quality of the planned probing point, and, when enabled, a probing operation is triggered, and coordinates of a probing point are determined. The position of the workpiece is recalculated using these coordinates, and the position of the virtual workpiece is updated.

Abstract: A hand-held observation device includes: a laser rangefinder (LRF) unit configured to measure a distance between the observation device and a target point on a remote target, a camera configured to capture images of the target, a pose detection unit configured to detect a pose of the observation device, a display unit configured to display an image of the target, a user input device and a digital processing unit comprising a memory for storing program data and measurement data.

Abstract: Various embodiments provide a direct current (DC)-DC converter circuit. The DC-DC converter circuit includes a control circuit to switch the DC-DC converter circuit between a charge state, a discharge state, and a tri-state mode. As part of a first control loop, the control circuit may switch the DC-DC converter between the charge state and the discharge state based on the output voltage to provide the output voltage with the target voltage level. Additionally, as part of a second control loop, the control circuit may switch the DC-DC converter between the charge state and the discharge state based on the current through an inductor of the DC-DC converter. The second control loop may provide overcurrent protection for the DC-DC converter. Other embodiments may be described and claimed.

Abstract: The present invention relates to a method for identifying inhibitors of breast cancer metastasis based on a screening with proteins that are specific for the secretome of a chondrocyte, preferably cytokines and/or chemokines. The ligands as identified lead to a decrease of the migration and/or a re-differentiation of a breast cancer cell and/or a reduction of the number and/or size of breast cancer metastases. The present invention further relates to a method for detecting breast cancer metastasis, comprising the step of detecting at least one protein that is specific for the secretome of a chondrocyte, and for methods for treating and/or preventing breast cancer metastasis in a patient in need thereof, comprising the step of administering an effective amount of at least one ligand for one protein that is specific for the secretome of a chondrocyte to said patient in need thereof.

Abstract: The present invention relates to a method for identifying inhibitors of breast cancer metastasis based on a screening with proteins that are specific for the secretome of a chondrocyte, preferably cytokines and/or chemokines. The ligands as identified lead to a decrease of the migration and/or a re-differentiation of a breast cancer cell and/or a reduction of the number and/or size of breast cancer metastases. The present invention further relates to a method for detecting breast cancer metastasis, comprising the step of detecting at least one protein that is specific for the secretome of a chondrocyte, and for methods for treating and/or preventing breast cancer metastasis in a patient in need thereof, comprising the step of administering an effective amount of at least one ligand for one protein that is specific for the secretome of a chondrocyte to said patient in need thereof.

Abstract: A compound of formula (1), (1?), (1?) or (1??) or a pharmaceutically acceptable salt thereof, for use in the treatment of diseases or conditions for which a bromodomain inhibitor is indicated.

Abstract: Various embodiments provide a direct current (DC)-DC converter circuit. The DC-DC converter circuit includes a control circuit to switch the DC-DC converter circuit between a charge state, a discharge state, and a tri-state mode. As part of a first control loop, the control circuit may switch the DC-DC converter between the charge state and the discharge state based on the output voltage to provide the output voltage with the target voltage level. Additionally, as part of a second control loop, the control circuit may switch the DC-DC converter between the charge state and the discharge state based on the current through an inductor of the DC-DC converter. The second control loop may provide overcurrent protection for the DC-DC converter. Other embodiments may be described and claimed.

Abstract: A flash memory arrangement includes first memory cells for non-volatile memory of information and a read-write circuit. The read-write circuit includes a write latch, read amplifier, bit circuit pre-charge circuit, and databus interface, with the first memory cell being connected to a first bit circuit, word circuit, VSE circuit, and a select circuit, and the read-write circuit being connected to a column decoder, databus, and a read control signal circuit. A first memory column is arranged such that in a first partial matrix the first memory cell is arranged, in which a first select transistor, a memory transistor, and a second select transistor are arranged between the first bit circuit and a discharge hub. The second select transistor can be controlled by a global, non address-decoded read-write select circuit. At every bit circuit, a reference memory cell is arranged. A second partial matrix is provided equivalent to the first partial matrix.

Abstract: A flash memory arrangement includes first memory cells for non-volatile memory of information and a read-write circuit. The read-write circuit includes a write latch, read amplifier, bit circuit pre-charge circuit, and databus interface, with the first memory cell being connected to a first bit circuit, word circuit, VSE circuit, and a select circuit, and the read-write circuit being connected to a column decoder, databus, and a read control signal circuit. A first memory column is arranged such that in a first partial matrix the first memory cell is arranged, in which a first select transistor, a memory transistor, and a second select transistor are arranged between the first bit circuit and a discharge hub. The second select transistor can be controlled by a global, non address-decoded read-write select circuit. At every bit circuit, a reference memory cell is arranged. A second partial matrix is provided equivalent to the first partial matrix.

Abstract: A compound of formula (1), (1?), (1?) or (1??) or a pharmaceutically acceptable salt thereof, for use in the treatment of diseases or conditions for which a bromodomain inhibitor is indicated.

Abstract: The present invention relates to a method for identifying inhibitors of breast cancer metastasis based on a screening with proteins that are specific for the secretome of a chondrocyte, preferably cytokines and/or chemokines. The ligands as identified lead to a decrease of the migration and/or a re-differentiation of a breast cancer cell and/or a reduction of the number and/or size of breast cancer metastases. The present invention further relates to a method for detecting breast cancer metastasis, comprising the step of detecting at least one protein that is specific for the secretome of a chondrocyte, and for methods for treating and/or preventing breast cancer metastasis in a patient in need thereof, comprising the step of administering an effective amount of at least one ligand for one protein that is specific for the secretome of a chondrocyte to said patient in need thereof.

Abstract: In a vehicle part with a structural reinforcement part, the structural reinforcement part comprises fibers embedded in plastic material to absorb tensile and/or compressive forces or tensile (FZ) and/or compressive stresses.

Abstract: The invention relates to a sensor system including a plurality of sensor elements which are designed so that the elements detect at least partially different primary measured values and utilize at least partially different measurement principles, further including a signal processing apparatus, an interface apparatus and a plurality of functional apparatuses. The sensor elements are connected to the signal processing apparatus, which is designed so that it includes at least one of the following signal processing functions each for at least one of the sensor elements and/or the output signals thereof, an error handling, a filtering, a calculation and/or provision of a derived measured value. At least one measured value is derived from at least one primary measured value of one or more sensor elements, and all functional apparatuses are connected to the signal processing apparatus via the interface apparatus and the signal processing apparatus provides the signal processing functions.

Abstract: Oscillator and electronic device comprising an oscillator, wherein the oscillator has an RC-circuit and a push-pull stage. A tapping point of the RC-circuit is coupled to an input of the push-pull stage and an output of the push-pull stage is fed back to a switching transistor which is coupled to the tapping point of the RC-circuit.

Abstract: A memory circuit includes a high voltage region providing storage of a nonvolatile bit, and a low voltage region providing at least partial storage of a volatile bit. The high and low voltage regions are isolated from one another and formed by a plurality of transistors in series between a current source and a bit line.

Abstract: The invention relates to a method for the production of both MOS transistors with extremely low leakage currents at the pn junctions and logic/switching transistors, whose gates are laterally defined by spacers in a p-substrate or a p-well in an n-substrate. The aim of the invention is to provide a method for the production of MOS transistors with extremely low leakage currents that allows for parallel logic/switching transistors.

Abstract: A micromechanical rotation rate sensor has at least one first and one second seismic mass coupled to at least one first drive device and are suspended such that the first and second seismic masses are driven such that they are deflected in antiphase in one drive mode, with the rotation rate sensor being designed such that it can detect rotation rates about at least two mutually essentially orthogonal sensitive axes, wherein at least the first and second seismic masses are designed and suspended such that they oscillate in antiphase in a first read mode when a first rotation rate about the first sensitive axis is detected, and the first and second seismic masses and/or additional seismic masses are designed and suspended such that they oscillate in antiphase in a second read mode when a second rotation rate about the second sensitive axis is detected.

Abstract: A memory circuit includes a high voltage region providing storage of a nonvolatile bit, and a low voltage region providing at least partial storage of a volatile bit. The high and low voltage regions are isolated from one another and formed by a plurality of transistors in series between a current source and a bit line.

Abstract: Systems and methods use cyclical propellers with dynamic blade angle control to extract power from waves. A control system for such implementations can adapt pitching schedules for the blades of the cyclical propellers for efficient energy extraction and/or to control reactive forces. The cyclical propellers may be installed on the floor of a body of water or other liquid, on a submarine, or on a surface float, and blades may extend vertically or horizontally depending on the character of the waves. Several cyclical propellers can be combined into a single unit operated to minimize net reactive force or torque, to propel the unit horizontally or vertically, and/or to stabilize the unit. Such units can be installed with minimal or no moorings.